Metabolic, cellular and defense responses to single and co-exposure to carbamazepine and methylmercury in Dreissena polymorpha

Bioaccumulation and molecular effects of carbamazepine and methylmercury co-exposure in males of Dreissena polymorpha

“…In the context of environmental contamination, biomonitoring aims to assess environmental health to protect biota and linked ecosystem services. The zebra mussel Dreissena polymorpha (Pallas, 1771) is promising for freshwater biomonitoring and ecotoxicological studies (Kerambrun et al, 2016;Klimova et al, 2017;Louis et al, 2019Louis et al, , 2020Hani et al, 2021;Baratange et al, 2022). This species is widely distributed, abundant, and sessile.…”

“…The mode of action of CBZ in vertebrates was suspected to target ion channels (Ambrósio et al, 2002). In bivalves, CBZ exposure triggered oxidative stress, defense responses and altered the energy metabolism at 1-10 µg L -1 range (Chen et al, 2014;Almeida et al, 2015;Baratange et al, 2022;Dumas et al, 2022b, Baali and.…”

“…In vertebrates, MeHg exposure resulted in alterations of the nervous system and cytoskeleton (Yadetie et al, 2016;Pierozan et al, 2017). In gills of D. polymorpha, exposure to 280 ng L -1 MeHg 7d caused antioxidant responses and cellular damages (Baratange et al, 2022).…”

“…Both alter similar molecular toxicity pathways in biota. Their co-exposure in D. polymorpha caused more effects than single exposures (Todgham and Stillman, 2013;Baratange et al, 2022). Besides, effects observed in the co-exposure were unpredictable based on the bioaccumulation and effects caused by single exposures (Baratange et al, 2022).…”

“…Their co-exposure in D. polymorpha caused more effects than single exposures (Todgham and Stillman, 2013;Baratange et al, 2022). Besides, effects observed in the co-exposure were unpredictable based on the bioaccumulation and effects caused by single exposures (Baratange et al, 2022). In this context, a better insight into the molecular toxicity pathways of CBZ and Hg in single and co-exposures is needed for a better anticipation of adverse effects in complex exposure scenarios.…”