2024
DOI: 10.3390/ijms25147880
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Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies

Adriana Fontes,
Adrian T. Jauch,
Judith Sailer
et al.

Abstract: Essential transition metals have key roles in oxygen transport, neurotransmitter synthesis, nucleic acid repair, cellular structure maintenance and stability, oxidative phosphorylation, and metabolism. The balance between metal deficiency and excess is typically ensured by several extracellular and intracellular mechanisms involved in uptake, distribution, and excretion. However, provoked by either intrinsic or extrinsic factors, excess iron, zinc, copper, or manganese can lead to cellular damage upon chronic … Show more

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