2021
DOI: 10.1053/j.ajkd.2021.05.025
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Metabolic Acidosis and Hyponatremia in a Patient With Metastatic Melanoma

Abstract: A 72-year-old man with a history of metastatic melanoma and hypertension presented to the hospital with a 2-week duration of weakness and fatigue. He also reported poor appetite and decreased oral intake but no weight loss. He denied shortness of breath, lightheadedness, syncope, nausea, vomiting, or diarrhea. He also denied headache, confusion, polyuria, or polydipsia.Home medications included amlodipine 10 mg once a day, lisinopril 10 mg once a day, and pembrolizumab 200 mg intravenously every 3 weeks. The l… Show more

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Cited by 4 publications
(1 citation statement)
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“…Distal renal tubular acidosis has been reported in the setting of anti-PD-1 use (pembrolizumab or nivolumab) [60][61][62][63][64]. Herrmann et al [61] described a case series of distal RTA and stained the biopsy specimen for transporters in alpha-intercalated cells, and found decreased expression of vacuolar Hþ-ATPase and anion-exchanger 1.…”
Section: Electrolyte Disorders Associated With Immune Checkpoint Inhi...mentioning
confidence: 99%
“…Distal renal tubular acidosis has been reported in the setting of anti-PD-1 use (pembrolizumab or nivolumab) [60][61][62][63][64]. Herrmann et al [61] described a case series of distal RTA and stained the biopsy specimen for transporters in alpha-intercalated cells, and found decreased expression of vacuolar Hþ-ATPase and anion-exchanger 1.…”
Section: Electrolyte Disorders Associated With Immune Checkpoint Inhi...mentioning
confidence: 99%