2018
DOI: 10.3390/ijerph15020326
|View full text |Cite
|
Sign up to set email alerts
|

Meta-Prediction of MTHFR Gene Polymorphisms and Air Pollution on the Risk of Hypertensive Disorders in Pregnancy Worldwide

Abstract: Hypertensive disorders in pregnancy (HDP) are devastating health hazards for both women and children. Both methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and air pollution can affect health status and result in increased risk of HDP for women. The major objective of this study was to investigate the effect of MTHFR polymorphisms, air pollution, and their interaction on the risk of HDP by using meta-predictive analytics. We searched various databases comprehensively to access all available studi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

6
17
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 19 publications
(23 citation statements)
references
References 56 publications
(89 reference statements)
6
17
0
Order By: Relevance
“…In agreement with our study, no significant relationship of F5:c.1601G > A with preeclampsia was found in Turkish and Iranian patients [32,33]. This finding strengthens the hypothesis that F5 gene variations may have a role in The results of the present study exhibited the increased risk of preeclampsia with CT genotype under the overdominant model, and with the T allele of MTHFR: c.665C > T. In a meta-analysis, Yang et al [34] included 57 different studies that showed TT as a risk factor for preeclampsia in Caucasians, South Americans, East Asians and Africans whereas, TT + CT was observed as a risk factor in East Asians. In the same study, a protective role was observed with CC, CT, and CC + CT in East Asians and CT in South Asians; however, no significant association was found in Hispanics and Middle East population.…”
Section: Discussionsupporting
confidence: 92%
“…In agreement with our study, no significant relationship of F5:c.1601G > A with preeclampsia was found in Turkish and Iranian patients [32,33]. This finding strengthens the hypothesis that F5 gene variations may have a role in The results of the present study exhibited the increased risk of preeclampsia with CT genotype under the overdominant model, and with the T allele of MTHFR: c.665C > T. In a meta-analysis, Yang et al [34] included 57 different studies that showed TT as a risk factor for preeclampsia in Caucasians, South Americans, East Asians and Africans whereas, TT + CT was observed as a risk factor in East Asians. In the same study, a protective role was observed with CC, CT, and CC + CT in East Asians and CT in South Asians; however, no significant association was found in Hispanics and Middle East population.…”
Section: Discussionsupporting
confidence: 92%
“…While our findings were not significant, this trend is consistent with the emerging pattern of association of air pollution with gene polymorphisms and disease risk [ 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. Previous studies have found significantly increased polymorphisms of the MTHFR gene with increased air pollution levels in various conditions including colorectal cancer, breast cancer, leukemia, Alzheimer’s disease, and hypertensive disorders during pregnancy (HDP) [ 30 , 31 , 33 , 34 , 35 ], and increased disease risk for HDP [ 35 ]. Although the MTHFR gene is known to be heat sensitive [ 84 , 85 ], there is no current evidence of heat sensitivity related to the NOS3 mechanism; however, the trend of increased NOS3 polymorphisms with increased air pollution for countries with higher risk (RR > 2) is consistent with each of these previous studies [ 30 , 31 , 33 , 34 , 35 ].…”
Section: Discussionsupporting
confidence: 90%
“…Pooled risk ratios (RR) for NOS3 894 genotypes for cases and controls and 95% confidence intervals (CI) were calculated for the associations of polymorphisms and IHD with heterogeneity tested before selection of an association model. Pooled RRs are preferred to odds ratios (OR) according to related consensus reports for the field of study [ 30 , 59 , 60 ]; they have been demonstrated to be more robust and better for comparison due to standardization of the denominator as opposed to using only one genotype as the denominator [ 30 , 31 , 32 , 33 , 34 , 35 , 59 , 60 , 61 , 62 , 63 ]. We used total counts of all three NOS3 894 genotypes (homozygous TT, heterozygous GT, and wild-type GG genotypes) as the denominators to compute standardized ratios for RRs.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Moreover, methylation of placental DNA, ADORA2, has been associated with maternal exposure to NO 2 during the second trimester and the development of PE [50]. Furthermore, a recent meta-analysis has predicted a genetic predisposition to reduced DNA methylation in preeclampsia associated with air pollution exposure: methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphisms [51]. This process may, therefore, also trigger the first stage of the two-stage model [52][53][54].…”
Section: Discussionmentioning
confidence: 99%