Meta-stable state photoacid containing β-estradiol fragment with photomodulated biological activity and anti-cancer stem cells properties

Ozhogin, Ilya V.; Zolotukhin, Peter V.; Makarova, Nadezhda I.; Rostovtseva, Irina A.; Pugachev, Artem D.; Kozlenko, Anastasia S.; Belanova, Anna A.; Borodkin, Gennady S.; Dorogan, Igor V.; Metelitsa, Anatoly V.

doi:10.1016/j.jphotobiol.2024.112964

Journal of Photochemistry and Photobiology B: Biology

2024

DOI: 10.1016/j.jphotobiol.2024.112964

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Meta-stable state photoacid containing β-estradiol fragment with photomodulated biological activity and anti-cancer stem cells properties

Ilya V. Ozhogin,

Peter V. Zolotukhin,

Nadezhda I. Makarova

et al.

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2024

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Cited by 3 publications

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Visible‐ and Near‐Infrared Light‐Driven Molecular Photoswitches for Biological Applications

Xu,

Tang,

2024

Adv Funct Materials

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Molecular photoswitches can undergo isomerization under light exposure, making them uniquely attractive for high spatiotemporal resolution remote control of biological functions. Visible and near‐infrared (NIR) light, with their low energy consumption, high safety, and strong tissue penetration, are particularly suitable for biological applications. Therefore, developing visible‐ and NIR light‐driven molecular photoswitches for biological use is of great significance. This review introduces the most common visible‐ and NIR light‐driven molecular photoswitches and presents the state‐of‐art of their applications in bioimaging, biosensing, drug delivery, photocontrolled cancer phototherapy, and photopharmacology. The opportunities and challenges of the photoswitches for their future development in biological applications are outlined.

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Visible‐ and Near‐Infrared Light‐Driven Molecular Photoswitches for Biological Applications

Xu,

Tang,

2024

Adv Funct Materials

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Anion and Substituents Effect on Spectral‐Kinetic and Biological Characteristics of Spiropyran Salts

Pugachev,

Kozlenko,

Sazykina

et al. 2024

ChemBioChem

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Spiropyran salts containing a cationic vinyl‐3H‐indolium moiety are characterized by NIR absorption and fluorescence of their merocyanine forms. This feature makes them promising fluorescent probes and markers for bioimaging. The article focuses on the synthesis and study of the spectral, kinetic and toxic characteristics of such compounds with respect to various substituents in different moieties and the type of anion. A detailed analysis of the acquired data made it possible to draw some important conclusions regarding the influence of structural factors, which will be very useful for the further rational design of such derivatives. In particular, it was shown that the counterion has minimal effect on the spectral and kinetic characteristics of the dyes but dramatically affects the toxicity of the compounds. Following selection of the most appropriate compounds, bioimaging experiments were carried out to visualize planktonic bacteria and bacterial biofilms of E. coli and A. calcoaceticus. The ability to visualize biofilms is critical for the diagnosis of chronic diseases. By the results of molecular docking a theoretical interaction pattern between spiropyran molecules and DNA was proposed.

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Recent Progress in Regulating the Activity of Enzymes with Photoswitchable Inhibitors

Chen

2024

Molecules

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Photoregulation of biomolecules has become crucial tools in chemical biology, because light enables access under mild conditions and with delicate spatiotemporal control. The control of enzyme activity in a reversible way is a challenge. To achieve it, a facile approach is to use photoswitchable inhibitors. This review highlights recent progress in photoswitchable inhibitors based on azobenzenes units. The progress suggests that the incorporation of an azobenzene unit to a known inhibitor is an effective method for preparing a photoswitchable inhibitor, and with these photoswitchable inhibitors, the activity of enzymes can be regulated by optical control, which is valuable in both basic science and therapeutic applications.

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Meta-stable state photoacid containing β-estradiol fragment with photomodulated biological activity and anti-cancer stem cells properties

Cited by 3 publications

References 45 publications

Visible‐ and Near‐Infrared Light‐Driven Molecular Photoswitches for Biological Applications

Visible‐ and Near‐Infrared Light‐Driven Molecular Photoswitches for Biological Applications

Anion and Substituents Effect on Spectral‐Kinetic and Biological Characteristics of Spiropyran Salts

Recent Progress in Regulating the Activity of Enzymes with Photoswitchable Inhibitors

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