Metabolic Dysfunction-Associated Steatotic Liver Disease Facilitates Hepatitis B Surface Antigen Seroclearance and Seroconversion

Factors Positively Correlated with Hepatitis B Surface Antigen Seroconversion in Chronic Hepatitis B

“…Likewise, Li et al retrospectively studied 6786 patients and identified that fatty liver was significantly and independently associated with a greater chance of achieving HBsAg seroclearance. The authors therefore conclude that metabolic dysfunctions have additive effects on the functional cure of chronic hepatitis B [48,49]. However, steatosis or related metabolic disorders were not associated with seroconversion in our cohort.…”

Epidemiology, natural history, and management of patients with CHB concurrent with MASLD

“…The authors showed that the corresponding 1-, 3-, and 5-year cumulative incidences of HBsAg seroclearance were 2.3%, 8.1%, and 12.0%, respectively, in the CHB-MASLD group, which were higher than the corresponding incidences of 1.2%, 3.7%, and 6.9% in the group with CHB and no MASLD. Further, compared to CHB patients with MASLD and 1-2 metabolic criteria, CHB patients with MASLD and ≥ 3 metabolic criteria had the highest HBsAg seroclearance rate 10 . Under the proposed criteria of MASLD, HS was identified as one of the most significant factors in HBsAg loss 10 .…”

“…Despite the uncertain impact of MASLD on fibrosis, cirrhosis, and HCC, evidence has shown that MASLD promotes HBsAg clearance. Huang SC et al [10] consecutively enrolled 4084 patients with CHB, of whom 21.7% combined with MASLD. The authors showed that the corresponding 1-, 3-, and 5-year cumulative incidences of HBsAg seroclearance were 2.3%, 8.1%, and 12.0%, respectively, in the CHB-MASLD group, which were higher than the corresponding incidences of 1.2%, 3.7%, and 6.9% in the group with CHB and no MASLD.…”

“…Further, compared to CHB patients with MASLD and 1-2 metabolic criteria, CHB patients with MASLD and ≥ 3 metabolic criteria had the highest HBsAg seroclearance rate. [10] Under the proposed criteria of MASLD, HS was identified as one of the most significant factors in HBsAg loss. [10] HBsAg seroclearance is an important marker for the functional cure of HBV infection.…”

“…[10] Under the proposed criteria of MASLD, HS was identified as one of the most significant factors in HBsAg loss. [10] HBsAg seroclearance is an important marker for the functional cure of HBV infection. Several hypotheses have been proposed to elucidate the connection between fatty liver and HBsAg seroclearance.…”