Metabolic Aspects of Thyroid-Adrenal Interrelationship

Catecholamine Depletion in Thyrotoxicosis

“…The average cardiac index decreased significantly from a value of 5 In the three patients receiving a lower dose of guanethidine oxygen consumption, cardiac index, brachial arterial pressure, venous pressure and central volume were essentially unchanged from control values after guanethidine administration. Heart rate, and pressure time per minute were decreased followving the drug, whereas stroke volume, ejection Circulation, Volume XXXJ, Februry 1965 time, cardiac work, and mean rate of left ventricular ejection increased.…”

The Effect of Hypophysectomy on the Action of Thyroxine and Adrenaline on the Metabolic Rate of Mice

“…The well-known synergism (Barker, Fazikas & Himwich, 1936;Ring, 1942;Swanson, 1956) between the metabolic actions of thyroxine and adrenaline is demon¬ strated by data summarized in Tables 1 and 3, for very low concentrations of adrena¬ line restored the metabolic effects of thyroxine in adrenalectomized mice. The fact that the metabolic rates of such adrenalectomized animals were found totally refractory to thyroxine (Ganju & Lockett, 1958) may indicate that adrenaline is requisite for, as well as synergistic with, the influence of thyroxine on the oxygen consumption of this species.…”