Metabolic Connectivity as Index of Verbal Working Memory

Zou, Na; Chételat, Gaël; Baydoğan, Mustafa Gökçe; Li, Jing; Fischer, Florian; Titov, Dmitry; Dukart, Juergen; Fellgiebel, Andreas; Schreckenberger, Mathias; Yakushev, Igor

doi:10.1038/jcbfm.2015.40

Cited by 18 publications

(23 citation statements)

References 32 publications

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“…We used partial correlation‐based connectivity estimation using the sparse inverse covariance estimation to construct the metabolic networks. To determine the optimal sparsity control parameter, a stability approach to regularization selection was utilized . The advantage of sparse inverse covariance estimation is that it renders zero for very weak connectivity, making the network sparse, and does not need a threshold for network analysis.…”

Section: Methodsmentioning

confidence: 99%

Interregional metabolic connectivity of 2‐deoxy‐2[¹⁸F]fluoro‐D‐glucose positron emission tomography in vagus nerve stimulation for pediatric patients with epilepsy: A retrospective cross‐sectional study

Cho

et al. 2018

Epilepsia

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Objective: With the recognition of epilepsy as a network disease that disrupts the organizing ability of resting-state brain networks, vagus nerve stimulation (VNS) may control epileptic seizures through modulation of functional connectivity. We evaluated preoperative 2-deoxy-2[ 18 F]fluoro-D-glucose (FDG) positron emission tomography (PET) in VNS-implanted pediatric patients with refractory epilepsy to analyze the metabolic connectivity of patients and its prognostic role in seizure control. Methods: Preoperative PET data of 66 VNS pediatric patients who were followed up for a minimum of 1 year after the procedure were collected for the study. Retrospective review of the patients' charts was performed, and five patients with inappropriate PET data or major health issues were excluded. We conducted an independent component analysis of FDG-PET to extract spatial metabolic components and their activities, which were used to perform cross-sectional metabolic network analysis. We divided the patients into VNS-effective and VNS-ineffective groups (VNS-effective group, ≥50% seizure reduction; VNS-ineffective group, <50% reduction) and compared metabolic connectivity differences between groups using a permutation test. Results: Thirty-four (55.7%) patients showed >50% seizure reduction from baseline frequency 1 year after VNS. A significant difference in metabolic connectivity evaluated by preoperative FDG-PET was noted between groups. Relative changes in glucose metabolism were strongly connected among the areas of brainstem, cingulate gyrus, cerebellum, bilateral insula, and putamen in patients with <50% seizure control after VNS. Significance: This study shows that seizure outcome of VNS may be influenced by metabolic connectivity, which can be obtained from preoperative PET imaging. This study of metabolic connectivity analysis may contribute in further understanding of the mechanism of VNS in intractable seizures. K E Y W O R D S 2-deoxy-2[ 18 F]fluoro-D-glucose (FDG) PET, epilepsy, metabolic connectivity, vagus nerve stimulation

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Section: Methodsmentioning

confidence: 99%

Interregional metabolic connectivity of 2‐deoxy‐2[¹⁸F]fluoro‐D‐glucose positron emission tomography in vagus nerve stimulation for pediatric patients with epilepsy: A retrospective cross‐sectional study

Cho

et al. 2018

Epilepsia

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“…The regularization parameter λ was determined using Stability Approach to Regularization Selection ( 32 ). Since edges generally shrink after gLASSO, we adjusted the edges to reflect connectivity strength properly ( 33 ) using a sample covariance matrix and a sparse structure of original precision matrix ( 34 ). Functional networks were constructed by thresholding pFC > 10 −5 , since gLASSO shrinks unrelated edges to 0.…”

Section: Methodsmentioning

confidence: 99%

Immediate and Longitudinal Alterations of Functional Networks after Thalamotomy in Essential Tremor

et al. 2016

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Thalamotomy at the ventralis intermedius nucleus has been an effective treatment method for essential tremor, but how the brain network changes immediately responding to this deliberate lesion and then reorganizes afterwards are not clear. Taking advantage of a non-cranium-opening MRI-guided focused ultrasound ablation technique, we investigated functional network changes due to a focal lesion. To classify the diverse time courses of those network changes with respect to symptom-related long-lasting treatment effects and symptom-unrelated transient effects, we applied graph-theoretic analyses to longitudinal resting-state functional magnetic resonance imaging data before and 1 day, 7 days, and 3 months after thalamotomy with essential tremor. We found reduced average connections among the motor-related areas, reduced connectivity between substantia nigra and external globus pallidum and reduced total connection in the thalamus after thalamotomy, which are all associated with clinical rating scales. The average connectivity among whole brain regions and inter-hemispheric network asymmetry show symptom-unrelated transient increases, indicating temporary reconfiguration of the whole brain network. In summary, thalamotomy regulates interactions over the motor network via symptom-related connectivity changes but accompanies transient, symptom-unrelated diaschisis in the global brain network. This study suggests the significance of longitudinal network analysis, combined with minimal-invasive treatment techniques, in understanding time-dependent diaschisis in the brain network due to a focal lesion.

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“…In analogy with previous studies, 11,22 the data were assumed to follow a multivariate Gaussian distribution. That is, x 1 , .…”

Section: Metabolic Connectivity Patternmentioning

confidence: 99%

Metabolic connectivity for differential diagnosis of dementing disorders

Titov

Diehl‐Schmid

Shi

et al. 2016

J Cereb Blood Flow Metab

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Presently, visual and quantitative approaches for image-supported diagnosis of dementing disorders rely on regional intensity rather than on connectivity measurements. Here, we test metabolic connectivity for differentiation between Alzheimer's disease and frontotemporal lobar degeneration. Positron emission tomography with 18F-fluorodeoxyglucose was conducted in 47 patients with mild Alzheimer's disease, 52 patients with mild frontotemporal lobar degeneration, and 45 healthy elderly subjects. Sparse inverse covariance estimation and selection were used to identify patterns of metabolic, inter-subject covariance on the basis of 60 regional values. Relative to healthy subjects, significantly more pathological within-lobe connections were found in the parietal lobe of patients with Alzheimer's disease, and in the frontal and temporal lobes of subjects with frontotemporal lobar degeneration. Relative to the frontotemporal lobar degeneration group, more pathological connections between the parietal and temporal lobe were found in the Alzheimer's disease group. The obtained connectivity patterns differentiated between two patients groups with an overall accuracy of 83%. Linear discriminant analysis and univariate methods provided an accuracy of 74% and 69%, respectively. There are characteristic patterns of abnormal metabolic connectivity in mild Alzheimer's disease and frontotemporal lobar degeneration. Such patterns can be utilized for single-subject analyses and might be more accurate in the differential diagnosis of dementing disorders than traditional intensity-based analyses.

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Metabolic Connectivity as Index of Verbal Working Memory

Cited by 18 publications

References 32 publications

Interregional metabolic connectivity of 2‐deoxy‐2[¹⁸F]fluoro‐D‐glucose positron emission tomography in vagus nerve stimulation for pediatric patients with epilepsy: A retrospective cross‐sectional study

Interregional metabolic connectivity of 2‐deoxy‐2[¹⁸F]fluoro‐D‐glucose positron emission tomography in vagus nerve stimulation for pediatric patients with epilepsy: A retrospective cross‐sectional study

Immediate and Longitudinal Alterations of Functional Networks after Thalamotomy in Essential Tremor

Metabolic connectivity for differential diagnosis of dementing disorders

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Metabolic Connectivity as Index of Verbal Working Memory

Cited by 18 publications

References 32 publications

Interregional metabolic connectivity of 2‐deoxy‐2[18F]fluoro‐D‐glucose positron emission tomography in vagus nerve stimulation for pediatric patients with epilepsy: A retrospective cross‐sectional study

Interregional metabolic connectivity of 2‐deoxy‐2[18F]fluoro‐D‐glucose positron emission tomography in vagus nerve stimulation for pediatric patients with epilepsy: A retrospective cross‐sectional study

Immediate and Longitudinal Alterations of Functional Networks after Thalamotomy in Essential Tremor

Metabolic connectivity for differential diagnosis of dementing disorders

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Interregional metabolic connectivity of 2‐deoxy‐2[¹⁸F]fluoro‐D‐glucose positron emission tomography in vagus nerve stimulation for pediatric patients with epilepsy: A retrospective cross‐sectional study

Interregional metabolic connectivity of 2‐deoxy‐2[¹⁸F]fluoro‐D‐glucose positron emission tomography in vagus nerve stimulation for pediatric patients with epilepsy: A retrospective cross‐sectional study