Metabolic and Nutritional Status Changes After 10% WeightLoss in Severely Obese Patients Treated with Laparoscopic Surgery vs Integrated Medical Treatment

Genio, Federica del; Alfonsi, L.; Marra, Maurizio; Finelli, Carmine; Genio, Gianmattia del; Rossetti, Gianluca; Genio, A. Del; Contaldo, Franco; Pasanisi, Fabrizio

doi:10.1007/s11695-007-9286-9

Cited by 32 publications

(25 citation statements)

References 33 publications

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“…Dietary history, food habits, and previous weight loss efforts were accurately evaluated by means of an interview. All participants completed a standardized dietary support program for 4 months before being enrolled in the study, as described elsewhere [10]. In brief, at the first visit, patients were instructed by the dietician on how to fill in their food and activity diaries.…”

Section: Subject Characteristicsmentioning

confidence: 99%

“…Each patient was seen on a biweekly basis. Initial assessment included anthropometric measurements, hematobiochemical examination, homeostasis model assessment, analysis of body composition, as previously described [10].…”

Section: Subject Characteristicsmentioning

confidence: 99%

“…Measurements were performed at an ambient temperature of 22-24°C after voiding and after being in the supine position for 20 min. Height, sex, and age were entered manually; weight was recorded automatically with 0.5 kg as an adjustment for weight of clothes [10,11]. The Tanita software uses in-built prediction equations to estimate fat mass (FM) and fat-free mass (FFM).…”

Section: Anthropometric Measurementsmentioning

confidence: 99%

“…Patients were considered eligible after evaluation of esophagogastroduodenoscopy, spirometry, and abdominal ultrasound. Patients with type 2 diabetes and hypertension were excluded [10].…”

Section: Anthropometric Measurementsmentioning

confidence: 99%

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Morbid Obesity is Associated to Altered Fatty Acid Profile of Erythrocyte Membranes

Genio¹

2015

J Diabetes Metab

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Background: Morbid obesity is a pathologic condition associated to an increased incidence of several chronic conditions associated to increased risk of mortality. Erythrocyte fatty acid composition has been candidate as a biomarker of oxidative stress and consequently on the rate of aging and ultimately lifespan. To our knowledge, no study has investigated the total spectrum of lipid composition of erythrocyte membranes from obese individuals. The aim of this study was to compare the fatty acid composition of erythrocyte membranes derived from morbidly obese patients with healthy matched controls and long-living descendants.Methods: Gas chromatography was employed to determine fatty acid percentage of erythrocyte membranes from investigated groups.Results: Erythrocyte membranes from obese subjects had significantly lower percentage of monounsaturated fatty acids (16.0 ± 0.8 vs. 23.0 ± 4.5, p<0.01) and total trans fatty acid (0.2 ± 0.1 vs. 1.3 ± 1.2, p<0.001) than controls. Obese fatty acid profiles showed increased percent of total polyunsaturated fatty acid (36.5 ± 1.4 vs. 27.3 ± 10.9, p<0.001), polyunsaturated fatty acid n-3 (5.2 ± 0.9 vs. 2.6 ± 1.8, p <0.001) and n-6 (31.3 ± 1.7 vs. 25.0 ± 10.1, p<0.001). Interestingly, when obese fatty acid profiles are compared with long-living descendants, the former show opposite trends in the percentages of the main saturated and unsaturated residues of membrane phospholipids compared with nonagenarian offspring. Conclusion:This study shows that the erythrocyte membranes fatty acid composition of obese subjects differs from general population in a way opposite to the long-living descendants. If confirmed by further investigations, the fatty acid equilibration may become an additional target in the multidisciplinary strategy aimed to treat the obesity epidemic.

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Section: Subject Characteristicsmentioning

confidence: 99%

Section: Subject Characteristicsmentioning

confidence: 99%

Section: Anthropometric Measurementsmentioning

confidence: 99%

“…Patients were considered eligible after evaluation of esophagogastroduodenoscopy, spirometry, and abdominal ultrasound. Patients with type 2 diabetes and hypertension were excluded [10].…”

Section: Anthropometric Measurementsmentioning

confidence: 99%

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Morbid Obesity is Associated to Altered Fatty Acid Profile of Erythrocyte Membranes

Genio¹

2015

J Diabetes Metab

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“…35 A 10% weight loss took 6 weeks for RYGB patients versus 30 weeks for patients in a nonsurgical group (hypocaloric diet and lifestyle intervention). 36 Comparisons between weight loss via surgery versus weight loss via diet-exercise-behavioral intervention must be carefully interpreted given that surgery dramatically reduces caloric intake while other types of interventions are harder to enforce. However, there is evidence indicating that a negative energy balance via caloric restriction is not responsible for all the weight loss in bariatric surgery and for maintenance of that weight loss.…”

Section: Caloric Restriction Per Sementioning

confidence: 99%

Mechanisms Responsible for Excess Weight Loss after Bariatric Surgery

Ionut

Bergman

2011

J Diabetes Sci Technol

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Obesity has increased alarmingly in the United States and is increasing in many countries of the world. Because obesity is an important risk factor for type 2 diabetes and other chronic diseases, it is important to develop approaches to counter the rapid increase in adiposity. One approach is bariatric surgery, the most successful clinical intervention known for treating obesity. Surgery can result in impressive weight loss and improvement of obesity-related comorbidities. Yet the mechanisms responsible for this remarkable effect of surgery remain controversial. It is now clear that caloric restriction, per se, does not explain all the reduction in stored fat mass after surgery. A number of gastrointestinal hormones, including glucagon-like peptide (GLP)-1, peptide YY, oxyntomodulin, GLP-2, glucose-dependent insulinotropic polypeptide, ghrelin, and others, can play roles in energy homeostasis and could be involved in bariatric-surgery-related weight loss and weight loss maintenance. Vagal innervation may play a role. In addition, there may be other yet-uncharacterized factors that could participate. This review discusses the possible roles of these hormonal mechanisms in various types of bariatric surgery to help elucidate some of the potential mechanisms at play in short-term and long-term post-bariatric surgery weight loss. Understanding such mechanisms could lead to new and efficacious means to control or even reduce the epidemic of obesity.

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Dietetic-led management of patients undergoing laparoscopic gastric banding: early results

et al. 2009

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Metabolic and Nutritional Status Changes After 10% WeightLoss in Severely Obese Patients Treated with Laparoscopic Surgery vs Integrated Medical Treatment

Cited by 32 publications

References 33 publications

Morbid Obesity is Associated to Altered Fatty Acid Profile of Erythrocyte Membranes

Morbid Obesity is Associated to Altered Fatty Acid Profile of Erythrocyte Membranes

Mechanisms Responsible for Excess Weight Loss after Bariatric Surgery

Dietetic-led management of patients undergoing laparoscopic gastric banding: early results

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