Metabolic Effects in Man of Steroids With Progestational Activity

Landau, Richard L.; Lugibihl, Kathleen; Dimick, Dean F.

doi:10.1111/j.1749-6632.1958.tb46790.x

Cited by 24 publications

(4 citation statements)

References 10 publications

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“…The supportive effect of this anabolic state on the overall status of the patients has been notable. Similar beneficial effects have been reported in cases of tuberculosis, chronic bronchitis, bronchiectasis, emphysema, and asthma using other anabolic steroids 8,6. Estrogens are anabolic7 and have longbeen used to treat infections of squamous epithelial structures and associated glandular elements and have demonstrable effects on other nonsquamous epithelial linings such as the nasal membranes, the endometrium, and the breast.…”

supporting

confidence: 52%

Anabolic Steroids in Cystic Fibrosis of the Pancreas

Good¹,

Bessman²

1966

Arch Pediatr Adolesc Med

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MANY CHILDREN with cystic fibrosis show malnutrition of increasing severity as they grow older.1 As we had observed that the development of severe anorexia is frequently a terminal event in fibrocystic disease, we tried, as a last resort, "artificial" stimulation of appetite by an anabolic steroid in large dosages in a terminal case. The dramatic result prompted us to extend the observation to other advanced cases. This report deals with six patients treated with large dosages of anabolic steroid, estrogen, or progestational compounds.Report of Cases Case 1.\p=m-\Acase of cystic fibrosis was diagnosed for this girl at the age of 6 years when she had bilateral emphysema and perihilar infiltrations by chest x-ray, negative stool trypsin, and a sweat chloride of 71 mEq/liter. The course of her disease fluctuated with recurrent episodes of pneumonia, appetite failure, weight loss, inanition, and psychic depression. As may be seen from her growth grid (Fig 1), four major periods of weight plateau or serious loss were seen. These periods resulted in hospitalization for inten¬ sification of specific antibiotic therapy, aerosol mist, and postural drainage for treatment of pneumonia. In her ninth year of life, control of lung infection became increasingly difficult and inanition became extreme. She was hospitalized without apparent improvement in appetite and general health even though some control of lung infection was effected. At this time (age of 10 years) she appeared to be in the state of severe disease which has heralded the death of previous patients. Methandrostenolone (Dianabol) was started at the dosage of 10 mg/ day. Appetite increase occurred after two weeks and progressed to a voracious food intake. Within ZYi months she had gained 8 kg (17 lb 10 oz) and had grown 3 cm (1]4 inches).She continued to show accelerated weight gain, height increments, and good general health on methandrostenolone. The intermittent use of so¬ dium oxacillin administered orally and saline aero¬ sol were associated with clearing of rales and rhonchi from her chest. Her lips lost their cyanosis, and clubbing of the fingers decreased. Because of the appearance of moderate acne, pubic hair, mild clitoral hypertrophy, and some lowering of the voice, the dosage of methandrostenolone was de¬ creased to 5 mg per day. Weight gain slowed, linear growth continued, and her general health remained good over a period of four more months. Further lowering of dosage to 2.5 mg/day was followed by recurrence of signs and symptoms of lower respira¬ tory tract infection which resulted in rehospitalization. Marked appetite failure, weight loss, and depression recurred. More intensive treatment with specific antibiotics, mist, and postural drainage resulted again in some return of well being but appetite was sporadic and weight loss continued. Because methandrostenolone in dosage of 10 mg/day failed to have appreciable effect over a one-month period, estrogens were added to the regimen in the form of estradiol valerate (EV) (Delestrogen), 20 mg every t...

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supporting

confidence: 52%

Anabolic Steroids in Cystic Fibrosis of the Pancreas

Good¹,

Bessman²

1966

Arch Pediatr Adolesc Med

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“…Progestogens with an alpha substitute at position C-17, however, may have the reverse effect on aldosterone secretion by promoting sodium retention (Landau, Lugibihl, and Dimick, 1958). The progestogens used in this study were of the latter type and the lack of response of plasma aldosterone in this study may have been due to a balance between the stimulating effects of oestrogen and the suppressing effects of the progestogen.…”

Section: Changes In Renin Renin Substrate and Corticosteroidsmentioning

confidence: 76%

Effect of oral contraceptives on blood pressure and on plasma renin, renin substrate, and corticosteroids

Weir¹,

Fraser²

1969

Journal of Clinical Pathology

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SYNOPSIS A rise in blood pressure associated with oral contraceptives is well established but the frequency with which it develops is not known. Early results from a controlled long-term prospective study have shown no significant change in mean systolic or diastolic pressures or mean weight in 31 women after four months on oral contraceptives. In no individual subject was there a significant change in blood pressure or weight over the short period of the experiment.In 10 women, oral contraceptives have been shown to induce a consistent rise in plasma renin substrate and cortisol concentrations after four weeks. At this time plasma renin concentration had fallen slightly in eight out of 10 women but neither plasma aldosterone nor plasma corticosterone showed any consistent response.Raised blood pressure (above 140/90 mm Hg) associated with oral contraceptives has been reported on several occasions but the incidence of hypertension in women taking these drugs is not known. Changes in renin substrate, renin, and aldosterone secretion and excretion have also been observed, but no direct relationship between these factors and the rise in blood pressure has yet been established. This paper is arranged in two sections: a short review of blood pressure and endocrine changes during the administration of oral contraceptives followed by a preliminary report of a study of their effects on the plasma concentrations of renin, renin substrate, aldosterone, corticosterone, and cortisol.

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“…It seems possible that the pre-ovulatory 17-OH-progesterone elevation (Abraham et al 1972) triggers a pre-ovulatory aldosterone peak although it is known that 17-OH-progesterone has no Na-diuretic effect (Landau et al 1958). …”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Unconjugated Aetiocholanolone, Androstenedione, Testosterone, Dehydroepiandrosterone, Aldosterone, Progesterone and Oestrogens During the Normal Menstrual Cycle

Frölich

Brand

Hall

1976

Acta Endocrinologica

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The results of daily determination of the levels of gonadotrophins, oestradiol, oestrone, progesterone, aldosterone, dehydroepiandrosterone, androstenedione, testosterone, and aetiocholanolone in the serum of 6 normal, ovulating women are reported and discussed. A pre-ovulatory aldosterone peak and rising values in the luteal phase of the cycle were found. Androstenedione, testosterone, and aetiocholanolone levels were significantly elevated from 3 days before until 3 days after ovulation. Since the mean androstenedione/aetiocholanolone ratio in the individual cycles in this period was similar to the ratio found during the rest of the cycle, we think it unlikely that aetiocholanolone is produced by the ovaries. No correlation was found between the aetiocholanolone patterns and the basal body temperature. In a case of conception followed for 20 days after ovulation, the steroid patterns remained unchanged until the presumed day of implantation, after which the aldosterone, androstenedione, testosterone, and aetiocholanolone levels started to rise. The mean androstenedione/aetiocholanolone ratio during the 10 days after implantation did not differ from the values obtained in the foregoing periods, so direct aetiocholanolone production by the ovaries after implantation seems unlikely.

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Metabolic Effects in Man of Steroids With Progestational Activity

Cited by 24 publications

References 10 publications

Anabolic Steroids in Cystic Fibrosis of the Pancreas

Anabolic Steroids in Cystic Fibrosis of the Pancreas

Effect of oral contraceptives on blood pressure and on plasma renin, renin substrate, and corticosteroids

Serum Levels of Unconjugated Aetiocholanolone, Androstenedione, Testosterone, Dehydroepiandrosterone, Aldosterone, Progesterone and Oestrogens During the Normal Menstrual Cycle

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