Metabolic and antioxidant markers in the plasma of sportsmen from a Mediterranean town performing non-agonistic activity

Battino, Maurizio; Amadio, Eliane Martins; Oradei, A.; Littarru, G. P.

doi:10.1016/s0098-2997(97)00022-8

Cited by 9 publications

(5 citation statements)

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“…Furthermore, the level of physical fitness may also influence antioxidant status. Indeed, other investigators have observed a negative relationship between VO 2max and plasma uric acid (Robertson et al, 1991) or plasma ␣-tocopherol (Battino et al, 1997). Such data closely agrees with a result found in our study (i.e., the negative relationship observed between W peak and resting plasma uric acid and ␣-tocopherol concentrations).…”

Section: Discussionsupporting

confidence: 93%

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Physical Fitness and Plasma Non-Enzymatic Antioxidant Status at Rest and After a Wingate Test

Groussard

Machefer²,

Rannou³

et al. 2003

Can. J. Appl. Physiol.

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We tested seven physical education students whether 30-s sprint anaerobic exercise (Wingate test) would result in oxidative stress (evaluated by lipid radical levels) sufficient to alter plasma non-enzymatic antioxidant status (plasma uric acid, ascorbic acid, alpha-tocopherol, beta-carotene). This study demonstrates that 1) Wingate test increases plasma uric and ascorbic acid concentrations (p <.05), and decreases plasma alpha-tocopherol and beta-carotene levels (p <.05); 2) lipid radical levels at rest and sprint performance are negatively correlated with resting plasma uric acid and alpha-tocopherol concentrations (p <.05). In conclusion, this study 1) demonstrates that a 30-s sprint anaerobic exercise is associated with acute changes in plasma non-enzymatic antioxidant status, 2) indicates that the subjects with largest leg peak power are those who exhibit the lowest plasma antioxidant status at rest (uric acid and alpha-tocopherol), 3) and suggests that antioxidant intake by maintaining plasma antioxidant concentration at rest in the normal range might protect athletes against oxidative stress induced by exercise.

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Section: Discussionsupporting

confidence: 93%

“…Indeed, a negative relationship was found between maximal oxygen uptake (VO 2max ) and uric acid (Robertson et al, 1991) or ␣-tocopherol concentration (Battino et al, 1997), Can. J.…”

Section: Introductionmentioning

confidence: 99%

Physical Fitness and Plasma Non-Enzymatic Antioxidant Status at Rest and After a Wingate Test

Groussard

Machefer²,

Rannou³

et al. 2003

Can. J. Appl. Physiol.

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“…Our results indicate that intense exercise produces a significant depletion in lipoprotein CoQ 10 content, that likely corresponds to an enhanced request by tissue compartments. In support of this hypothesis, on average a lower plasma CoQ 10 content in trained subjects compared to sedentary ones has been previously documented [34][35][36][37] and a positive correlation between muscular CoQ 10 content and exercise capacity has been observed [38,39]. Moreover, it is also known that statin treatment, a widely used hypocholesterolemic drug targeting cholesterol and also CoQ 10 synthesis, has been related to impaired exercise capacity [40,41] as well as to an increased incidence of intolerance in athletes and physically active patients [42,43] which further supports an increased CoQ 10 requirement in physical activity.…”

Section: Discussionmentioning

confidence: 55%

Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes

et al. 2018

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Objectives: Physical exercise significantly impacts the biochemistry of the organism. Ubiquinone is a key component of the mitochondrial respiratory chain and ubiquinol, its reduced and active form, is an emerging molecule in sport nutrition. The aim of this study was to evaluate the effect of ubiquinol supplementation on biochemical and oxidative stress indexes after an intense bout of exercise. Methods: 21 male young athletes (26 + 5 years of age) were randomized in two groups according to a double blind cross-over study, either supplemented with ubiquinol (200 mg/day) or placebo for 1 month. Blood was withdrawn before and after a single bout of intense exercise (40 min run at 85% maxHR). Physical performance, hematochemical parameters, ubiquinone/ubiquinol plasma content, intracellular reactive oxygen species (ROS) level, mitochondrial membrane depolarization, paraoxonase activity and oxidative DNA damage were analyzed. Results: A single bout of intense exercise produced a significant increase in most hematochemical indexes, in particular CK and Mb while, on the contrary, normalized coenzyme Q 10 plasma content decreased significantly in all subjects. Ubiquinol supplementation prevented exercise-induced CoQ deprivation and decrease in paraoxonase activity. Moreover at a cellular level, in peripheral blood mononuclear cells, ubiquinol supplementation was associated with a significant decrease in cytosolic ROS while mitochondrial membrane potential and oxidative DNA damage remained unchanged. Discussion: Data highlights a very rapid dynamic of CoQ depletion following intense exercise underlying an increased demand by the organism. Ubiquinol supplementation minimized exerciseinduced depletion and enhanced plasma and cellular antioxidant levels but it was not able to improve physical performance indexes or markers of muscular damage.

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“…One study showed a positive association between blood levels of Q 10 and maximal oxygen uptake (Battino et al, 1997), and non-randomised experimental studies have suggested that supplementation with Q 10 has a positive effect on physical capacity (Vanfraechem et al, 1986;Yamabe & Fukuzake, 1991). However, several of the experiments did not include a reference group, and placebo effect, information bias and confounding may have in¯u-enced the results.…”

Section: Physical Capacitymentioning

confidence: 99%

Coenzyme Q10 in health and disease

et al. 1999

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Metabolic and antioxidant markers in the plasma of sportsmen from a Mediterranean town performing non-agonistic activity

Cited by 9 publications

References 1 publication

Physical Fitness and Plasma Non-Enzymatic Antioxidant Status at Rest and After a Wingate Test

Physical Fitness and Plasma Non-Enzymatic Antioxidant Status at Rest and After a Wingate Test

Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes

Coenzyme Q10 in health and disease

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