Metabolic Changes in Sepsis and Septic Shock

Watters, James M.; Wilmore, Douglas W.

doi:10.1007/978-3-642-83083-9_29

Sepsis 1989

DOI: 10.1007/978-3-642-83083-9_29

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Metabolic Changes in Sepsis and Septic Shock

James M. Watters¹,

Douglas W. Wilmore²

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1996

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Augmentations of glucose uptake and glucose transporter-1 in macrophages following thermal injury and sepsis in mice

Gamelli

Hong

et al. 1996

Journal of Leukocyte Biology

143

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Glucose is the primary metabolic substrate of macrophages, which are critical components of the host response to injury and infection. We have carried out a series of studies to examine macrophage glucose uptake and the status of glucose transporter 1 (GLUT1) at both the mRNA and protein level. Peritoneal macrophages that were obtained from mice undergoing sham burned (S), 15%TBSA burn (B) +/- Pseudomonas aeruginosa burn infection (B + I) and lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF-alpha) administration. [3H]deoxyglucose uptake was significantly increased (B, 157 +/- 9%; B + I, 243 +/- 19%; S + LPS, 231 +/- 24%; S + TNF-alpha, 379 +/- 18%; B + LPS, 230 +/- 13%; and B + TNF, 305 +/- 23%, P< 0.01 vs. sham). GLUT1 mRNA and protein levels were increased as well (mRNA: B, 135 +/- 13%; B + I, 250 +/- 33%; S + LPS, 282 +/- 29%; S + TNF-alpha, 193 +/- 19%; B + LPS, 378 +/- 20%; and B + TNF-alpha, 204 +/- 16%; protein: B, 159 +/- 27%; B + I, 181 +/- 17%; S + LPS, 219 +/- 26%; S + TNF-alpha, 343 +/- 51%; B + LPS, 366 +/- 41%; and B + TNF-alpha, 415 +/- 44, P< 0.01 vs. sham). Macrophages co-cultured with LPS or TNF-alpha in vitro demonstrated a similar response pattern. Following burn injury and infection, macrophages augment their cellular glucose uptake, which is facilitated by an increased GLUT1 mRNA and protein levels. TNF-alpha elicited by LPS may mediate this enhanced carbohydrate metabolism at the point of glucose entry into the cell.

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Augmentations of glucose uptake and glucose transporter-1 in macrophages following thermal injury and sepsis in mice

Gamelli

Hong

et al. 1996

Journal of Leukocyte Biology

143

View full text Add to dashboard Cite

show abstract

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Metabolic Changes in Sepsis and Septic Shock

Cited by 1 publication

References 86 publications

Augmentations of glucose uptake and glucose transporter-1 in macrophages following thermal injury and sepsis in mice

Augmentations of glucose uptake and glucose transporter-1 in macrophages following thermal injury and sepsis in mice

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