Metabolic abnormalities associated with phosphoric acid ingestion

Caravati, E. Martin

doi:10.1016/s0196-0644(87)80532-2

Cited by 10 publications

(5 citation statements)

References 16 publications

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“…Increase serum phosphate concentration also inhibit bone resorption with reduced calcium release hydrogen ion loads produce a metabolic acidosis which further exacerbate hypocalcaemia (Frisch and Wyshak, 1994;Calvo, 2013). (Caravate, 2007). AST concentration showed significant (p< 0.05) elevation in treated group ( 97 ± 14.3 IU/L) in day 66 compared with control group (60.5± 9.7 IU/L).…”

Section: Resultsmentioning

confidence: 99%

The effect of some food additive on the liver function in laboratory animal

2018

Int. J. Biosci.

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Phosphorus is an essential element as it represents the second most abundant mineral in the human body.Therefore, this study was designed to investigate the effect of phosphoric acid additive in water on some hematological and biochemical parameters in rabbits. Twelve female adult rabbits were divided randomly into two groups equally. The first group received 10% of phosphoric acid in water while the second group was received tap water as control group. The blood was collected in zero day and in 66 day. The result revealed that the Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP) and inorganic phosphorus were significantly increased (P <0.05) in serum of treated group as compared with control group, while the total calcium concentration was significantly decreased (P <0.05) in serum of treated group in comparison with control group. On the other hand the results of the hematological parameters showed a significant decreasing (P <0.05) in the RBC count, Hb and PCV of the treated group, whereas the WBC count was significantly (P<0.05) increased in the treated group. In conclusion, the phosphoric acid additive in water caused several changes in some biochemical and hematological parameters in rabbits.

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Section: Resultsmentioning

confidence: 99%

The effect of some food additive on the liver function in laboratory animal

2018

Int. J. Biosci.

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“…Caravati (1987) reports a similar case of phosphoric acid ingestion with the patient successfully treated with an oral phosphate binder, aluminum hydroxide. Although the patient's phosphate level was 7.1 mmol/L, which was significantly lower than our patient's and the patient did not have significant caustic injuries [2]. Song, et al (2021) reports a patient with underlying chronic kidney disease stage 5 presenting with acute hyperphosphatemia (serum phosphate level of 6.23 mmol/l due to non-compliance to medications and dietary indiscretion.…”

Section: Ethical Disclosuresmentioning

confidence: 97%

“…Oral phosphate binders can be used to reduce further absorption. Dialysis can be considered, although one should be aware that IHD is significantly more efficient in phosphate removal than peritoneal dialysis [2]. Caravati (1987) reports a similar case of phosphoric acid ingestion with the patient successfully treated with an oral phosphate binder, aluminum hydroxide.…”

Section: Ethical Disclosuresmentioning

confidence: 99%

“…Dialysis can be considered, although one should be aware that IHD is significantly more efficient in phosphate removal than peritoneal dialysis [2]. Caravati (1987) reports a similar case of phosphoric acid ingestion with the patient successfully treated with an oral phosphate binder, aluminum hydroxide. Although the patient's phosphate level was 7.1 mmol/L, which was significantly lower than our patient's and the patient did not have significant caustic injuries [2].…”

Section: Ethical Disclosuresmentioning

confidence: 99%

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A Case of Severe Acute Hyperphosphatemia Secondary to Ingestion of Phosphoric Acid Solution Treated with Continuous Renal Replacement Therapy

Shan¹,

Baikunje²,

Chawla³

2022

Ann Nephrol

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“…Also, organs such as the liver and the pancreas are involved, eventually arriving at systemic multi‐organ failure . Moreover, renal failure leads to reabsorption of toxins and hypovolemia, and eventually respiratory impairment ensues leading to adult respiratory distress syndrome, disseminated intravascular coagulation, and death . During acidosis, there is migration of phosphorus from inside the cells to the extracellular fluid, increasing serum phosphate levels, leading to heightened urinary losses of phosphate.…”

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confidence: 99%

Suicide Case Due to Phosphoric Acid Ingestion: Case Report and Review of Literature

Aquila

Pepe

Nunzio

et al. 2014

Journal of Forensic Sciences

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Ingesting caustic substances represents a common event which may result in serious injuries of the gastrointestinal system. Severity of injury depends on the type of ingested substance: Caustic burns are more frequently associated with acid ingestion and their severity depends on type, concentration, time of exposure, and amount of the ingested substance. We report a case of phosphoric acid ingestion leading to death in a patient with depressive disorder. While reports ingestion of other acids and organophosphates can be found in the literature, there are no reports detailing a death due to phosphoric acid ingestion. We hope that presenting the findings in this case can aid death investigators in future cases that may involve ingestion of such a substance. After autopsy pH, phosphate and calcium ions concentration in the blood were analyzed. The cause of death was due to systemic effects: metabolic acidosis, hypophosphatemia, hypocalcemia, and hyperkalemia.

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Metabolic abnormalities associated with phosphoric acid ingestion

Cited by 10 publications

References 16 publications

The effect of some food additive on the liver function in laboratory animal

The effect of some food additive on the liver function in laboratory animal

A Case of Severe Acute Hyperphosphatemia Secondary to Ingestion of Phosphoric Acid Solution Treated with Continuous Renal Replacement Therapy

Suicide Case Due to Phosphoric Acid Ingestion: Case Report and Review of Literature

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