Metabolic aspects of the relationship of asthma and obesity

Kytikovа, O. Yu.; Юрьевна, Кытикова Оксана; Аntonyuk, M. V.; Владимировна, Антонюк Марина; Gvozdenko, T. A.; Александровна, Гвозденко Татьяна; Новгородцева, Т. П.; Павловна, Новгородцева Татьяна

doi:10.14341/omet9578

Cited by 20 publications

(7 citation statements)

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“…Известно, что нарушение липидного обмена способствует развитию ожирения, диабета и MС [42,43]. Липидные изменения могут быть как причиной, так и следствием нарушения метаболизма глюкозы, в результате которого развивается резистентность к инсулину.…”

Section: метаболическое фенотипированиеunclassified

“…Соответственно, MС и другие метаболические заболевания и состояния (гипергликемия, дислипидемия, гипертония и сахарный диабет 2 типа), характеризующиеся нарушениями в метаболизме глюкозы или липидов, тесно взаимосвязаны [44]. Однако общая точка зрения на взаимоотношения между MС и другими метаболическими заболеваниями отсутствует [42,45]. Обычная диагностика и лечение этих заболеваний упускает из виду их взаимосвязь и гетерогенность.…”

Section: метаболическое фенотипированиеunclassified

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Prevalence and biomarkers in metabolic syndrome

et al. 2021

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The prevalence of metabolic syndrome (MS) has a worldwide tendency to increase and depends on many components, which explains the complexity of diagnostics and approaches to the prevention and treatment of this pathology. Age, lifestyle, socioeconomic status, insulin resistance (IR), dyslipidemia, obesity and genetic predisposition are factors influencing the risk of developing and progression of MS. Features of the distribution and dysfunction of adipose tissue are important factors in the development of IR, with obesity, as well as the risk of the formation of cardiometabolic diseases and MS. Understanding of mechanisms is linked to advances in metabolic phenotyping. Metabolic phenotyping of obese persons is important for the development of important diseases in relation to the study of the pathophysiology of metabolic disorders, the possible concomitant disease and the search for innovative strategies for the prevention and treatment of MS. The understanding of MS mechanisms is associated with advances in metabolic phenotyping. Therefore, the relevance of further study of the pathophysiological mechanisms underlying various metabolic phenotypes of MS is one of the promising areas of modern scientific research. This review summarizes the current literature data on the prevalence of MS depending on gender, age, population, area of residence, education, level of physical activity, and many other parameters. Metabolic risks of MS development are detailed. Biological markers of MS are considered. The necessity of metabolic phenotyping of MS has been shown, which may have potential therapeutic value.

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Section: метаболическое фенотипированиеunclassified

Prevalence and biomarkers in metabolic syndrome

et al. 2021

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“…В связи с открытием секреторной функции жировой ткани ее метаболические эффекты рассматриваются в фокусе патофизиологической ассоциации с социально значимыми заболеваниями современности, в частности БА и ожирением [12]. Гормоны жировой ткани ответственны за энергетический гомеостаз организма, поэтому избыточное накопление жировой ткани сопровождается развитием дисбаланса метаболических процессов в различных органах и тканях.…”

Section: эпидемиология бронхиальной астмы и ожиренияunclassified

The pathophysiological role of adipokines in the development of bronchial asthma combined with obesity

Kytikovа

Юрьевна²,

Аntonyuk

et al. 2021

Terapevticheskii arkhiv

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The combined course of bronchial asthma (BA) and obesity is one of the urgent medical and social problems that requires a comprehensive and careful study in connection with a decrease in the quality of life of such patients, an increase in the frequency, duration of hospitalization and a high economic burden for the state as a whole. The relationship between BA and obesity is now confirmed by numerous studies, at the same time, despite the variability of the proposed mechanisms of pathogenetic effects of obesity on asthma, metabolic aspects of the relationship of these diseases need further study. Adipose tissue hormones are responsible for the energy homeostasis of the body therefore, excessive accumulation of adipose tissue is accompanied by the development of an imbalance in metabolic processes in various organs and tissues. Due to the emergence of new scientific data on the role and function of adipokines in the body, metabolic effects of adipokines are considered in the focus of their pathophysiological association with obesity and asthma. This literary review highlights the current understanding of the role of metabolic effects of the most studied adipokines (resistin, retinol-binding protein, leptin and adiponectin) in the development of obesity and BA. Gender and age-dependent features of adipokine levels in BA and obesity are described. Data on the confirmed role of adiponectin and leptin in the progression of BA combined with obesity are presented. It has been shown that the role of resistin and retinol-binding protein in the development of BA combined with obesity has not been studied. It is demonstrated that further study of metabolic activity of adipokines in BA is an actual and perspective direction of researches which will allow to develop new diagnostic and therapeutic strategies in patients with BA with obesity.

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“…В связи с пристальным вниманием исследователей к молекулярным механизмам развития заболеваний значительное число научных работ посвящено изучению функционирования мембранных структур клетки, в частности ее липидного компонента, вовлеченного в процессы регуляции важнейших клеточных процессов [25][26][27][28][29][30].…”

Section: толл-подобные рецепторы и липидные рафтыunclassified

The role of lipids in the signaling mechanisms of toll-like receptors

et al. 2020

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Toll-like receptors (TLRs) are important players in innate and adaptive immune responses involved in the initiation of the inflammatory process in response to the stimulating influence of endogenous (аllarmine) and exogenous ligands (pathogens viruses, bacteria, fungi). It has now become apparent that not only viral and bacterial infections but non-infectious inflammatory diseases are accompanied by the activation of inflammatory response systems and the development of chronic inflammation associated with disorders in the regulation of the TLRs system. In this regard, the ligand-independent activation of TLRs, which occurs with the participation of lipids, is actively studied. Their signalling functions of TLRs implemented in unique microdomains does membrane lipid rafts that coordinate many cellular processes. The ability to activate TLRs has been found for saturated fatty acids (SFAs), both exogenous and endogenous. On the other hand, TLRs can be inhibited by omega-3 polyunsaturated fatty acids (PUFAs), which can block the inflammatory process. The activation of TLRs triggers a signal cascade that induces the production of reactive oxygen and nitrogen species. The development of oxidative stress is accompanied by the formation of oxidized forms of phospholipids (Ox-PLs), which also induce the development of chronic inflammation. At the same time, Ox-PLs is characterized not only by pro-inflammatory but also anti-inflammatory activity, which necessitates in-depth studies of their role in the implementation of these processes. This review article discusses the mechanisms by which SFAs, PUFAs, and Ox-PLs modulate TLRs activation in lipid rafts. Research into the details of these mechanisms will contribute to the development of a strategy to reduce the risk of chronic diseases caused by inflammatory reactions mediated by TLRs.

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Metabolic aspects of the relationship of asthma and obesity

Cited by 20 publications

References 43 publications

Prevalence and biomarkers in metabolic syndrome

Prevalence and biomarkers in metabolic syndrome

The pathophysiological role of adipokines in the development of bronchial asthma combined with obesity

The role of lipids in the signaling mechanisms of toll-like receptors

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