Metabolic and Hormonal Changes after Sleeve Gastrectomy and Mini Gastric Bypass in a Rat Model of Induced Type 2 Diabetes Mellitus and Obesity

Abstract

Introduction: Obesity is one of the leading causes of social, economic and health problems throughout the world and in the past years bariatric surgery has emerged as a method to alleviate this problem. We have conducted an experimental study aimed at comparing the metabolic and hormonal changes after sleeve gastrectomy and mini gastric bypass , two bariatric procedures showing promising results. Material and Methods: We have designed a study using a rat model with induced type 2 diabetes mellitus and obesity divided into three groups: a sleeve gastrectomy group, a mini gastric bypass group and a sham operated group, all of which had their glycemia, lipid profile, ghrelin and insulin levels measured before and after the procedures. Results: The results showed a significant decrease (p<0.05) in fasting glucose levels, lipid profile and ghrelin levels in the mini gastric bypass compared to the sleeve gastrectomy group. Conclusions: This study has demonstrated that both SG and MGB are effective treatments for morbid obesity and T2DM and both procedures can significantly resolve obesity-related metabolic changes.

The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways: Crosstalk on Perioperative Antioxidant Therapy

“…Another site for excessive ROS production is the alveolar macrophage. The reperfusion phase is characterized by pro-inflammatory cytokine release, the activation of NOS, and neutrophile recruitment [ 73 , 74 , 75 , 76 , 77 , 78 ] ( Figure 1 ).…”

Effect of COVID-19 pandemic on hospital admission rates of patients with malnutrition and/or neuromuscular complications after bariatric surgery

“…8 Evidence suggests a malabsorptive component in SG, as its benefits exceed those of only a smaller stomach, with improvement in obesity-related comorbidities that are superior or comparable to those of other restrictive procedures. 64 After SG, there is a risk of multivitamin/ mineral deficiencies due to poor food choices, food intolerance, microbiota changes, decreased hydrochloric acid, and intrinsic factors leading to B12 malabsorption. 11,[65][66][67][68][69] Regarding length of hospital stay, we found no differences before and during the pandemic.…”

The Impact of General Anesthesia on Redox Stability and Epigenetic Inflammation Pathways. Crosstalk on Perioperative Antioxidant Therapy

“…Another site for excessive ROS production is the alveolar macrophage. The reperfusion phase is characterized by pro-inflammatory cytokine release, the activation of NOS, and neutrophile recruitment [73][74][75][76][77][78] (Figure 1). Following reperfusion, a number of other biological mechanisms responsible for increasing proinflammatory status (e.g., NF-κB activation), platelet activation, and neutrophil activation.…”