Metabolic and Genetic Association of Vitamin D with Calcium Signaling and Insulin Resistance

Tarfeen, Najeebul; Nisa, Khair Ul; Ahmad, Mir Bilal; Waza, Ajaz Ahmad; Ganai, Bashir Ahmad

doi:10.1007/s12291-022-01105-0

Cited by 8 publications

(3 citation statements)

References 115 publications

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“…Vitamin D action is mediated by a ubiquitous vitamin D receptor present in all nucleated cells. Given the widespread distribution of vitamin D receptors, which extend to the colon, osteoblasts, activated T and B lymphocytes and mononuclear cells, beta islet cells, brain, heart, skin, gonads, prostate, and breasts, it is anticipated that vitamin D deficiency will manifest in various extra-skeletal effects [26][27][28], such as an increased risk to the development of cardiovascular conditions, malignancies, immune system disorders, infections, chronic respiratory illnesses, and cognitive impairments [26][27][28][29][30][31]. For this reason, it is essential to promptly identify instances of vitamin D deficiency in order to mitigate these health concerns in children by preferably utilizing a non-invasive and cost-effective tool for their comfort.…”

Section: Discussionmentioning

confidence: 99%

An Adapted Questionnaire Tailored for Assessing the Risk of Vitamin D Deficiency in Children That Is Proving Useful in Guiding Clinical Interventions

Calcaterra,

Cena,

De Giuseppe

et al. 2024

Nutrients

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Background: The identification of vitamin D (VitD) deficiency in pediatric populations is essential for preventive healthcare. We refined and tested the Evaluation of Deficiency Questionnaire (EVIDENCe-Q) for its utility in detecting VitD insufficiency among children. Patients and methods: We enrolled 201 pediatric patients (aged between 3 and 18 years). Clinical evaluation and serum vitamin D levels were assessed in all subjects. The EVIDENCe-Q was updated to incorporate factors influencing VitD biosynthesis, intake, assimilation, and metabolism, with scores spanning from 0 (optimal) to 36 (poor). Results: We established scores for severe deficiency (<10 mg/dL) at 20, deficiency (<20 mg/dL) at 22, and insufficiency (<30 mg/dL) at 28. A score of 20 or greater was determined as the optimal cut-off for distinguishing VitD deficient from sufficient statuses, as evidenced by ROC curve analysis AUC = 0.7066; SE = 0.0841; sensitivity 100%, 95% CI 0.561–1. The most accurate alignment was seen with VitD insufficiency, defined as 25-OH-D3 < 20 ng/mL. Conclusions: This study confirms that the EVIDENCe-Q is a valid instrument for assessing the risk of vitamin D deficiency and insufficiency in children. It offers a practical approach for determining the need for clinical intervention and dietary supplementation of VitD in the pediatric population.

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Section: Discussionmentioning

confidence: 99%

An Adapted Questionnaire Tailored for Assessing the Risk of Vitamin D Deficiency in Children That Is Proving Useful in Guiding Clinical Interventions

Calcaterra,

Cena,

De Giuseppe

et al. 2024

Nutrients

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“…This underscores the regulatory role of calcium, influenced by vitamin D intake and feedback from the kidneys to retain calcium through parathyroid hormone. Vitamin D also functions in an autocrine manner in the RAAS and contributes to calcium retention [25,26,52,53].…”

Section: Materials and Methods Subjects And Data Collec-mentioning

confidence: 99%

Relationship between fibroblast growth factor 23 level and vitamin D status in chronic kidney disease: A cross-sectional study

Ratu,

Rasyid,

Bakri

et al. 2024

Ukr. J. Nephrol. Dial.

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Complications stemming from chronic kidney disease (CKD) significantly contribute to increased morbidity and mortality rates. During the early stages of CKD, a delicate balance in homeostasis and mineral regulation is maintained largely due to fibroblast growth factor 23 (FGF-23). However, as kidney function declines, there is a detrimental effect on vitamin D synthesis. Understanding the dynamics of FGF-23 levels in relation to vitamin D status is crucial for assessing kidney function and its implications on hormonal regulation, calcium homeostasis, and cardiovascular health. Therefore, this study aimed to scrutinize and comprehend the correlation between FGF-23 levels and vitamin D status in patients afflicted with CKD. Methods. A cross-sectional study was undertaken at Dr. Wahidin Sudirohusodo Hospital in Makassar, South Sulawesi, Indonesia, involving 58 patients diagnosed with stage 3-5 non-dialysis CKD. Relationships between FGF-23 level with vitamin D level status and CKD stage were analyzed by chi-square and Kruskal-Wallis test. Results. The FGF-23 levels, with a median of 100 pg/mL as the designated cut-off, exhibit significance concerning the levels of vitamin D (p=0.003). The average values of FGF-23 in cases of deficiency and insufficiency are markedly elevated when compared to patients with sufficient vitamin D levels (p=0.016). The significance of FGF-23 levels becomes more prominent with advancing CKD stages (p=0.06). Conclusions. FGF-23 is a related marker with vitamin D deficiency in patients with CKD but is inconsistent in stage development and not an independent factor.

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“…Dryness, acne, psoriasis, eczema, and vitiligo are just a few of the skin diseases that can be treated using vitamin D's excellent anti-inflammatory qualities [43]. By increasing insulin receptors or the sensitivity of insulin receptors to insulin, as well as by having an impact on peroxisome proliferator-activated receptors (PPAR) and the regulation of extracellular calcium, vitamin D improves insulin sensitivity [44]. A few marketed supplements of vitamin D are included in the following Table 5.…”

Section: Applications Of Vitamin Dmentioning

confidence: 99%

The Effects of Vitamin D on Preventing Hyperglycemia and a Novel Approach to Its Treatment

Monapati,

Kaki,

Gurajapu

et al. 2023

DDC

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The dietary reference levels for vitamin D were established with an emphasis on its role in bone health; however, with the identification of vitamin D receptors in all body tissues novel associations with other metabolic disorders, such as diabetes, are being researched. Aside from its standard function as the main regulator of calcium absorption, vitamin D also controls the calcium pool, mediates the activity of beta cell calcium-dependent endopeptidases, encourages the conversion of proinsulin to insulin, increases insulin output, and raises insulin activity in peripheral insulin target tissues. Both immune cells and pancreatic beta cells include vitamin D receptors. A deficiency of vitamin D causes glucose intolerance and affects insulin secretion. Different pathogenic characteristics of the disease are linked to a number of vitamin D-related genes. It has been proven that vitamin D supplementation lowers the risk of type 1 and type 2 diabetes and its associated problems. In this article, we discussed a few prospective clinical trials on vitamin D that are necessary to clearly demonstrate the role of vitamin D in the prevention and management of diabetes.

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Metabolic and Genetic Association of Vitamin D with Calcium Signaling and Insulin Resistance

Cited by 8 publications

References 115 publications

An Adapted Questionnaire Tailored for Assessing the Risk of Vitamin D Deficiency in Children That Is Proving Useful in Guiding Clinical Interventions

An Adapted Questionnaire Tailored for Assessing the Risk of Vitamin D Deficiency in Children That Is Proving Useful in Guiding Clinical Interventions

Relationship between fibroblast growth factor 23 level and vitamin D status in chronic kidney disease: A cross-sectional study

The Effects of Vitamin D on Preventing Hyperglycemia and a Novel Approach to Its Treatment

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