Metabolic abnormality in the right dorsolateral prefrontal cortex in patients with obsessive–compulsive disorder: proton magnetic resonance spectroscopy

Shin-Eui, Park; Choi, Nam-Gil; Jeong, Gwang‐Woo

doi:10.1017/neu.2016.48

Cited by 16 publications

(9 citation statements)

References 27 publications

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“…DLPFC is a critical area for cognitive control and executive processes, including response inhibition, behavioral flexibility, and orienting of attention. Previous studies reported brain metabolic abnormalities in OCD in the right DLPFC (Park et al ., 2017). Furthermore, clinical treatment using repetitive transcranial magnetic stimulation (TMS) targeting the right DLPFC has been shown to improve obsessive symptoms (Seo et al ., 2016).…”

Section: Discussionmentioning

confidence: 99%

Impairment in the goal-directed corticostriatal learning system as a biomarker for obsessive–compulsive disorder

et al. 2019

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BackgroundCompulsive behaviors in obsessive-compulsive disorder (OCD) have been related to impairment within the associative cortical-striatal system connecting the caudate and prefrontal cortex that underlies consciously-controlled goal-directed learning and behavior. However, little is known whether this impairment may serve as a biomarker for vulnerability to OCD.MethodsUsing resting-state functional magnetic resonance imaging (fMRI), we employed Granger causality analysis (GCA) to measure effective connectivity (EC) in previously validated striatal sub-regions, including the caudate, putamen, and the nucleus accumbens, in 35 OCD patients, 35 unaffected first-degree relatives and 35 matched healthy controls.ResultsBoth OCD patients and their first-degree relatives showed greater EC than controls between the left caudate and the orbital frontal cortex (OFC). Both OCD patients and their first-degree relatives showed lower EC than controls between the left caudate and lateral prefrontal cortex. These results are consistent with findings from task-related fMRI studies which found impairment in the goal-directed system in OCD patients.ConclusionsThe same changes in EC were present in both OCD patients and their unaffected first-degree relatives suggest that impairment in the goal-directed learning system may be a biomarker for OCD.

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Section: Discussionmentioning

confidence: 99%

Impairment in the goal-directed corticostriatal learning system as a biomarker for obsessive–compulsive disorder

et al. 2019

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“…Studies targeting cortical regions have found increased NAA/Cr[38] and decreased glutamate[44] in the medial PFC, decreased glutamate and increased myoinositol in the DLPFC,[48] and decreased NAA in the ACC,[4041] which increased after medication. [40] An older study had slightly different findings, with lower NAA concentration being found in the ACC in responders to selective serotonin reuptake inhibitors (SSRIs) with antipsychotic augmentation as compared to healthy controls, while no such differences were seen between SSRI responders and nonresponders.…”

Section: Magnetic Resonance Spectroscopymentioning

confidence: 99%

Neuroimaging findings in obsessive–compulsive disorder: A narrative review to elucidate neurobiological underpinnings

Hazari

Narayanaswamy

Venkatasubramanian

2019

Indian J Psychiatry

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Obsessive compulsive disorder (OCD) is a common psychiatric illness and significant research has been ongoing to understand its neurobiological basis. Neuroimaging studies right from the 1980s have revealed significant differences between OCD patients and healthy controls. Initial imaging findings showing hyperactivity in the prefrontal cortex (mainly orbitofrontal cortex), anterior cingulate cortex and caudate nucleus led to the postulation of the cortico-striato-thalamo-cortical (CSTC) model for the neurobiology of OCD. However, in the last two decades emerging evidence suggests the involvement of widespread associative networks, including regions of the parietal cortex, limbic areas (including amygdala) and cerebellum. This narrative review discusses findings from structural [Magnetic Resonance Imaging (MRI), Diffusion Tensor Imaging(DTI)], functional [(functional MRI (fMRI), Single photon emission computed tomography (SPECT), Positron emission tomography (PET), functional near-infrared spectroscopy (fNIRS)], combined structural and functional imaging studies and meta-analyses. Subsequently, we collate these findings to describe the neurobiology of OCD including CSTC circuit, limbic system, parietal cortex, cerebellum, default mode network and salience network. In future, neuroimaging may emerge as a valuable tool for personalised medicine in OCD treatment.

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“…The pathophysiological feature of OCD, as revealed by fMRI studies, suggest that abnormal brain metabolites may be implied in OCDs. Abnormalities in brain metabolite concentrations in patients with OCD were investigated using proton MRS [167] , [168] , [169] , [170] . Among about ten detectable metabolites, glutamate, glutamine, and GABA are of particular interest, as they are involved in neurotransmission.…”

Section: Multimodal Imaging Data Fusion: Diseasesmentioning

confidence: 99%

Advances in multimodal data fusion in neuroimaging: Overview, challenges, and novel orientation

et al. 2020

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Highlights We analysed over 450 references from all well-famed databases. We provided a comprehensive survey on multimodal data fusion in neuroimaging. This review encompassed current challenges & applications, strengths &limitations. Fundamental fusion rules, and fusion quality assessment methods were reviewed. Atlas-based fusion segmentation, quantification, & applications were reviewed.

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Metabolic abnormality in the right dorsolateral prefrontal cortex in patients with obsessive–compulsive disorder: proton magnetic resonance spectroscopy

Abstract: These findings would be helpful to understand the pathophysiology of OCD associated with the brain metabolic abnormalities in the right DLPFC.

Cited by 16 publications

References 27 publications

Impairment in the goal-directed corticostriatal learning system as a biomarker for obsessive–compulsive disorder

Impairment in the goal-directed corticostriatal learning system as a biomarker for obsessive–compulsive disorder

Neuroimaging findings in obsessive–compulsive disorder: A narrative review to elucidate neurobiological underpinnings

Advances in multimodal data fusion in neuroimaging: Overview, challenges, and novel orientation

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