Abstract. In the event of natural disasters, relief distribution is the most challenging problem in emergency transportation. What is important in response to disaster is victims' relief in disaster areas with the quick distribution of vital commodity. In this regard, damage to infrastructure (e.g., roads) can make trouble in designing a distribution network. Therefore, this paper considers a problem using a three-stage approach. In the rst stage, pre-processing of model inputs is done through an Arti cial Neural Fuzzy Inference System (ANFIS) followed by investigating the safest route for each cluster using decision-making techniques and graph theory. In the second stage, a heterogeneous multi-depot multimode vehicle routing problem is formulated for minimizing the transportation time and maximizing the reliability. Finally, since the routing problem is NP-hard, 2 multi-objective meta-heuristic algorithms, namely, Non-dominated Sorting Genetic Algorithm (NSGA-II) and Multi-Objective Fire y Algorithm (MOFA), are proposed to obtain the optimal solution and their performances are compared through a set of randomly generated test problems. The results show that for this routing problem, the MOFF gives better solutions than NSGA-II does, and it performs well in terms of accuracy and solution time.