Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study

Mohamed, Amal Ahmed; Ahmed, Eman M.; Bedair, Nermeen Ibrahim; Bassiouny, Dina M.; Daifalla, Aliaa E. M.; Behairy, Ola Galal; Fawazy, Naglaa; Soda, Mohamed F Al; Farag, Youssef M.K.

doi:10.1186/s43054-021-00083-x

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…78,79 Moreover, the impact of AD on diabetes mellitus is also evidenced by elevated serum insulin and fasting blood glucose levels in children with AD compared to those without AD (glucose:143.2 ± 30.3 vs 100.8 ± 16.0, p < 0.0001; serum insulin:11.3 ± 4.4 vs. 4.6 ± 3.0, p < 0.001). 80 Collectively, these data indicate that AD increases the risk of both T1DM and T2DM.…”

Section: Ad Increases the Risk Of Diabetes Mellitusmentioning

confidence: 87%

“…The incidence of diabetes mellitus positively correlated with both the duration (standardized prevalence ratio = 1.38, 95% CI:1.37–1.39 for 1 year history of AD; standardized prevalence ratio = 1.48, 95% CI:1.47–1.49 for 2‐ to 5‐year history of AD; standardized prevalence ratio = 1.71, 95% CI:1.70–1.72 for 6‐year history of AD) and severity of AD (prevalence:7.0% for mild AD, 11.7% for moderate AD and 22.9% for severe AD) 78,79 . Moreover, the impact of AD on diabetes mellitus is also evidenced by elevated serum insulin and fasting blood glucose levels in children with AD compared to those without AD (glucose:143.2 ± 30.3 vs 100.8 ± 16.0, p < 0.0001; serum insulin:11.3 ± 4.4 vs. 4.6 ± 3.0, p < 0.001) 80 . Collectively, these data indicate that AD increases the risk of both T1DM and T2DM.…”

Section: Interplay Between Ad and Diabetes Mellitusmentioning

confidence: 99%

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Interplay between diabetes mellitus and atopic dermatitis

Lei,

Zhang,

Zhu

et al. 2024

Experimental Dermatology

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Inflammatory dermatoses such as atopic dermatitis (AD) have long been linked to the pathogenesis of diabetes mellitus. Indeed, numerous studies show an increased risk of diabetes mellitus in individuals with AD although lower prevalence of diabetes mellitus is also observed in few studies. Though the underlying mechanisms accounting for the reciprocal influence between these two conditions are still unclear, the complex interplay between diabetes mellitus and AD is attributable, in part, to genetic and environmental factors, cytokines, epidermal dysfunction, as well as drugs used for the treatment of AD. Proper management of one condition can mitigate the other condition. In this review, we summarize the evidence of the interaction between diabetes mellitus and AD, and discuss the possible underlying mechanisms by which these two conditions influence each other.

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Section: Ad Increases the Risk Of Diabetes Mellitusmentioning

confidence: 87%

Section: Interplay Between Ad and Diabetes Mellitusmentioning

confidence: 99%

Interplay between diabetes mellitus and atopic dermatitis

Lei,

Zhang,

Zhu

et al. 2024

Experimental Dermatology

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“…Both represent chronic conditions that rely on a perpetual inflammatory background. Various proinflammatory cytokines secreted in the adipose tissue (e.g., tumor necrosis factor (TNF)-alpha, interleukin (IL)-6) [12,18] have a pathogenic role in AD [19]. Moreover, some adipokines with central roles in promoting obesity are found in connection with AD.…”

Section: Discussionmentioning

confidence: 99%

Association Between Increased Body Mass Index (BMI) and Atopic Dermatitis in Children Attending a Tertiary Referral Center: A Case-Control Study

Sendrea,

Cristea,

Salavastru

2024

Cureus

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Background Atopic dermatitis (AD) and obesity represent chronic diseases, with growing worldwide prevalence, that rely on a common pathophysiological background: perpetual inflammation. Moreover, AD is considered more and more to be a beyond-the-skin disease with various associated comorbidities. This study aimed to investigate a potential link between overweight/obese status and AD in children. Methods A case-control study was performed on 130 AD patients and 130 exact age and sex match controls that attended the Pediatric Dermatology Department of Colentina Clinical Hospital. Based on the weight (in kilograms) and height (in centimeters), the body mass index (BMI), and the corresponding age and gender percentiles were assessed in both groups; study participants were divided as normal-weight, underweight, overweight, or obese. AD severity was evaluated using the Scoring Atopic Dermatitis Index (SCORAD), and quality of life impairment was assessed with the Dermatology Life Quality Index (DLQI). Descriptive statistics, t-tests, and logistic regression with odds ratios (OR) and associated 95% confidence intervals (CI) were used for data analysis. Results A statistically significantly higher BMI was identified in the AD group compared to controls (p=0.027). The relative risk for overweight/obese status in the AD group compared to controls was three times more frequent (OR 3.61, 95% CI 1.45-10.3, p<0.01). Additionally, the increased BMI in the AD group correlated significantly with disease severity as determined by SCORAD (p<0.05), with a relative risk for overweight/obese status in the moderate-severe AD subgroup being 20 times more frequent as compared to mild AD (OR 20.4, 95% CI 6.53-90.7, p<0.001). Conclusions To our knowledge, this is the first study to evaluate the correlation between AD and BMI in Romanian children. Statistically significant correlations between increased BMI, AD development, and AD severity in children were identified in our study population. This study's small sample size and single-center study design represent possible limitations. Additional, larger, multicentric studies are required to establish a more precise correlation between AD and obesity. Physicians should be aware of this potential association in order to perform obesity screening in AD children for more appropriate multidisciplinary management of such patients.

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“…AD, though primarily affecting the skin, may be associated with systemic metabolic abnormalities, including metabolic syndrome (MetS), characterized by central obesity, high blood pressure, elevated fasting blood sugar (FBS), high triglyceride (TG) levels, and low high-density lipoprotein (HDL) cholesterol, that are increasingly prevalent in children. 1 The association between psoriasis and MetS is well-established, but recent research has shown an increasing interest in investigating the connection between AD and metabolic abnormalities. 2,3 The association of NAFLD with AD in children has been scarcely studied.…”

Section: Introductionmentioning

confidence: 99%

Increased prevalence of metabolic syndrome and non‐alcoholic fatty liver disease in children with atopic dermatitis: A case–control study from northern India

Reddy,

Mahajan,

Mehta

et al. 2024

Pediatric Dermatology

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Background/ObjectivesAtopic dermatitis (AD) is a chronic inflammatory skin disorder that affects children worldwide, with potential associations to metabolic syndrome (MetS) and non‐alcoholic fatty liver disease (NAFLD). Limited research exists on the interplay between AD, MetS, and NAFLD in the pediatric population. This study aimed to investigate the prevalence and potential relationships among AD, MetS, and NAFLD in children.MethodsA case–control study design was employed, recruiting 50 children with AD (median age: 9.5 years) and 50 age‐ and sex‐matched healthy controls (median age: 11.5 years, p = .051). Data on demographic characteristics, clinical features, disease severity, treatment history, anthropometric measurements, and laboratory evaluations were collected. MetS and NAFLD were diagnosed based on established criteria.ResultsThe prevalence of MetS was significantly higher in children with AD compared with controls (24% vs. 2%, p = .002). Significant differences for systolic blood pressure (p < .001), diastolic blood pressure (p = .012), and waist circumference (p = .040) were observed between AD patients and controls. Children with AD had higher triglyceride levels (p = .005). NAFLD was exclusively seen in moderate to severe AD cases (6% vs. 0%, p = .242). AD severity showed associations with increased body mass index (p = .020).ConclusionThis study highlights the increased prevalence of MetS and the potential association with NAFLD in children with AD. The findings suggest that AD may contribute to the development of metabolic abnormalities at an early age. Further research is needed to elucidate the underlying mechanisms and explore preventive strategies for these interconnected conditions.

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Metabolic and inflammatory biomarkers in children with atopic dermatitis (AD): a case-control study

Cited by 3 publications

References 26 publications

Interplay between diabetes mellitus and atopic dermatitis

Interplay between diabetes mellitus and atopic dermatitis

Association Between Increased Body Mass Index (BMI) and Atopic Dermatitis in Children Attending a Tertiary Referral Center: A Case-Control Study

Increased prevalence of metabolic syndrome and non‐alcoholic fatty liver disease in children with atopic dermatitis: A case–control study from northern India

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