Metabolic Bone Disease in Children With Transfusion-Dependent Thalassemia

Handattu, Koushik; Aroor, Shrikiran; Kini, Pushpa; Y, Ramesh Bhat; Shivakumar, Gayathri; Shastry, Praveen; Shetty, Sahana

doi:10.1007/s13312-022-2663-6

Cited by 4 publications

(1 citation statement)

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“… 133 A multiple clinical cohort study showed an increased incidence of nontraumatic fractures in patients with thalassemia, and the risk of fractures was associated with the severity of the anemia and frequency of transfusion. 134 , 135 The results of a 19-year retrospective longitudinal study showed that thalassemia patients with iron overload exhibited a significant and sustained decrease in femoral neck and overall bone density, and male patients showed a greater decline in BMD and a higher risk of fracture than female patients. 136 Further mechanistic studies have revealed that increased bone resorption due to ferroptosis is linked to the pathogenesis of thalassemia-associated bone diseases.…”

Section: Ferroptosis In Age-related Orthopedic Diseasesmentioning

confidence: 99%

Fighting age-related orthopedic diseases: focusing on ferroptosis

Xie

et al. 2023

Bone Res

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Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation and lipid peroxidation. It is closely related to multiple biological processes, including iron metabolism, polyunsaturated fatty acid metabolism, and the biosynthesis of compounds with antioxidant activities, including glutathione. In the past 10 years, increasing evidence has indicated a potentially strong relationship between ferroptosis and the onset and progression of age-related orthopedic diseases, such as osteoporosis and osteoarthritis. Therefore, in-depth knowledge of the regulatory mechanisms of ferroptosis in age-related orthopedic diseases may help improve disease treatment and prevention. This review provides an overview of recent research on ferroptosis and its influences on bone and cartilage homeostasis. It begins with a brief overview of systemic iron metabolism and ferroptosis, particularly the potential mechanisms of ferroptosis. It presents a discussion on the role of ferroptosis in age-related orthopedic diseases, including promotion of bone loss and cartilage degradation and the inhibition of osteogenesis. Finally, it focuses on the future of targeting ferroptosis to treat age-related orthopedic diseases with the intention of inspiring further clinical research and the development of therapeutic strategies.

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