Metabolic effects induced by chronic stress in the amygdala of diabetic rats: A study based on ex vivo 1H NMR spectroscopy

Xu, Wen; Zang, Yirou; Shen, Qijun; Shan, Yanna; Han, Bing; Zhou, Huiyun; Lai, Xufeng

doi:10.1016/j.brainres.2019.146377

Cited by 4 publications

(2 citation statements)

References 55 publications

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“…Due to the deviation of metabolite concentration in the feces of each mouse, each bucket was internally normalized to the total sum of the spectral integrals prior to pattern recognition analysis. The characteristic peaks of all fecal metabolites were determined based on related literature [ 27 , 28 ] and HMDB.…”

Section: Methodsmentioning

confidence: 99%

Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis

Zhang

Zhou

Chen

et al. 2022

Oxidative Medicine and Cellular Longevity

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The anxiety and depression caused by inflammatory bowel diseases (IBD) are known to greatly affect the mental health of patients. The mechanism of psychiatric disorders caused by IBD is not fully understood. Previous research has suggested that the gut microbiome plays a key role in IBD. Curcumin is a yellow polyphenol extracted from the rhizome of the ginger plant, which has been shown to have effects against both depression and anxiety. Research has indicated that curcumin affects the gut microbiome and exerts antianxiety and neuroprotective effects through the microbiota-gut-brain axis (MGB). However, whether curcumin can alleviate the psychiatric disorders caused by IBD and how curcumin affects the MGB axis through the gut microbiota have not been fully understood. Therefore, this study was aimed at determining the metabolic parameters and microbiological environment in the peripheral and central nervous system to determine the effects of curcumin against anxiety induced by dextran sulfate sodium salt (DSS) in mice. To elaborate on the link between the gut microbiota and how curcumin alleviates anxiety-like behaviors, we performed a fecal microbiota transplantation (FMT) experiment. The results suggested that curcumin can effectively relieve anxiety-like behaviors caused by DSS in mice. Further, curcumin treatment can alleviate disturbances in the gut microbiota and systemic disorders of lipid metabolism caused by DSS. Finally, through FMT, we verified that curcumin increased phosphatidylcholine in the prefrontal cortex of the mice and alleviated DSS-induced anxiety-like behaviors by modulating specific gut microbiota. We also revealed that Muribaculaceae may be a key part of the gut microbiota for curcumin to alleviate DSS-induced anxiety-like behaviors through the MGB axis.

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Section: Methodsmentioning

confidence: 99%

Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis

Zhang

Zhou

Chen

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Por ejemplo, en investigaciones de inducción de estrés agudo en ratas, se logra evidenciar que existe un aumento del fenotipo proinflamatorio de los macrófagos periféricos hepáticos, un aumento de la expresión de la sintasa de óxido nítrico inducida y un aumento de la activación de la vitamina D. (26) En tanto, en el estrés crónico se producen cambios neuroplásticos ante la respuesta de un estresor que al inicio fue agudo, pero luego al convertirse en sostenido abrumó los mecanismos de retroalimentación regulatorios, generando cambios estructurales y funcionales básicos para la generación de eventos desfavorables para el individuo (27) . Estudios en ratones evidencian la relación que existe entre el estrés crónico y el desarrollo de anomalías estructurales y funcionales de la amígdala, la corteza e hipocampo, reduciendo los niveles de glutamato, acetilaspartato y colina, pero aumentando los niveles de creatina y mioinositol, lo que generaría agotamiento celular; así como también la activación permanente y no controlada del eje HHS, desencadenando hiperglicemia por la liberación constante de catecolaminas y corticosteroides (28,29) . Algunos estudios incluso relacionan al estrés crónico con la reducción marcada de los niveles de dopamina y serotonina en ratones con inducción de enfermedades neurodegenerativas como el Parkinson, acelerando la progresión de la enfermedad.…”

Section: Bases Teóricasunclassified

Estrés agudo y crónico en la reparación ósea: un enfoque actualizado desde las Neurociencias.

Ruiz-Ramírez

Becerra-Bravo

Lam-Figueroa

2022

Rev. chil. neuro-psiquiatr.

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The physiological molecular mechanisms associated with the response to acute and chronic stress allow us to understand the changes that these can produce in the various tissues of the body. Various investigations highlight the role of chronic stress in the development of dysfunctions that affect body balance; However, it must be considered that the mechanisms related to acute stress can also influence the development of pathologies and the progression of the deleterious manifestations of chronic stress. On the other hand, one of the most studied tissues in recent years has been bone tissue, since it is influenced by nervous, endocrine and immunological factors. This paper seeks to analyze the neuroscientific bases of the molecular mechanisms of stress and their relationship in the bone repair process. Therefore, a literature search was carried out in the Pubmed, Scopus and ScienceDirect databases. Concluding that stress modifies the release of neurotransmitters, the action of the autonomic nervous system, the release of corticotropic hormones and the activity of various cytokines; which leads to the imbalance of the regulation and repair processes of the bone tissue subjected to load or injury.

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5-Fluorouracil induced dysregulation of the microbiome-gut-brain axis manifesting as depressive like behaviors in rats

Zhang

Chen

Zhang

et al. 2020

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Metabolic effects induced by chronic stress in the amygdala of diabetic rats: A study based on ex vivo 1H NMR spectroscopy

Cited by 4 publications

References 55 publications

Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis

Curcumin Alleviates DSS-Induced Anxiety-Like Behaviors via the Microbial-Brain-Gut Axis

Estrés agudo y crónico en la reparación ósea: un enfoque actualizado desde las Neurociencias.

5-Fluorouracil induced dysregulation of the microbiome-gut-brain axis manifesting as depressive like behaviors in rats

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