2024
DOI: 10.3390/ijms25073857
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Metabolic Dysregulation and Its Role in Postoperative Pain among Knee Osteoarthritis Patients

Elena V. Tchetina,
Kseniya E. Glemba,
Galina A. Markova
et al.

Abstract: Knee osteoarthritis (KOA) is characterized by low-grade inflammation, loss of articular cartilage, subchondral bone remodeling, synovitis, osteophyte formation, and pain. Strong, continuous pain may indicate the need for joint replacement in patients with end-stage OA, although postoperative pain (POP) of at least a two-month duration persists in 10–40% of patients with OA. Study purpose: The inflammation observed in joint tissues is linked to pain caused by the production of proinflammatory cytokines. Since t… Show more

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