Metabolic and cardiovascular effects of a progressive exercise test in patients with chronic fatigue syndrome

Sisto, Sue Ann; LaManca, John J.; Cordero, D.; Bergen, Michael T.; Ellis, Steven P.; Drastal, Susan; Boda, Wanda L.; Tapp, Walter N.; Natelson, Benjamin H.

doi:10.1016/s0002-9343(96)00041-1

Cited by 103 publications

(69 citation statements)

References 13 publications

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“…One particularly common and disabling symptom is the complaint that even minimal exertion produces a dramatic worsening of the entire symptom complex -with much worse fatigue, less activity, and more associated symptoms. Previously, we used paper and pencil questionnaires to investigate this complaint and have found that self-reported fatigue increased 4 days after physical exertion (1). However, the time course over which symptom worsening develops remains unknown.…”

Section: Introductionmentioning

confidence: 99%

A real-time assessment of the effect of exercise in chronic fatigue syndrome

Yoshiuchi

Cook

Ohashi

et al. 2007

Physiology & Behavior

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Patients with chronic fatigue syndrome (CFS) report substantial symptom worsening after exercise. However, the time course over which this develops has not been explored. Therefore, the objective of this study was to investigate the influence of exercise on subjective symptoms and on cognitive function in CFS patients in natural settings using a computerized ecological momentary assessment method, which allowed us to track the effects of exercise within and across days. Subjects were 9 female patients with CFS and 9 healthy women. A watch-type computer was used to collect real time data on physical and psychological symptoms and cognitive function for one week before and two weeks after a maximal exercise test. For each variable, we investigated temporal changes after exercise using multilevel modeling. Following exercise, physical symptoms did get worse but not until a five-day delay in CFS patients. Despite this, there was no difference in the temporal pattern of changes in psychological symptoms or in cognitive function after exercise between CFS patients and controls. In conclusion, physical symptoms worsened after a several day delay in patients with CFS following exercise while psychological symptoms or cognitive function did not change after exercise.

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Section: Introductionmentioning

confidence: 99%

A real-time assessment of the effect of exercise in chronic fatigue syndrome

Yoshiuchi

Cook

Ohashi

et al. 2007

Physiology & Behavior

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“…Patients with CFS are weaker than sedentary and depressed controls but also as unfit as sedentary controls [23]. Female CFS patients' aerobic power indicates a low normal fitness level without cardiopulmonary abnormality [30].…”

Section: Discussionmentioning

confidence: 99%

“…During treadmill walking, a subtle abnormality in vagal activity was noticed that could explain, in part, postexertion symptom exacerbation [29]. Female patients with CFS's aerobic power indicates a low normal fitness level without cardiopulmonary abnormality [30]. Patients with CFS are weaker than sedentary and depressed controls but also as unfit as sedentary controls [23].…”

Section: Discussionmentioning

confidence: 99%

Timed loaded standing in female chronic fatigue syndrome compared with other populations

et al. 2015

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Abstract-Patients with chronic fatigue syndrome (CFS), like patients with osteoporosis, have similar difficulties in standing and sitting. The aim of the study was to compare combined trunk and arm endurance among women with CFS (n = 72), women with osteoporosis (n = 30), nondisabled women (n = 55), and women from non-industrialized countries (n = 58) using the timed loaded standing (TLS) test. TLS measures how long a person can hold a 1 kg dumbbell in each hand in front of him or her with straight arms. TLS was higher in the industrialized nondisabled population than in the non-industrialized study population (p < 0.001) and in patients with osteoporosis (p = 0.002). TLS was lower in patients with CFS than in nondisabled controls (p < 0.001). After adjusting for age, body height, and weight, combined trunk and arm endurance was lower in CFS patients than in osteoporotic patients, even though the patients with osteoporosis were more than 25 yr older (p < 0.001). In CFS, TLS was lower than in the non-industrialized group (p = 0.02). Since only women were studied, external validity of the results is limited to adult female patients with CFS. TLS revealed a specific biomechanical weakness in CFS patients that can be taken into account from the onset of a rehabilitation program. We propose that influencing the quality, rather than the quantity, of movement could be used in the rehabilitation.Key words: chronic fatigue syndrome, deformation, endurance, graded exercise/exposure therapy, movement, nonindustrialized population, osteoporosis, physical performance, timed loaded standing, trunk.Abstract corrected from original 11/5/15: Erratum in 52(7) JRRD 2015.

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“…Subjects also rated their current fatigue at the end of the third minute of each recovery period using a 5-point fatigue scale that ranged from "none at all" to "severe." 9 After exercise. Recovery from the intermittent exercise consisted of the subjects sitting quietly for 5 minutes.…”

Section: Study Protocolmentioning

confidence: 99%

“…Some investigators [2][3][4][5] have reported that continuous exercise of sufficient intensity and duration exacerbates symptoms in patients with CFS. Sisto et al, 9 however, demonstrated that a discontinuous graded exercise test did not greatly exacerbate the underlying illness of patients with CFS. Therefore, for many patients with CFS, it is improbable that they can exercise continuously for 30 minutes without exacerbating symptoms, but it may be possible that they can perform light-intensity physical activity intermittently throughout the day to accumulate 30 minutes of exercise without exacerbating symptoms.…”

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Acute Effects of Thirty Minutes of Light-Intensity, Intermittent Exercise on Patients With Chronic Fatigue Syndrome

et al. 1999

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Background and Purpose. Currently, there is no consensus on exercise prescription for patients with chronic fatigue syndrome (CFS). This investigation examined whether light-intensity, intermittent physical activity exacerbated symptoms in patients with CFS immediately following exercise to 7 days following exercise. Subjects. Subjects were 9 women (mean ageϭ44.2 years, SDϭ8.4, rangeϭ29-56; mean weightϭ74.2 kg, SDϭ18.8, rangeϭ56.36-110.91; and mean heightϭ1.63 m, SDϭ0.8, rangeϭ1.55-1.78) and 1 man (ageϭ48 years, weightϭ97.1 kg, and heightϭ1.98 m) who met the Centers for Disease Control and Prevention's criteria for CFS. Methods. Subjects performed 10 discontinuous 3-minute exercise bouts (separated by 3 minutes of recovery) at a self-selected, comfortable walking pace on a treadmill. Oxygen consumption, minute ventilation, respiratory exchange ratio, and heart rate were measured every minute during the exercise session. To assess degree of disability, general health status, activity level, symptoms, and mood, subjects completed various questionnaires before and after exercise. Results. Results indicated that degree of disability, general health status, symptoms, and mood did not change immediately and up to 7 days following exercise. Conclusion and Discussion. Thirty minutes of intermittent walking did not exacerbate symptoms in subjects with CFS. The physiological data did not show any abnormal response to exercise. Although this study did not determine whether 30 minutes of continuous versus intermittent exercise would exacerbate symptoms, all 10 subjects felt that they could not exercise continuously for 30 minutes without experiencing symptom exacerbation. Despite this limitation, the results indicate that some individuals with CFS may be able to use low-level, intermittent exercise without exacerbating their symptoms. [Clapp LL, Richardson MT, Smith JF, et al. Acute effects of thirty minutes of light-intensity, intermittent exercise on patients with chronic fatigue syndrome. Phys Ther. 1999;79:749-756.]

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Metabolic and cardiovascular effects of a progressive exercise test in patients with chronic fatigue syndrome

Cited by 103 publications

References 13 publications

A real-time assessment of the effect of exercise in chronic fatigue syndrome

A real-time assessment of the effect of exercise in chronic fatigue syndrome

Timed loaded standing in female chronic fatigue syndrome compared with other populations

Acute Effects of Thirty Minutes of Light-Intensity, Intermittent Exercise on Patients With Chronic Fatigue Syndrome

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