Metabolic dysfunction: The silenced connection with fatty liver disease

Ramírez-Mejía, Mariana M; Qi, Xingshun; Abenavoli, Ludovico; Romero‐Gómez, Manuel; Eslam, Mohammed; Méndez-Sánchez, Nahúm

doi:10.1016/j.aohep.2023.101138

Cited by 11 publications

(4 citation statements)

References 68 publications

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“…The theory of multiple blows is currently a recognized pathogenesis of MAFLD[ 10 , 11 ]. Although multiple hits like diet, obesity, insulin resistance, genetic factors, and gut dysbiosis have been found to contribute to MAFLD pathogenesis, environmental toxins or pollutants were barely mentioned in previous literature[ 12 , 13 ]. Recently, multiple models have demonstrated that the liver can be insulted by MPs through ROS generation, directly or indirectly resulting in MAFLD.…”

Section: Oxidative Stressmentioning

confidence: 99%

Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions

Chiang,

Yeh,

Shiu

et al. 2024

World J Gastroenterol

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With continuous population and economic growth in the 21st century, plastic pollution is a major global issue. However, the health concern of microplastics/ nanoplastics (MPs/NPs) decomposed from plastic wastes has drawn public attention only in the recent decade. This article summarizes recent works dedicated to understanding the impact of MPs/NPs on the liver-the largest digestive organ, which is one of the primary routes that MPs/NPs enter human bodies. The interrelated mechanisms including oxidative stress, hepatocyte energy re-distribution, cell death and autophagy, as well as immune responses and inflammation, were also featured. In addition, the disturbance of microbiome and gut-liver axis, and the association with clinical diseases such as metabolic dysfunction-associated fatty liver disease, steatohepatitis, liver fibrosis, and cirrhosis were briefly discussed. Finally, we discussed potential directions in regard to this trending topic, highlighted current challenges in research, and proposed possible solutions.

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Section: Oxidative Stressmentioning

confidence: 99%

Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions

Chiang,

Yeh,

Shiu

et al. 2024

World J Gastroenterol

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“…Non-alcoholic fatty liver disease (NAFLD) currently stands as a predominant contributor to chronic liver diseases worldwide, with an estimated prevalence of approximately 30% [ 1 ]. Recently, it was renamed a metabolic (dysfunction)-associated fatty liver disease (MAFLD) in order to emphasise the underlying metabolic dysfunction [ 2 , 3 ]. However, owing to the lack of consensus among all expert committees, the term NAFLD is used throughout the present manuscript.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gracilaria vermiculophylla Macroalga on Non-Alcoholic Fatty Liver Disease in Obese Rats

González-Arceo,

Aguirre,

Macarulla

et al. 2024

Antioxidants

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Marine algae are valuable sources of bioactive compounds that have the potential to be used in the management of various pathologies. Despite the increasing prevalence of NAFLD, the absence of an approved effective pharmacological treatment with demonstrable effectiveness persists. In this context, the aim of the present study is to assess the effect of Gracilaria vermiculophylla red seaweed dietary supplementation on hepatic lipid accumulation, as well as on oxidative stress, inflammation and fibrosis- related markers on obese fa/fa Zucker rats fed with a standard diet, supplemented or not with 2.5% or 5% dehydrated Gracilaria vermiculophylla. After a six-week supplementation with the macroalga, no significant reduction in hepatic total lipid content or hepatic triglyceride content was observed. However, both doses were able to diminish hepatic NEFA concentration by reducing de novo lipogenesis and increasing mitochondrial biogenesis. Moreover, supplementation with the dose of 2.5% improved some oxidative stress and inflammation-related markers. Supplementation with the dose of 5% did not exert these clear beneficial effects. Thus, this study demonstrates that while Gracilaria vermiculophylla may not mitigate hepatic steatosis, it could exert protective effects on the liver by reducing NEFA content and enhancing oxidative stress and inflammation parameters.

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“…Numerous studies have shown a strong association between NAFLD and metabolic syndrome [ 3 ]. In fact, metabolic-dysfunction-associated steatotic liver disease (MASLD) has recently been suggested as the preferred terminology for fatty liver disease associated with metabolic syndrome [ 4 ]. Unfortunately, the only interventions with proven benefits in NAFLD are limited to lifestyle modifications, primarily weight loss and increased physical activity, to which adherence is often difficult.…”

Section: Introductionmentioning

confidence: 99%

Prebiotic Treatment in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)—A Randomized Pilot Trial

Reshef,

Gophna,

Reshef

et al. 2024

Nutrients

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Several studies show that gut microbiotas in patients with nonalcoholic fatty liver disease (NAFLD) differ from those in a healthy population, suggesting that this alteration plays a role in NAFLD pathogenesis. We investigated whether prebiotic administration affects liver fat content and/or liver-related and metabolic parameters. Patients with NAFLD and metabolic syndrome (age: 50 ± 11; 79% men) were randomized to receive either 16 g/day of prebiotic (ITFs—inulin-type fructans) (n = 8) or placebo (maltodextrin) (n = 11) for 12 weeks. Patients were instructed to maintain a stable weight throughout the study. Liver fat content (measured by H1MRS), fecal microbiota, and metabolic, inflammatory, and liver parameters were determined before and after intervention. Fecal samples from patients who received the prebiotic had an increased content of Bifidobacterium (p = 0.025), which was not observed with the placebo. However, the baseline and end-of-study liver fat contents did not change significantly in the prebiotic and placebo groups, neither did the liver function tests’ metabolic and inflammatory mediators, including fibroblast growth factor-19 and lipopolysaccharide-binding protein. Body weight remained stable in both groups. These findings suggest that prebiotic treatment without weight reduction is insufficient to improve NAFLD.

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Metabolic dysfunction: The silenced connection with fatty liver disease

Cited by 11 publications

References 68 publications

Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions

Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions

Effect of Gracilaria vermiculophylla Macroalga on Non-Alcoholic Fatty Liver Disease in Obese Rats

Prebiotic Treatment in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)—A Randomized Pilot Trial

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