Metabolic bone disease of prematurity

Rustico, Stacy; Calabria, Andrew C.; Garber, Samuel J.

doi:10.1016/j.jcte.2014.06.004

Cited by 91 publications

(166 citation statements)

References 41 publications

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“…La forma de asegurar un aporte adecuado para la mineralización ósea es la excreción urinaria de Ca y P, que debe ser > 1,2 mmol/l o > 4,8 mg/dl para el calcio y > 0,4 mmol/l o > 1,2 mg/dl para el fósforo [51][52][53] .…”

Section: Control De Evoluciónunclassified

Nutrición intrahospitalaria del prematuro. Recomendaciones de la Rama de Neonatología de la Sociedad Chilena de Pediatría

Mena

Milad

Vernal

et al. 2016

Revista Chilena de Pediatría

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Recommendations based on current publications are presented for postnatal preterm nutrition, depending on birth weight: less 1000g, between 1000 and 1500g, and above 1500g, as well for the development periods: adaptation, stabilisation, and growth. A review is also presented on the nutritional management of morbidities that affect or may affect nutrition, such as: osteopenia, bronchopulmonary dysplasia, patent ductus arteriosus, red cell transfusion, and short bowel syndrome.

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Section: Control De Evoluciónunclassified

Nutrición intrahospitalaria del prematuro. Recomendaciones de la Rama de Neonatología de la Sociedad Chilena de Pediatría

Mena

Milad

Vernal

et al. 2016

Revista Chilena de Pediatría

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“…One of the adverse outcomes of prematurity is osteopenia of prematurity and one of the risk factors for this condition is vitamin D deficiency. [3] Based on recent studies, a significant percentage of the general population suffers from vitamin D deficiency. The overall prevalence of vitamin D deficiency has been estimated at 41.6% in several studies, with the highest rate reported among black people (82.1%).…”

Section: Introductionmentioning

confidence: 99%

A Study of Vitamin D Level in Newborn with Special Reference to Correlation with Gestational Age, Morbidity and Maternal Vitamin D Level

Shah¹,

Gosai²,

Ladumor³

2017

AIMDR

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Background: Recently the high prevalence of vitamin D level deficiency in general population. Pregnancy and preterm deliveries are known as risk Factors for vitamin d deficiency.. In the study we aimed to compare vitamin D level in term and preterm newborn mother pair. Methods: We prospectively collected vitamin D blood level in term and preterm newborn with their mother's vitamin D level in neonatal ICU at tertiary health care centre. Results: Total 80 newborn mother pair was recruited in study, including 44 preterm (55%) and 36 term (45%) newborns In total 41.9% and 55.9% of preterm and term newborn had vitamin D deficiency, respectively and 47.6% & 32.5% of preterm and term newborn had vitamin D insufficiency, respectively. Among all newborns, 48.9% had vitamin D deficiency, although the difference between term and preterm newborn was not statistically significant. Based on findings, serum vitamin D levels in mother and newborns were significantly correlated (p<0.001). The Data suggest that preterm & term newborn with vitamin D deficiency have higher incidence of ROP & sepsis respectively as compared to others (p<0.001). Conclusion: According to present study, vitamin D level in mother and newborn were significantly correlated and vitamin D level deficiency in preterm and term newborn is associated with higher chances of development of ROP and early onset septicemia respectively, there is no significant correlation between gestational age and vitamin D level in newborn mother pair.

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“…Osteopenia, commonly known as metabolic bone disease (MBD), can be due to decreased bone mineralization or increased bone resorption [1]. Babies born prematurely (< 37th weeks of gestation or even <28th week of gestation), with very low birth weight (VLBW, <1500grams) and extremely low birth weight (ELBW, <1000grams) are at increased risk of developing the condition, called as osteopenia of prematurity [2]. This condition has drawn interest of many neonatologistsbecause of its increasing incidence over last few decades.…”

Section: Introductionmentioning

confidence: 99%

“…Accumulating inversely associated with gestational age and body weight [1,4,5,6]. Most commonly, osteopenia occurs as a result of reduced transplacental mineral delivery in preterm, poor nutritional intake and excessive mineral loss after birth [2,4]. The etiology of MBD is multifactorial which includes degree of prematurity, low birth weight, exposure to medications that can alter mineral levels, immobilization, lack of mechanical stimulation, long term parenteral nutrition, delayed establishment of full feedand inadequate nutrients intake.…”

Section: Introductionmentioning

confidence: 99%

“…The etiology of MBD is multifactorial which includes degree of prematurity, low birth weight, exposure to medications that can alter mineral levels, immobilization, lack of mechanical stimulation, long term parenteral nutrition, delayed establishment of full feedand inadequate nutrients intake. [2,6,7]. This condition can remain silent or can lead to serious complications, which makes the preterm newborn more susceptible to rachitic changes and/or fracturesduring minimal invasive procedures and even with routine handling in neonatal intensive care units [8].…”

Section: Introductionmentioning

confidence: 99%

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Osteopenia of prematurity: Assessment of Biochemical parameters in Very low birth weight preterm neonates

2016

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Background: Osteopenia of prematurity, commonly called as metabolic bone disease (MBD), is mostly described in preterm babies (< 36weeks) with very low birth weight (VLBW). This condition is characterized by a reduction in bone mineral content (osteopenia), with or without rachitic changes, and is caused by several nutritional and biomechanical factors. Objective: To determine the incidence of osteopenia of prematurity among high risk preterm VLBW babies and also to document changes in biochemical parameters including serum calcium, serum phosphate, serum alkaline phosphate (ALP) and serum creatinine in the above cases. Material and method: This prospective observational study includes all the very low birth weight babies born fromNovember 2012 to July 2014. Present study comprised of 60 VLBW neonates of which 10 were <28weeks, 32 were 28-31week and 18 were 31-34weeks of gestation. Estimations of biochemical parameters were done at 2 nd week of birth and again at 6 th week to detect the incidence of osteopenia. Result: There was a significant decrease inserum calcium and serum phosphorous level where asserum ALP documented a significant increase in preterm neonates when compared to control. 14 of 60 VLBW babies developed osteopenia of prematurity at 6 th week of life. Conclusion: As observed in the present study, gestational age, birth weight and ALP are considered to be significant risk factors and are associated with osteopenia. So early detection of this condition by monitoring of biochemical parameters in high-risk cases minimizes the development of osteopeniaand prevent future complications of osteopenia.

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Metabolic bone disease of prematurity

Cited by 91 publications

References 41 publications

Nutrición intrahospitalaria del prematuro. Recomendaciones de la Rama de Neonatología de la Sociedad Chilena de Pediatría

Nutrición intrahospitalaria del prematuro. Recomendaciones de la Rama de Neonatología de la Sociedad Chilena de Pediatría

A Study of Vitamin D Level in Newborn with Special Reference to Correlation with Gestational Age, Morbidity and Maternal Vitamin D Level

Osteopenia of prematurity: Assessment of Biochemical parameters in Very low birth weight preterm neonates

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