Metabolic Disorders in Menopause

Jeong, Hye Gyeong; Park, Hyuntae

doi:10.3390/metabo12100954

Cited by 55 publications

(34 citation statements)

References 103 publications

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“…Menopause and HF diet cause weight gain and glucose intolerance in App NL-F mice. Metabolic deficits have been observed in AD patients and postmenopausal women (3,24). In a mouse model of AD, we assessed differences in the effect of HF diet and menopause on several metabolic outcomes such as body weight, adiposity, and glucose tolerance.…”

Section: Resultsmentioning

confidence: 99%

“…Since the greatest risk factor for AD is advanced age, most women with AD are post-menopausal. Menopause is a mid-life endocrine transition during which women experience a loss of ovarian hormones, leading to increased risk for cognitive decline and dementia (23)(24)(25)(26)(27). This is in part due to the loss of the neuroprotective effects of estrogens, as well as the exacerbation of dementia risk factors (24,25,27,28), as menopause has been associated with increased weight gain and visceral fat accumulation, increased rates of type 2 diabetes, and altered brain glucose metabolism (29)(30)(31)(32).…”

Section: Introductionmentioning

confidence: 99%

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Effects of menopause and high fat diet on metabolic outcomes in a mouse model of Alzheimer’s disease

Abi-Ghanem,

Salinero,

Riccio

et al. 2023

Preprint

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About two-thirds of those with Alzheimer’s disease (AD) are women, most of whom are post-menopausal. Menopause accelerates the risk for dementia by increasing the risk for metabolic, cardiovascular, and cerebrovascular diseases. Mid-life metabolic disease (e.g. obesity, diabetes, or prediabetes) is a well-known risk factor for dementia. A high fat diet can lead to poor metabolic health in both humans and rodents. The goal of this study was to determine the effects of menopause and high fat diet on metabolic outcomes in the AppNL-Fknock-in mouse model of Alzheimer’s disease. To model menopause, we used an accelerated ovarian failure model (4-vinylcyclohexene diepoxide, VCD). This ovary-intact model is more clinically relevant than an ovariectomy model, as mice go through a perimenopausal period. At 3 months of age, AppNL-Fmice were administered VCD or vehicle (oil) and then placed on either a control diet (10% fat) or a high fat diet (HF; 60% fat) and maintained on the diets until 10 months of age. Menopause led to metabolic impairment (weight gain and glucose intolerance) and further exacerbated obesity in response to a high fat diet. Menopause had independent effects on some serum metabolic health biomarkers (insulin) and synergic effects with HF diet on other markers (glucagon). Some metabolic effects of menopause may be centrally mediated, as menopause altered the expression of hypothalamic genes related to energy balance and increased microgliosis in the lateral hypothalamic nucleus. This work highlights the need to model endocrine aging in animal models of dementia and will contribute to further understanding the interaction between menopause and metabolic health in the context of AD.HighlightsIn a mouse model of AD, menopause, modeled by accelerated ovarian failure, leads to metabolic impairment.Menopause has independent effects on some serum metabolic health biomarkers (insulin) and synergic effects with HF diet on other markers (glucagon).Menopause alters the expression of hypothalamic energy balance related genes.Menopause leads to increased microgliosis in the lateral hypothalamic nucleus.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of menopause and high fat diet on metabolic outcomes in a mouse model of Alzheimer’s disease

Abi-Ghanem,

Salinero,

Riccio

et al. 2023

Preprint

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“…Obesity often develops after menopause, which is related to immunogenetic background. Menopause (particularly premature) is associated with autoimmune or genetic diseases, infections, enzyme deficiencies, and metabolic syndrome [ 11 ]. Excessive fat tissue accumulation is associated with excessive pro-inflammatory cytokine synthesis, and causes regional inflammation [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have described the immunogenetic background of obesity, which increases after menopause and in the elderly [ 11 , 12 , 13 , 14 ]. They also showed the relevance of immunogenetic markers (HLA—human leucocyte antigens, cytokine genes, and some innate immunity genes) for successful aging and an increased life span.…”

Section: Introductionmentioning

confidence: 99%

The Influence of FAM13A and PPAR-γ2 Gene Polymorphisms on the Metabolic State of Postmenopausal Women

Grygiel-Górniak

Ziółkowska-Suchanek

Szymkowiak

et al. 2023

Genes

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Recently, we have observed two significant pandemics caused by communicable (COVID-19) and non-communicable factors (obesity). Obesity is related to a specific genetic background and characterized by immunogenetic features, such as low-grade systemic inflammation. The specific genetic variants include the presence of polymorphism of the Peroxisome Proliferator-Activated Receptors gene (PPAR-γ2; Pro12Ala, rs1801282, and C1431T, rs3856806 polymorphisms), β-adrenergic receptor gene (3β-AR; Trp64Arg, rs4994), and Family With Sequence Similarity 13 Member A gene (FAM13A; rs1903003, rs7671167, rs2869967). This study aimed to analyze the genetic background, body fat distribution, and hypertension risk in obese metabolically healthy postmenopausal women (n = 229, including 105 lean and 124 obese subjects). Each patient underwent anthropometric and genetic evaluations. The study has shown that the highest value of BMI was associated with visceral fat distribution. The analysis of particular genotypes has revealed no differences between lean and obese women except for FAM13A rs1903003 (CC), which was more prevalent in lean patients. The co-existence of the PPAR-γ2 C1431C variant with other FAM13A gene polymorphisms [rs1903003(TT) or rs7671167(TT), or rs2869967(CC)] was related to higher BMI values and visceral fat distribution (WHR > 0.85). The co-association of FAM13A rs1903003 (CC) and 3β-AR Trp64Arg was associated with higher values of systolic (SBP) and diastolic blood pressure (DBP). We conclude that the co-existence of FAM13A variants with C1413C polymorphism of the PPAR-γ2 gene is responsible for body fat amount and distribution.

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“…Although its etiology is not known exactly, it is estimated that the main factor in its development is endothelial dysfunction, insulin resistance and inflammation (Grandl and Wolfrum, 2018). Hormonal changes that begin with menopause, which is a result of aging in females, significantly increase the risk of obesity, type 2 diabetes, cardiovascular diseases and MetS (Jeong and Park, 2022). The decrease in estrogen/androgen ratio together with decreasing estrogen levels, and insulin resistance during and after menopause can lead to metabolic disorders by increasing the production of vasoconstrictive factors such as endothelin (Mehndiratta et al , 2020).…”

Section: Introductionmentioning

confidence: 99%

The relationship between dietary polyamine levels, metabolic risk parameters and anthropometric measurements in postmenopausal women

Tari Selcuk,

Atan,

Arslan

et al. 2024

NFS

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Purpose This study aims to investigate the relationship between dietary polyamine levels, metabolic risk parameters and anthropometric measurements in postmenopausal women. Design/methodology/approach This cross-sectional study was conducted with 562 45–64-year-old postmenopausal women who presented to a Family Health Center. To collect the data, the Descriptive Information Form and Food Frequency Questionnaire were used. In the data analysis, numbers, percentages, mean, standard deviation and multiple linear regression analysis were used. Findings The multiple linear regression analysis demonstrated that dietary putrescine intake was negatively associated with systolic blood pressure (ß = −0.179, p < 0.001), dietary spermidine intake was positively associated with waist circumference (WC) (ß = 0.142, p = 0.013), systolic blood pressure (ß = 0.188, p = 0.001), diastolic blood pressure (ß = 0.218, p < 0.001), body mass index (BMI) (ß = 0.169, p = 0.003) and waist-to-height ratio (WHtR) (ß = 0.156, p = 0.006), and dietary spermine intake was negatively associated with WC (ß = −0.158, p = 0.003), systolic blood pressure (ß = −0.195, p < 0.001), BMI (ß = −0.107, p = 0.042) and WHtR (ß = −0.138, p = 0.009). Research limitations/implications Owing to the study’s cross-sectional nature, the lack of succession in the cause–effect relationship, the use of self-report Food Frequency Questionnaire to determine dietary polyamine intake and the inability to analyze seasonal differences are among the limitations of the study. Originality/value In this study, an association was determined between dietary polyamines, metabolic risk parameters and anthropometric measurements. The findings suggest that dietary polyamines in human health should be further investigated owing to the increasing metabolic risk parameters.

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Metabolic Disorders in Menopause

Cited by 55 publications

References 103 publications

Effects of menopause and high fat diet on metabolic outcomes in a mouse model of Alzheimer’s disease

Effects of menopause and high fat diet on metabolic outcomes in a mouse model of Alzheimer’s disease

The Influence of FAM13A and PPAR-γ2 Gene Polymorphisms on the Metabolic State of Postmenopausal Women

The relationship between dietary polyamine levels, metabolic risk parameters and anthropometric measurements in postmenopausal women

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