Metabiotics: One Step ahead of Probiotics; an Insight into Mechanisms Involved in Anticancerous Effect in Colorectal Cancer

Sharma, Megha; Shukla, Geeta

doi:10.3389/fmicb.2016.01940

Cited by 121 publications

(73 citation statements)

References 179 publications

(162 reference statements)

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“…In addition to that, studies have also reported that small interfering RNAs has been utilized for inhibition of HIV, influenza infection and hepatitis [88]. In continuation with this, certain amino acid derivatives including selenocysteines and selenomethionines, have been reported to be synthesized in yeasts and Lactobacilli [89]. They have been found to play protective role against cancer, counteract oxidative stress and activate anabolic pathways of thyroid hormone biosynthesis and modulate immune system.…”

Section: Miscellaneousmentioning

confidence: 90%

Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules

Singh¹,

Vishwakarma²,

Singhal³

2018

ABB

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The intricate "orchestered molecular conversation" between the host and gut microbiome is one of the most dynamic research areas in recent years. The rhythmic chemical cross talk in the form of bioactive metabolites and signalling molecules synthesized by gut microbiome plays a significant role for the modulation of human health in diversified ways. They are recognized as low molecular weight (LMW) molecules having versatile chemical attributes. They possess magnificent capability of interacting with surrounding environment and controlling the genes for various genetic, biochemical and physiological functions for maintaining the homeostasis that is now-a-days termed as "small molecules microbes originated (SMOM) homeostasis" in the host. These metabolic signatures have close structural and functional resemblance with small molecules synthesized by host eukaryotic cells and dietary components. Therefore, they may be considered as universalized metabolites contributing to the remarkable phenomenon of epigenetic regulation, cell to cell communication and stability of genome manifesting the overall growth and development of the host and known as "metabiotics". The wide panorama of utilization of probiotics is continuously expanding and conferring the major health benefits through metabiotic components are gaining tremendous momentum therefore recognized as "hidden soldiers" of the body. Therefore firstly, we outline the need and types of metabiotic molecules and depicting their role in human health. Then, we summarize their preventive and therapeutic avenues in various diseases and finally, we propose the current technological interventions, bottlenecks and future perspectives in this field that are implied for accelerating their comprehensive understanding and utilization at industrial scale.

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Section: Miscellaneousmentioning

confidence: 90%

Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules

Singh¹,

Vishwakarma²,

Singhal³

2018

ABB

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“…Probiotics not only produce anti-inflammatory factors to extend the immune stimulating function, but also secrete antioxidant, anti-cancer compounds, short chain fatty acids to improve intestinal barrier function [51,52]. Cyclooxygenase-2 can promote tumor angiogenesis, while probiotics inhibit carcinogenesis by reducing cyclooxygenase-2's expression [53].…”

Section: Probiotics In the Inhibition Of Crcmentioning

confidence: 99%

Role of Gut Microbiota in the Development and Treatment of Colorectal Cancer

et al. 2018

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Human guts harbor abundant microbes that regulate many aspects of host physiology. However, bacterial imbalance or dysbiosis in the gut due to the dietary or environmental changes may cause colorectal cancer (CRC). Increasing studies show that gut microbiota plays an important role in the occurrence and development of CRC, as a result of virulence factors, bacterial metabolites, or inflammatory pathways. In the future, probiotics or targeting the microbiota will probably be a powerful weapon in the battle against CRC. This review seeks to outline the relationship between gut microbiota and the development of CRC as well as the potential mechanisms of microbiota involved in treatment of CRC, so as to provide some references for research on the development, prevention, and treatment of this disease.

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“…This finding suggests that the addition of specific probiotic bacteria to lactic acid products can provide patients with both good postoperative nutrition and some therapeutic benefits. Microbes have also been shown to exert apoptosis via multiple mechanisms in HT29 and HCT116 cell lines; exerting cytotoxic effects on cancer cells, secreting specific cytotoxic metabolites, and positively regulating the C-fos gene [60]. Second, probiotics can enhance the function of the intestinal epithelial barrier.…”

Section: A New Weapon Against Cancer: the Emergence Of Micro-ecologicmentioning

confidence: 99%

A Tool for the Treatment of Gastrointestinal Tumors: Micro-Ecological Immunotherapy

Dai¹,

Wu²,

Zhang³

et al. 2019

Journal of Nutritional Oncology

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It has been proposed that the intestinal microbiota and gastrointestinal tumors are interdependent. Changes in the microbiota can cause dysfunction of the gastrointestinal tract, thereby promoting carcinogenic changes, leading to the occurrence of gastrointestinal tumors. Recent studies on intestinal microbiota have opened up a new area in intestinal micro-ecological immunotherapy. The intestinal microbiota is a double-edged sword. Gut microbes participate in carcinogenesis, but can also be used for immunotherapy. The intestinal microbiota is also regulated by the daily diet. Intestinal micro-ecological immunotherapy combines intestinal immune nutrition and intestinal ecological nutrition to make full use of the intestinal microbiota to strengthen nutritional support. Micro-ecological immunotherapy enhances the body’s immune function by providing energy, improving the functional state of tissues and organs, protecting the intestinal mucosal barrier and maintaining normal intestinal microbiota balance. This involves, to some extent, PD-1 and PD-L1. The microbiota is beneficial to improve the clinical efficacy of conventional anti-cancer therapy and to reduce the incidence of complications. At the same time, micro-ecological immunotherapy is itself active and effective in the perioperative treatment of tumors, which is of great significance for the prognosis of the patient. Gastrointestinal tumors are increasingly linked to intestinal microbiota, and various microbiota-related technologies and drugs have been developed. In the future, the intestinal microbiota may represent a screening marker for gastrointestinal tumors. In addition, clinicians may be able to prevent and treat cancers by changing the gene expression levels of certain microbiota, or by regulating the types of microbes present.

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Metabiotics: One Step ahead of Probiotics; an Insight into Mechanisms Involved in Anticancerous Effect in Colorectal Cancer

Cited by 121 publications

References 179 publications

Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules

Metabiotics: The Functional Metabolic Signatures of Probiotics: Current State-of-Art and Future Research Priorities—Metabiotics: Probiotics Effector Molecules

Role of Gut Microbiota in the Development and Treatment of Colorectal Cancer

A Tool for the Treatment of Gastrointestinal Tumors: Micro-Ecological Immunotherapy

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