Metabolic detoxification of the phytoalexins maackiain and medicarpin by Nectria haematococca field isolates: relationship to virulence on chickpea

Lucy, M.C.; Matthews, Patty S.; VanEtten, Hans D.

doi:10.1016/0885-5765(88)90019-7

Cited by 35 publications

(19 citation statements)

References 18 publications

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“…The phytoalexins (-)maackiain and (-)medicarpin are produced by chickpea (Cicer arietinum L.) in response to pathogens. Some FSSC 11 isolates are highly virulent on chickpea and are tolerant to phytoalexins; conversely, isolates more sensitive to maackiain are less virulent on this host plant (Lucy et al, 1988). Isolates of FSSC 11 were able to perform three metabolic modifications on maackiain and medicarpin via monooxygenases and were able to detoxify the phytoalexins to the less inhibitory (-)-6a-hydroxypterocarpan, the 1a-hydroxydienone and the isoflavanone derivatives VanEtten, 1981, 1982;Lucy et al, 1988).…”

Section: Tolerance To Plant Defence Mechanismsmentioning

confidence: 99%

The Fusarium solani species complex: ubiquitous pathogens of agricultural importance

Coleman

2015

Molecular Plant Pathology

181

104

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Section: Tolerance To Plant Defence Mechanismsmentioning

confidence: 99%

The Fusarium solani species complex: ubiquitous pathogens of agricultural importance

Coleman

2015

Molecular Plant Pathology

181

104

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“…MeJA is involved in signaling in wound responses, such as those that occur during insect herbivory (McConn et al, 1997;Baldwin, 1998), and medicarpin is a well-known antimicrobial phytoalexin (Lucy et al, 1988;Blount et al, 1992). With the provision that these studies were conducted using an artificial cell culture system, the marked coordinated increases in medicarpin and afrormosin levels in response to MeJA suggest that these compounds might have dual defensive roles against both insects and fungi.…”

Section: Functions For Induced Isoflavonoids In Medicagomentioning

confidence: 99%

Metabolomics Reveals Novel Pathways and Differential Mechanistic and Elicitor-Specific Responses in Phenylpropanoid and Isoflavonoid Biosynthesis in Medicago truncatula Cell Cultures

et al. 2007

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High-performance liquid chromatography coupled to ultraviolet photodiode array detection and ion-trap mass spectrometry was used to analyze the intra-and extracellular secondary product metabolome of Medicago truncatula cell suspension cultures responding to yeast elicitor (YE) or methyl jasmonate (MeJA). Data analysis revealed three phases of intracellular response to YE: a transient response in mainly (iso)flavonoid metabolites such as formononetin and biochanin-A that peaked at 12 to 18 h following elicitation and then declined; a sustained response through 48 h for compounds such as medicarpin and daidzin; and a lesser delayed and protracted response starting at 24 h postelicitation, e.g. genistein diglucoside. In contrast, most compounds excreted to the culture medium reached maximum levels at 6 to 12 h postelicitation and returned to basal levels by 24 h. The response to MeJA differed significantly from that to YE. Although both resulted in accumulation of the phytoalexin medicarpin, coordinated increases in isoflavonoid precursors were only observed for YE and not MeJA-treated cells. However, MeJA treatment resulted in a correlated decline in isoflavone glucosides, and did not induce the secretion of metabolites into the culture medium. Three novel methylated isoflavones, 7-hydroxy-6,4#-dimethoxyisoflavone (afrormosin), 6-hydroxy-7,4#-dimethoxyisoflavone (alfalone), and 5,7-dihydroxy-4#,6-dimethoxy isoflavone (irisolidone), were induced by YE, and labeling studies indicated that the first two were derived from formononetin. Our results highlight the metabolic flexibility within the isoflavonoid pathway, suggest new pathways for complex isoflavonoid metabolism, and indicate differential mechanisms for medicarpin biosynthesis depending on the nature of elicitation.

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“…Similarly, the virulence of A'. haematococca isolates on chickpea (Lucy, Matthews & VanEtten, 1988;Miao & VanEtten, 19926) correlates with their ability to detoxify maackiain and medicarpin (Mak""). The virulence of F. solani f. sp.…”

Section: Phytoalexin Detoxificationmentioning

confidence: 99%

Tansley Review No. 86 Accumulation of phytoalexins: defence mechanism and stimulus response system

Smith

1996

New Phytologist

214

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SUMMARY Phytoalexin synthesis is a defence‐response‐ that is characterized by a requirement for a number of distinct elements, all of which must be present for the response to be expressed fully. These same elements: a signal, a cellular receptor, a signal transduction system and a responsive metabolic system, are also used to describe a stimulus‐response system. A number of molecular species can function as signal molecules or elicitors of phytoalexin synthesis, including poly‐ and oligosaccharides, proteins and polypeptides, and fatty acids. Few receptors for elicitors have been identified but those that have been are proteins located on the plasma membrane of the plant. Induction of phytoalexin synthesis involves selective and co‐ordinated activation of specific defence response genes, including those encoding the enzymes of phytoalexin synthesis, and these genes constitute the responsive metabolic system. The separate, and distant, locations of the receptor and the responsive genes means that the event in which the signal is perceived by the receptor must be relayed to the genes by means of a second messenger system. Several second messengers are candidates for such a coupling‐ or signal transduction‐system, including udenosine‐3′,5′‐cyclic monophosphate, Ca2+, diacylglycerol and inositol 1,4,5‐trisphosphate, active oxygen species and jasmonic acid. Each has been examined as a possible component of the signal transduction system mediating between the elicitor receptor interaction and the phytoalexin synthesis it induces. Analysis of the signalling events is made complex by the simultaneous solicitation by the invading micro‐organism of several defence responses, each of which might involve elements of a different signal system. The same complexity is evident which the role of phytoalexin accumulation in resistance is analysed. Evaluation of the contribution made by phytoalexin accumulation towards resistance has been attempted by the use of various inhibitors and enhancers of the process. Transgenic and mutant plants with specific alterations in one or more ot those elements necessary for the plant to respond to the signals for phytoalexin synthesis and other defence responses, are beginning to aid resolution of the complex pattern ot signalling events and the respective roles of the inducible defence mechanisms in resistance.

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Metabolic detoxification of the phytoalexins maackiain and medicarpin by Nectria haematococca field isolates: relationship to virulence on chickpea

Cited by 35 publications

References 18 publications

The Fusarium solani species complex: ubiquitous pathogens of agricultural importance

The Fusarium solani species complex: ubiquitous pathogens of agricultural importance

Metabolomics Reveals Novel Pathways and Differential Mechanistic and Elicitor-Specific Responses in Phenylpropanoid and Isoflavonoid Biosynthesis in Medicago truncatula Cell Cultures

Tansley Review No. 86 Accumulation of phytoalexins: defence mechanism and stimulus response system

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