2022
DOI: 10.3389/fimmu.2022.945980
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Metabolic alterations impair differentiation and effector functions of CD8+ T cells

Abstract: CD8+ T lymphocytes are one of the main effector cells of the immune system, they protect the organism against intracellular threats such as viruses and bacteria, as well as neoplasms. It is currently well established that CD8+ T cells have distinct immune responses, given by their phenotypes Tc1, Tc2, Tc17, and TcReg. The cellular plasticity of such phenotypes depends on the presence of different combinations of cytokines in the extracellular medium. It is known that metabolic imbalances play an important role… Show more

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Cited by 5 publications
(2 citation statements)
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“…Metabolic deregulation is closely associated with disruption of CD8 + T cell activation and effector function [28,29]. Considering the deregulation of metabolic programs upon MMA exposure observed in the GSEA and the known effects of MMA in metabolism [30], we hypothesized that MMA-induced CD8 + T cell dysfunction is associated with alterations of metabolic pathways that empower activation and effector function.…”
Section: Mma-treated Cd8 + T Cells Exhibit Tca Cycle Abnormalities An...mentioning
confidence: 99%
“…Metabolic deregulation is closely associated with disruption of CD8 + T cell activation and effector function [28,29]. Considering the deregulation of metabolic programs upon MMA exposure observed in the GSEA and the known effects of MMA in metabolism [30], we hypothesized that MMA-induced CD8 + T cell dysfunction is associated with alterations of metabolic pathways that empower activation and effector function.…”
Section: Mma-treated Cd8 + T Cells Exhibit Tca Cycle Abnormalities An...mentioning
confidence: 99%
“…Activation of the innate immune response is essential for the subsequent induction of the adaptive immune system response [ 10 ]. This process involves the release of damage-associated molecular patterns (DAMPs), the cross-presentation of tumor antigens by dendritic cells (DCs) to T lymphocytes, and their specific anti-cancer response [ 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. Moreover, T lymphocytes can form an immune memory that provides long-term protection against cancer recurrence [ 25 ].…”
Section: Introductionmentioning
confidence: 99%