Metabolic Consequences of Obesity and Body Fat Pattern: Lessons from Migrant Studies

McKeigue, Paul M.

doi:10.1002/9780470514962.ch4

Cited by 29 publications

(20 citation statements)

References 43 publications

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“…It may elevate triglyceride and lower HDL. (31.8% vs 8%) (McKeigue 1996) in this study. 37.9% had higher waist circumference, 54.3% had higher TG and 69.8% had decreased HDL which is much higher than normal population.…”

Section: Discussionsupporting

confidence: 41%

Age and Gender Differences of Metabolic Factors among the Essential Hypertension Patients at a Tertiary Care Hospital in Dhaka

Akhtaruzzaman

Khandaker

Banu³

et al. 2016

J Sci Found

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Background: Metabolic syndrome is a risk factor for cardiovascular disease. Objectives: The purpose of the present study was to see the association of metabolic syndrome with essential hypertension. Methodology: This cross sectional study was carried out in the OPD of the Department of Cardiology at Shaheed Suhrawardy Medical college Hospital, Dhaka from January 2008 to December 2010. All the All the Metabolic syndrome was defined as abnormal fasting serum level of glucose (≥ 110 mg/dl or 6.1 mmol/L) with abdominal obesity (waist circumference > 102 cm in men and > 88cm in women), triglycerides (≥ 150mg/dl), High density lipoprotein cholesterol (< 40 mg/dl in men and < 50 mg/dl in women) and hypertension. Results: . A total of 322 patients were enrolled Among hypertensive patients 31.8% had hyperglycemia, 37.9% had high waist circumference, 69.8% had low HDL cholesterol and 54.3% high triglycerides. As per definition of NCEP-ATP-III, metabolic syndrome had been detected in 17% of male, 37% of female and 27% of total population. Conclusion: Metabolic factors are a common association in hypertensive cases. These patients are at increased risk of coronary and cerebro-vascular disease and require more vigorous prevention. Furthermore in all hypertensive patients metabolic screening is recommended.

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Section: Discussionsupporting

confidence: 41%

Age and Gender Differences of Metabolic Factors among the Essential Hypertension Patients at a Tertiary Care Hospital in Dhaka

Akhtaruzzaman

Khandaker

Banu³

et al. 2016

J Sci Found

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“…We extended this previous observation in a much younger patient population and demonstrated that Indians have a 3-fold risk of developing premature AMI in comparison to the other ethnic groups. Prior studies [18][19][20][21][22] have shown that Indians have at least double the risk of CAD than than of white patients after adjustment of risk factors. The causes of this ethnic predisposition to CAD are likely to be multi-factorial ie interaction between genetic and environmental factors.…”

Section: Discussionmentioning

confidence: 99%

Acute myocardial infarction: Clinical features and outcomes in young adults in Singapore

Wong

Loh²,

Loh³

et al. 2012

WJC

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AIM:To investigate the clinical features and in-hospital outcomes of young adults with acute myocardial infarction (AMI) in Singapore. METHODS:Between January 2005 to September 2010, 333 consecutive patients aged ≤ 45 years old were diagnosed to have AMI at our institution. As Singapore is a multi-ethnic society, we also analysed whether ethnic differences exist between the three dominant ethnic groups, Malay, Chinese and Indian with regards to the clinical features. Clinical data was collected retrospectively on demographic characteristics, presenting signs and symptoms, blood investigation, angiographic findings and in-hospital clinical outcomes. RESULTS:The mean age at presentation was 40.2 ± 4.0 years with male predominance (94%). The majority of patients were Chinese (51%) followed by Indians (31%) and Malays (18%). The most common risk factor was smoking (74%) followed by hypertension (28.5%) and hyperlipidemia (20.0%). 37% of patients were obese. The majority of patients had single vessel disease (46%) on coronary angiography. The mean total cholesterol, low-density lipoprotein and highdensity lipoprotein levels were 5.6 ± 1.2 mmol/L, 3.8 ± 1.1 mmol/L and 0.93 ± 0.25 mmol/L respectively. The mean left ventricular function was 44% ± 10% with the incidence of heart failure 3% and cardiogenic shock 4.5%. Overall in-hospital mortality was low with 4 deaths (1.2%). For ethnic subgroup analysis, Indians have a 3-fold risk of developing premature AMI when compared to other ethnic groups. CONCLUSION:Young AMI patients in Singapore are characterized by male predominance, high incidence of smoking and obesity. Overall in-hospital clinical outcomes are favourable. Among the 3 ethnic groups, Indians have the highest risk of developing premature AMI.

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“…36,37 Yet the prevalence of CVD in South Asians increases after migration to developed countries, an increase that has been attributed to the adverse consequences of adopting a 'Westernized' diet and lifestyle. [38][39][40][41] Meanwhile, a shift from rural to increasingly urban lifestyles has contributed to the CVD epidemic in India. 36 For the MetS to be effective as a predictive tool, it must be able to account accurately for the changes in individuals and populations that confer increased CVD risk.…”

Section: Clinical Use Of the Mets As A Predictor Of Cvd And T2dmmentioning

confidence: 99%

Does using ethnic specific criteria improve the usefulness of the term metabolic syndrome? controversies and suggestions

Banerjee

Misra

2007

Int J Obes

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The metabolic syndrome (MetS) is an important tool that identifies populations at increased risk for cardiovascular disease (CVD) and type 2 diabetes, targeting them for preventive measures. The criteria for the identification of the MetS were initially constructed from data in Caucasian populations. Recent research suggests that the current criteria for the MetS may not accurately characterize disease risk in non-Caucasian populations, either over or underestimating the risk in certain ethnic groups. Altering the criteria for each population by making ethnic-specific cutoffs as has been done with waist circumference will help in more accurate characterization. Using different combinations of the MetS criteria for different ethnic groups based CVD risk and factor analysis needs consideration. With better characterizations of patient populations, the ultimate goal would be to make MetS more accurate for predicting CVD risk while retaining the ease of screening afforded by the MetS. The proposed alterations of definition and criteria of the MetS would ensure its continued viability and sustainability.

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Metabolic Consequences of Obesity and Body Fat Pattern: Lessons from Migrant Studies

Cited by 29 publications

References 43 publications

Age and Gender Differences of Metabolic Factors among the Essential Hypertension Patients at a Tertiary Care Hospital in Dhaka

Age and Gender Differences of Metabolic Factors among the Essential Hypertension Patients at a Tertiary Care Hospital in Dhaka

Acute myocardial infarction: Clinical features and outcomes in young adults in Singapore

Does using ethnic specific criteria improve the usefulness of the term metabolic syndrome? controversies and suggestions

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