Metabolic disorder induces fatty liver in Japanese seabass, Lateolabrax japonicas fed a full plant protein diet and regulated by cAMP-JNK/NF-kB-caspase signal pathway

Zhang, Y.; Chen, Pei; Liang, Xiaofang; Han, Juan; Wu, Xiangli; Yang, Yuhong; Xue, Mei

doi:10.1016/j.fsi.2019.04.060

Cited by 74 publications

(49 citation statements)

References 53 publications

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“…It is suggested that Chinese perch fed with low level of rapeseed meal diet promoted FA synthesis, and inhibited lipid uptake in liver tissue. Similar results were found in Japanese seabass [38]. It is suggested that the reduction in fat accumulation caused by low level of rapeseed meal did not occur in the liver mainly.…”

Section: Discussionsupporting

confidence: 84%

“…The effect of plant protein on blood glucose in fish depends on fish species, the source and level of plant protein [37]. Japanese seabass fed with a full plant protein diet decreased blood glucose level [38]. However, there was no significant difference in blood glucose of Trachinotus carolinus fed with soybean meal diet was observed [37,39].…”

Section: Discussionmentioning

confidence: 98%

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Adaptation of AMPK-mTOR-signal pathways and lipid metabolism in response to low- and high-rapeseed meal diet in Chinese perch (Siniperca chuatsi)

Liang

Alam

et al. 2020

Preprint

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Background: Chinese perch, a carnivorous fish, can accept artificial diet after domestication nowadays, and this farm way will gain high economic interest and sustainability. However, the high content and high quality requirement of dietary protein make it need the high cost in Chinese perch. Therefore, the aim of this study was to explore the effect of fish meal replacement by low- or high-rapeseed meal on growth performance, feeding, lipid and glucose metabolism. Methods: Three experimental diets were formulated with 0, 10% and 30% rapeseed meal, named as control, RSL and RSH, groups respectively. After the 8-week of feeding trial, growth performance, lipid metabolism and AMPK-mTOR-signal pathways were measured. Results: Chinese perch fed with RSH and RSL diets showed significantly decreased WG, SGR, BFR, VSI, MSI and the whole-body crude lipid compared to those fed with the control diet (P < 0.05). Fish in RSL group decreased feed intake, serum LDL-C, hepatic mRNA expression of LPL, PEPCK and phosphorylated Grb10 (P < 0.05). In visceral adipose tissue, mRNA expression of FAS, SREBP1, ACC1, HL, CPT1 and PEPCK were all significantly down-regulated (P < 0.05). Fish in RSH group showed phosphorylated AMPK, hepatic mRNA expression of SREBP1, ACC1, FAS, PPARα and CPT1 were down-regulated, while HSL, G6PD and PC were up-regulated (P < 0.05). In visceral adipose tissue, mRNA expressions of SREBP1, LPL, CPT1 and PEPCK were down-regulated, while mRNA expression of HSL was up-regulated (P < 0.05). Conclusions: Chinese perch fed with RSL and RSH diets showed decreased fat deposition in viscera. Fish fed with low level of rapeseed meal diet ate less diet, which caused inhibited lipid metabolism in the liver and visceral adipose tissues.Fish fed with high level of rapeseed meal diet inhibited hepatic FA synthesis, activated lipolysis, hence reducing Acetyl-CoA pool. In turn, β-oxidation were inhibited, glycolysis was activated, thus lipid accumulation was decreased. In visceral adipose tissue, lipid uptake was inhibited, caused inhibited FA synthesis, β-oxidation, glycerol synthesis, and improved lipolysis.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 98%

Adaptation of AMPK-mTOR-signal pathways and lipid metabolism in response to low- and high-rapeseed meal diet in Chinese perch (Siniperca chuatsi)

Liang

Alam

et al. 2020

Preprint

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“…Water solubility is a common index of pellet stability (water stability = 1 − water solubility, lower solubility can improve feed intake and reduce water pollution), whereas hydration time reflects the rate of water diffusion inside a pellet. According to previous studies, the feed that was difficult to be softened and saturated with water could slow down the gastric emptying rate and indirectly reduced digestion rate and nutrients absorption (Liang et al, 2016;Zhang et al, 2019). As shown in Figures 5 and 6, the water solubility of the feed pellets decreased with screw speed (p <.05) but increased with the moisture content (p <.01).…”

Section: Water Solubility and Hydration Time Of Pelletmentioning

confidence: 83%

Optimization of the process parameters for extruded commercial sinking fish feed with mixed plant protein sources

Wang

Yang

et al. 2020

J Food Process Engineering

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The aim of the investigation was to optimize extrusion process parameters for processing commercial sinking fish feed with mixed plant protein sources in a pilot‐scale twin‐screw extruder equipped with a preconditioner. It has been found out that the bulk density of feed pellets increased with the moisture content in the range of 22–27% (wt), then decreased with the moisture content from 27 to 32%. Meanwhile, increasing moisture content (22–32%) resulted in a decrease of pellet hardness, water solubility, and specific mechanical energy (SME), and an increase of pellet hydration time. There was a significant decrease (p <.05) in SME, bulk density, and hydration time when the die temperature was increased from 90 to 140°C. Increasing the screw speed (180–300 rpm) led to an increase in SME, water solubility index (WSI), and water solubility, but a decrease of water solubility index (WAI). The optimal process parameters for processing the sinking feed pellets were moisture content: 26.6%, screw speed: 180 rpm, and die temperature: 113°C. These operation parameters provide a reference for the industrial production of fish feed with mixed plant protein sources.Practical applicationsIn recent years, plant protein has been increasingly developed as an aquatic feed source, but this has resulted in quality fluctuations for fish feed pellets. Sinking pellets require sufficient gelatinization but should avoid floating due to excessive swelling. Thus, it is important to control the parameters of the extrusion process during sinking feed production. Contrary to conventional laboratory studies, this study used a pilot extrusion line (capacity: 70–150 kg/hr) equipped with a steam adding preconditioner and an automatic data acquisition system for parameter optimization. Moreover, we defined satisfactory products through the targeted evaluation of key indicators such as water solubility and hydration time. The results of this study provide a reference for the industrial production of sinking feed with mixed plant proteins.

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“…400 nM of forward and reverse specific primers, 10 ng of cDNA template and nuclease‐free water to a final volume of 10 μl, then using the following programme: denaturation step at 95 °C for 1 min, followed by 40 amplification cycles of 5 s denaturation at 95 °C, 15 s annealing at 60 °C and 20 s extension at 72 °C, followed by a melt‐curve analysis and cooling to 4 °C. The information of primers for each gene is presented in Table 2 (Huang et al, 2019; Zhang et al, 2019).…”

Section: Methodsmentioning

confidence: 99%

Dietary lipid levels affected growth performance, lipid accumulation, inflammatory response and apoptosis of japanese seabass (lateolabraxjaponicus)

Xie

Lin

et al. 2021

Aquacult. Nutr.

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An eight weeks feeding trial was conducted to investigate the effects of dietary lipid levels on growth performance, lipid metabolism and immune response of Japanese seabass (Lateolabrax japonicus). Five diets were formulated with gradient dietary lipid levels (79.6, 104.4, 129.1, 154.9 and 178.6 g kg−1). Results revealed that growth and feed utilization of fish were significantly lower in group L178.6 than other groups (p < 0.05). Lipid accumulation in whole body, muscle and intraperitoneal were increased with increasing dietary lipid levels. The mRNA levels of adipose triglyceride lipase, carnitine palmitoyl transferase 1, acetyl CoA carboxylase, cholesterol 7 alpha‐hydroxylase and retinoid X receptor in liver were also increased with increasing dietary lipid levels (p < 0.05). The mRNA levels of apolipoprotein A1 and peroxisome proliferator activating receptor α were higher in fish fed L178.6 than those fed other diets. Oxidative stress in plasma and liver were induced when dietary lipid exceed 154.9 g kg−1. L154.9 and L178.6 significantly increased the inflammatory related gene expression of fish. These results suggested that high‐fat diet impaired the growth performance and induced lipid accumulation, inflammation and apoptosis of Japanese seabass. The suitable dietary lipid level of Japanese seabass may not exceed 129.1 g kg−1.

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Metabolic disorder induces fatty liver in Japanese seabass, Lateolabrax japonicas fed a full plant protein diet and regulated by cAMP-JNK/NF-kB-caspase signal pathway

Cited by 74 publications

References 53 publications

Adaptation of AMPK-mTOR-signal pathways and lipid metabolism in response to low- and high-rapeseed meal diet in Chinese perch (Siniperca chuatsi)

Adaptation of AMPK-mTOR-signal pathways and lipid metabolism in response to low- and high-rapeseed meal diet in Chinese perch (Siniperca chuatsi)

Optimization of the process parameters for extruded commercial sinking fish feed with mixed plant protein sources

Dietary lipid levels affected growth performance, lipid accumulation, inflammatory response and apoptosis of japanese seabass (lateolabraxjaponicus)

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