Metabolic and Pharmacological Studies

Bender, David A.

doi:10.1007/978-94-009-4832-7_5

Chemistry and Biochemistry of the Amino Acids 1985

DOI: 10.1007/978-94-009-4832-7_5

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Metabolic and Pharmacological Studies

David A. Bender¹

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Cited by 6 publications

(2 citation statements)

References 183 publications

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“…Tryptophan is a neutral, aromatic amino acid essential for the growth of animals and human beings. It is very important in the control of brain function, given its behavior as a precursor of neurotransmitters or other important metabolic intermediates in the central nervous system (20).…”

mentioning

confidence: 99%

Synthesis, characterization and surface properties of 1‐N‐l‐tryptophan‐glycerol‐ether surfactants

Pegiadou

Pérez

Infante

2000

J Surfact & Detergents

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A novel homologous series of 1-N-L-tryptophanglycerol-ether surfactants was synthesized and characterized. The precursor compounds, 3-alkyloxy-1-chloropropan-2-ols, were prepared from epichlorohydrin and aliphatic alcohols with alkyl chain lengths of 9-16 carbon atoms. Tryptophan was then attached to the monosubstituted glycerol backbone from its αamino group through an α-NH-C bond. Structural assignment of the new compounds was made on the basis of elemental analysis and spectroscopic data. Critical micelle concentrations of the new surfactants, as well as the negative logs of the surfactant concentrations required to reduce the surface tension of the solvent by 20 mN/m (pC 20 ) and the interfacial areas occupied by the surfactant molecules, were calculated from aqueous surface tension measurements using the Wilhelmy plate technique.

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mentioning

confidence: 99%

Synthesis, characterization and surface properties of 1‐N‐l‐tryptophan‐glycerol‐ether surfactants

Pegiadou

Pérez

Infante

2000

J Surfact & Detergents

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“…In animal studies, C-labeled dietary amino acids at high specific activity have been used for a long time to analyse the fate of their C-skeleton (Bender, 1985). Insects and especially aphids have numerous advantages over vertebrates in such experiments.…”

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confidence: 99%

Analysis of energetic amino acid metabolism inAcyrthosiphon pisum: A multidimensional approach to amino acid metabolism in aphids

Febvay

Liadouze

Guillaud

et al. 1995

Arch Insect Biochem Physiol

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Aphids are highly specialized insects that feed on the phloem-sap of plants, the amino acid composition of which is very unbalanced. Amino acid metabolism is thus crucial in aphids, and we describe a novel investigation method based on the use of 14C-labeled amino acids added i n an artificial diet. A metabolism cage for aphids was constructed, allowing for the collection and analysis of the radioactivity incorporated into the aphid body, expired as COz, and rejected in the honeydew and exuviae. This method was applied to the study of the metabolism of eight energetic amino acids (aspartate, glutamate, glutamine, glycine, serine, alanine, proline, and threonine) in the pea aphid, Acyrthosiphon pisum. All these amino acids except threonine were subject to substantial catabolism as measured by high 14C02 production. The highest turnover was displayed by aspartate, with 60% of its carbons expired as COz. For the first time in an aphid, we directly demonstrated the synthesis of three essential amino acids (threonine, isoleucine, and lysine) from carbons of common amino acids. The synthesis of these three compounds was only observed from amino acids that were previously converted into glutamate. This conversion was important for aspartate, and lower for alanine and proline. To explain the quantitative results of interconversion between amino acids, we propose a compartmentation model with the intervention of bacterial endosymbiotes for the synthesis of essential amino acids and with glutamate as the only amino acid supplied by the insect to the symbiotes. Moreover, proline exhibited partial conversion into arginine, and it is suggested that proline is probably indirectly involved in excretory nitrogen metabolism. o 1995 WiIey-Liss, Inc.Key words: Homoptera, Aphididae, amino acid metabolism, symbiosis, radioactive labeling, essential amino acids, glutamate Acknowledgments: We thank G. Duport who helped with the insect cultures. We are grateful to Y. Rahbe and B. Delobel for helpful discussions and comments o n the manuscript. We also thank the Conseil Regional Rh6ne-Alpes for financial support.

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B vitamins in the nervous system

Bender

1984

Neurochemistry International

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Metabolic and Pharmacological Studies

Cited by 6 publications

References 183 publications

Synthesis, characterization and surface properties of 1‐N‐l‐tryptophan‐glycerol‐ether surfactants

Synthesis, characterization and surface properties of 1‐N‐l‐tryptophan‐glycerol‐ether surfactants

Analysis of energetic amino acid metabolism inAcyrthosiphon pisum: A multidimensional approach to amino acid metabolism in aphids

B vitamins in the nervous system

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