Metabolic adaptation of myocardial mitochondria to mild altitude hypoxia

Gvozdjáková, A; Kucharská, J; Miklovičová, Eva; Rajecová, O; Gvozdják, J; Kaplánová, M.; Bocková, Markéta

doi:10.1016/0167-5273(92)90114-i

Cited by 4 publications

(6 citation statements)

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“…Evidence from metabolic studies and mitochondrial genetics suggested that mtDNA haplogroup may be related to AMS. Prior metabolic studies in rodents and humans exposed to hypobaric hypoxia noted changes in mitochondrial oxidative phosphorylation (OXPHOS) function, ROS production, and activation of the mitochondrial K + channel and of the mitochondrial permeability transition pore (mtPTP) (Gvozdjáková et al, 1992; Tan et al, 2002; Magalhães et al, 2005; Gonzales et al, 2005; Zhu et al, 2006). Additionally, some mtDNA haplogroups were found to be associated with human susceptibility to metabolic and degenerative diseases such as neurodegenerative diseases, diabetes, metabolic syndrome, as well as to influence the risk of cancer and longevity; and mitochondrial ROS production was considered to make an important contribution to these diseases and longevity (Wallace et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

MtDNA haplogroups M7 and B in southwestern Han Chinese at risk for acute mountain sickness

Zheng

et al. 2011

Mitochondrion

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We conducted a case-control study to investigate the association of mitochondrial DNA (mtDNA) haplogroups with acute mountain sickness (AMS) in Han Chinese from southwestern (SW) China. Pearson’s chi-square test or Fisher’s exact test revealed significant reduction of mtDNA haplogroups D and M9, while a significant increase of haplogroup M7 in AMS subjects compared with non-AMS subjects. The multivariate logistic regression analysis after adjustment for body mass index (BMI), a risk factor of AMS in the present study, showed that both D and M9 were associated with significantly decreased risk of AMS, while M7 was associated with a significantly increased risk of AMS (OR = 0.605, p = 0.000; OR = 0.037, p = 0.001, and OR = 2.419, p = 0.001, respectively). In addition, the further analysis stratified by the AMS severities indicated that haplogroup B was correlated with a 2.41-folds increased risk of developing severe AMS (95%C.I = 1.288–4.514, p = 0.006). Our findings provide the evidence that, in SW Han Chinese, mtDNA haplogroups D and M9 are related to individual tolerance to AMS, while haplogroups M7 and B are risk factors for AMS.

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Section: Introductionmentioning

confidence: 99%

MtDNA haplogroups M7 and B in southwestern Han Chinese at risk for acute mountain sickness

Zheng

et al. 2011

Mitochondrion

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“…In contrast, conflicting results have been reported with regard to cytochrome c oxidase (COX), as a specific mitochondrial marker, probably because of the variety of experimental conditions employed or the comparison between populations in which additional factors (e.g., food restriction) may be involved. When comparing high altitude‐exposed animals with sea level controls, either no change, 19,20 a decrease, 21,22 or an increase 23,24 in the specific activity of cardiac COX has been reported. The comparison of COX in the right and left ventricular myocardium is, however, almost lacking, male and female hearts having been compared only in the study of Gvozdjakova and colleagues.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The comparison of COX in the right and left ventricular myocardium is, however, almost lacking, male and female hearts having been compared only in the study of Gvozdjakova and colleagues. 22 The aim of our study was, therefore, to find out whether intermittent exposure of animals to a simulated altitude of 5,000 m influences cardiac oxidative capacity. COX was used as a marker of oxidative metabolism 25 and as an enzyme reacting to oxygen tension.…”

Section: Introductionmentioning

confidence: 99%

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Activity of Cytochrome c Oxidase in the Right and Left Ventricular Myocardium of Male and Female Rats Exposed To Intermittent High Altitude Hypoxia^a

Stieglerová

Drahota

Houštěk

et al. 1999

Annals of the New York Academy of Sciences

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The aim of the present study was to compare the capacity of the oxidative metabolism (total activity of cytochrome c oxidase, COX) in the right and left ventricular myocardium of adult rats exposed to intermittent high altitude (IHA) hypoxia simulated in a barochamber (5,000 m, 8 h/day, 5 days/wk, for a total of 32 exposures). In male and female rats, IHA induced significant increases of the right ventricular (RV) weight and protein content, whereas left ventricular (LV) weight and protein content remained unaffected. Consequently, the RV/LV ratio in both sexes markedly increased. Similarly, IHA induced an increase of the total activity of COX in RV in both sexes. The specific activities of COX in homogenate as well as in isolated mitochondria were not changed in IHA-exposed animals, which indicates that the increase of total activity of COX is proportional to the increase of total protein content and RV weight.

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“…Proposed mechanisms by which nicotine produces oxidative stress include disruption of the mitochondrial respiratory chain leading to leakage from the electron transport in cardiomyocytes of rabbits, 28) decrease in glutathione level in Chinese hamster ovary cells, 2) and decreased activities of catalase and SOD in various tissues of rat. 4) It is also shown that addition of free radical scavenging enzymes, SOD and catalase, prevent nicotine-induced increase in lipid peroxidation in pancreatic tissue of rat 1) and decrease in cellular glutathione level in Chinese hamster ovary cells.…”

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confidence: 99%

Beneficial Effects of Hippophae rhamnoides L. on Nicotine Induced Oxidative Stress in Rat Blood Compared with Vitamin E.

Süleyman

Gümüştekin

Taysı

et al. 2002

Biological & Pharmaceutical Bulletin

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The aim of this study was to determine the effects of Hippophae rhamnoides L. extract (HRe-1) and also vitamin E as a positive control on nicotine-induced oxidative stress in rat blood, specifically alterations in erythrocyte malondialdehyde (MDA) level, activities of some erythrocyte antioxidant enzymes, and plasma vitamin E and A levels. The groups were: nicotine (0.5 mg/kg/d, intraperitoneal, i.p.); nicotine؉vitamin E (75 mg/kg/d, intragastric, i.g.); nicotine؉HRe-1 (1 ml/kg/d, i.g.); and control group (receiving only vehicles). There were 8 rats per group and the supplementation period was 3 weeks. Nicotine-induced increase in erythrocyte MDA level was prevented by both HRe-1 and vitamin E. Nicotine-induced decrease in erythrocyte superoxide dismutase (SOD) activity was prevented by HRe-1, but not vitamin E. HRe-1 increased the erythrocyte glutathione peroxidase (GSH-Px) activity compared with nicotine and the vitamin E groups. Catalase activity was not affected. Vitamin E supplementation increased plasma vitamin E level. Plasma vitamin A level was higher in both vitamin E and HRe-1 supplemented groups compared with nicotine and control groups. The results suggest that HRe-1 extract can be used as a dietary supplement, especially by people who smoke, in order to prevent nicotine-induced oxidative stress.

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Metabolic adaptation of myocardial mitochondria to mild altitude hypoxia

Cited by 4 publications

References 4 publications

MtDNA haplogroups M7 and B in southwestern Han Chinese at risk for acute mountain sickness

MtDNA haplogroups M7 and B in southwestern Han Chinese at risk for acute mountain sickness

Activity of Cytochrome c Oxidase in the Right and Left Ventricular Myocardium of Male and Female Rats Exposed To Intermittent High Altitude Hypoxia^a

Beneficial Effects of Hippophae rhamnoides L. on Nicotine Induced Oxidative Stress in Rat Blood Compared with Vitamin E.

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Metabolic adaptation of myocardial mitochondria to mild altitude hypoxia

Cited by 4 publications

References 4 publications

MtDNA haplogroups M7 and B in southwestern Han Chinese at risk for acute mountain sickness

MtDNA haplogroups M7 and B in southwestern Han Chinese at risk for acute mountain sickness

Activity of Cytochrome c Oxidase in the Right and Left Ventricular Myocardium of Male and Female Rats Exposed To Intermittent High Altitude Hypoxiaa

Beneficial Effects of Hippophae rhamnoides L. on Nicotine Induced Oxidative Stress in Rat Blood Compared with Vitamin E.

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Activity of Cytochrome c Oxidase in the Right and Left Ventricular Myocardium of Male and Female Rats Exposed To Intermittent High Altitude Hypoxia^a