2006
DOI: 10.1007/s00439-006-0190-5
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Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia

Abstract: A number of studies have suggested an association between schizophrenia and the tryptophan hydroxylase (TPH) and tyrosine hydroxylase (TH) genes. On the other hand, several studies attempting to replicate these findings have produced mixed results, possibly reflecting inadequate statistical power of the individual studies as well as the heterogeneity inherent in schizophrenia. In an attempt to clarify this inconsistency our meta-analysis has combined all the studies using multiple research methods published up… Show more

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Cited by 31 publications
(18 citation statements)
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“…In accordance with the findings of Li & He (2006), the polymorphism of the A779C gene, briefly called TPH1 (see above for the details), was one of two polymorphisms associated with schizophrenia. These findings immediately created a link with the discussion on the madness-creativity affinity on the grounds of a partly common genetic basis; however, more evidence pointed to affective disorders rather than schizophrenia or similar disorders as being implicated.…”
Section: Molecular Genetics Contributes To Creativity -Mood Disorderssupporting
confidence: 65%
“…In accordance with the findings of Li & He (2006), the polymorphism of the A779C gene, briefly called TPH1 (see above for the details), was one of two polymorphisms associated with schizophrenia. These findings immediately created a link with the discussion on the madness-creativity affinity on the grounds of a partly common genetic basis; however, more evidence pointed to affective disorders rather than schizophrenia or similar disorders as being implicated.…”
Section: Molecular Genetics Contributes To Creativity -Mood Disorderssupporting
confidence: 65%
“…A meta-analysis showed a significant association between TPH1 218A/C and schizophrenia (Li and He, 2006b). The newly updated schizophrenia gene meta-analysis revealed that TPH1 is one of the four genes positively associated with schizophrenia, showing strong epidemiological credibility (Allen et al, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…Nevertheless, association studies and even recent meta-analytic evidence have produced conflicting results (Li and He 2006;Abdolmaleky et al 2004;Fan and Sklar 2005). HTR2A is widely distributed in the brain, with highest concentrations in the cortex (Hoyer et al 1986), and is localized on cortical and hippocampal pyramidal glutamatergic neurons (Jakab and GoldmanRakic 1998), as well as on g-aminobutyric acid (GABA)ergic interneurons (Willins et al 1997), both of which play a key role in schizophrenia.…”
Section: Introductionmentioning
confidence: 98%
“…Genetic variation of TPH1 gene has been associated with the risk of schizophrenia in previous reports (Zaboli et al 2006;Anttila et al 2007). Metaanalysis study showed a significant association between 218A/C and schizophrenia (Li and He 2006). In contrast to TPH1, TPH2 is expressed in the raphe nucleus and directly affects the serotonergic pathways of the brain (Patel et al 2004).…”
Section: Introductionmentioning
confidence: 98%