Metabolic and toxicological studies on cobalt

Edel, J.; Pozzi, Giovanni; Sabbioni, E.; Pietra, R.; Devos, Steven A.

doi:10.1016/0048-9697(94)90159-7

Cited by 24 publications

(19 citation statements)

References 13 publications

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“…This was accompanied by interstitial lymphocytic infiltration and intra-alveolar accumulation of neutrophils and eosinophils. Edel et al 24 looked into the short-and longterm toxicological and metabolic effects of cobalt in rats. Those researchers found that the highest concentrations of cobalt after 24 hours of intravenous administration were in the lung and large intestine.…”

Section: Animal Studiesmentioning

confidence: 99%

“…Failure to identify tungsten in tissue samples from GIP patients is reported in the literature. 24 Over the past few decades, there has been a shift from open-lung biopsies to smaller transbronchial biopsies for clinical diagnosis in pulmonology. This could be the reason for our identifying several transbronchial biopsy cases (n ϭ 6) with detectable tungsten in the biopsy tissue but insufficient sampling for a diagnosis of GIP.…”

Section: Gip As the Histologic Manifestation Of Hmdmentioning

confidence: 99%

“…96 Extensive surveillance programs, such as that undertaken with Danish pottery painters, 97 should be in effect where exposure to cobalt and other hard metals is possible. 24 The Danish pottery painter surveillance found a reduction in the urinary level of cobalt due to improvement in working environment. A regular health surveillance should include inquiring about specific complaints, pulmonary function tests, and urinary cobalt estimation.…”

Section: Clinical Aspects and Diagnosismentioning

confidence: 99%

“…99 The literature on cemented WC was extensively reviewed in a 1977 NIOSH criteria document. 24 NIOSH has recommended several measures for controlling worker exposure and establishing medical and environmental monitoring programs. Some of the recommendations relate to engineering controls, work practices, clothing and protective equipment, education, and medical surveillance.…”

Section: Clinical Aspects and Diagnosismentioning

confidence: 99%

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Pathologic Spectrum and Lung Dust Burden in Giant Cell Interstitial Pneumonia (Hard Metal Disease/Cobalt Pneumonitis): Review of 100 Cases

Naqvi

Hunt²,

Burnett³

et al. 2008

Archives of Environmental & Occupational Health

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Hard metal disease (HMD), the interstitial lung disease caused by dusts in the cemented tungsten carbide (WC) industry, has been attributed to cobalt. The rare histologic pattern of giant cell interstitial pneumonia (GIP) is characteristic in HMD. The authors reviewed the history of HMD and 100 cases of HMD that they have seen over 5 decades. GIP was proven in 59; analysis of the lung inorganic particle burden by scanning electron microscopy and energy-dispersive x-ray spectroscopy confirmed HMD in the other 41. Cases have been diagnosed by bronchoalveolar lavage, lung biopsy, and autopsy. Histopathology findings range from focal peribronchiolar inflammation to diffuse interstitial fibrosis and honeycombing. GIP cases in the WC industry reveal elevated concentrations of tungsten in all, but cobalt was detected in only 6 ( approximately 10%). Of the 746 diverse cases in the authors' analytical database, almost all cases with the highest tungsten concentration showed GIP. This study confirms that GIP is effectively pathognomonic for HMD.

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Section: Animal Studiesmentioning

confidence: 99%

Section: Gip As the Histologic Manifestation Of Hmdmentioning

confidence: 99%

Section: Clinical Aspects and Diagnosismentioning

confidence: 99%

Section: Clinical Aspects and Diagnosismentioning

confidence: 99%

See 2 more Smart Citations

Pathologic Spectrum and Lung Dust Burden in Giant Cell Interstitial Pneumonia (Hard Metal Disease/Cobalt Pneumonitis): Review of 100 Cases

Naqvi

Hunt²,

Burnett³

et al. 2008

Archives of Environmental & Occupational Health

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“…[11] Chronic exposure of male mice to cobalt chloride dramatically affected their reproductive potential, while acute administration had minimal effects. Acute exposure, followed by weekly evaluation over a 7-week period, revealed no significant changes in epididymal sperm concentration or testicular weight.…”

Section: Resultsmentioning

confidence: 99%

Cobalt-induced alterations in hamster testes in vivo

Lukáč

Massányi

Zakrzewski

et al. 2007

Journal of Environmental Science and Health, Part A

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The purpose of this study was to assess the effects of cobalt on the testicular structure of adult golden hamsters. Hamsters in group A received cobalt (CoCl2) in single intraperitoneal dose 20 mg/kg, in group B 10 mg/kg and in group C 5 mg CoCl2/kg body weight and were killed fourty eight hours after cobalt administration. Afer a preparation of histological samples the results were compared with control. After a cobalt administration dilatation of blood capillaries in interstitium, undulation of basal membrane and occurrence of empty spaces in seminiferous epithelium was detected. Morphometric analysis showed that in all cobalt-treated groups the relative volume of seminiferous epithelium was significantly decreased. In the relative volume of interstitium a significant increase was found between control group and experimental groups. After cobalt administration we have found linear non-significant decrease. Evaluation of diameter seminiferous tubules found increase of this parameter in the all experimental group in comparison with control. Height of seminiferous epithelium was relatively constant and in all groups but the difference between control and group A was significant (P < 0.05). Analysis of the lumen diameter of seminiferous tubules detected significantly increase mainly group B. Evaluation of the number of cell nuclei per a constant area detected an increase of this parameter in experimental group. Results of this study report a negative effect of cobalt on structure and function of testes.

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Cobalt and its compounds (as inhalable dusts or aerosols) [MAK Value Documentation, 2007]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series MAK Value Documentations , Vol. 23 (2007) The article contains sections titled: Mechanism of Action Toxicokinetics Solubility data Absorption and Distribution Effects in Humans Single exposures Repeated exposures Allergenic effects Animal Experiments and in vitro Studies Allergenic Effects Reproductive toxicity Genotoxicity Carcinogenicity Manifesto (MAK value/classification)

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Metabolic and toxicological studies on cobalt

Cited by 24 publications

References 13 publications

Pathologic Spectrum and Lung Dust Burden in Giant Cell Interstitial Pneumonia (Hard Metal Disease/Cobalt Pneumonitis): Review of 100 Cases

Pathologic Spectrum and Lung Dust Burden in Giant Cell Interstitial Pneumonia (Hard Metal Disease/Cobalt Pneumonitis): Review of 100 Cases

Cobalt-induced alterations in hamster testes in vivo

Cobalt and its compounds (as inhalable dusts or aerosols) [MAK Value Documentation, 2007]

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