Metabolic effects of calcitonin in the newborn

Jm, Garel; Barlet, J.P.; Kervran, A.

doi:10.1152/ajplegacy.1975.229.3.669

Cited by 12 publications

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“…So, STH, catecholamines and cortisol levels in blood increase under the effect of CT [13,14], i.e. CT also indirect can promote to the development of IR.…”

Section: Calcitonin and Insulin Resistancementioning

confidence: 99%

Calcitonin Participant in the Development of Insulin Resistance

Moisa¹

2017

JBiSE

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The review contains contemporary literature data about calcitonin role in the development of insulin resistance and its potential role in the pathogenesis of carbohydrate metabolism disturbances. Analogues disturbances revealed under diabetes mellitus and under calcitonin treatment are considered. Literature data about hormone diabetogenicity are discussed. The analysis of experimental and literature data testifies that calcitonin under unfavorable conditions (age, obesity, stress) against the background of the decreasing of functional activity of insular apparatus can lead to the development of metabolic syndrome and diabetes mellitus. It is shown that calcium channel blockers inhibit calcitonin effect leads to glucose intolerance and decreases tissue insulin sensitivity. In this connection a question about direct influence on calcium mechanisms of endocrine system as possible method of drug therapy is discussed.

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“…So, STH, catecholamines and cortisol levels in blood increase under the effect of CT [13,14], i.e. CT also indirect can promote to the development of IR.…”

Section: Calcitonin and Insulin Resistancementioning

confidence: 99%

Calcitonin Participant in the Development of Insulin Resistance

Moisa¹

2017

JBiSE

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“…The tissue distribution of radioactivity 4 h after forcefeeding illustrated the decrease in the absorption of labelled triolein. The distribution of radioactivity in control animals was very high in brown adipose tissue, but low in liver, kidney, muscle and bone ; 3 h after CT injection, the distribution of radioactivity for each organ studied was less in the CT group than in control animals (Garel, Barlet and Kervran, 1975). In newborn lambs, a physiological dose of porcine CT inhibited the elevation in plasma of total lipid, glucose and amino acid concentrations due to the first suckling period (fig.…”

mentioning

confidence: 92%

“…The hypocalcemic and hypophosphatemic effects of CT were more intense in the newborn rat than in rat fetus (Garel, 1969 ; Garel and Barlet,1974) ; the newborns were also more sensitive to the hormone since subcutaneous injection of a lower dose (1:5) markedly decreased plasma calcium and inorganic phosphorus concentrations . The injection of a large dose of CT in the suckling newborn rat had a clearing effect on plasma which was naturally lactescent (Garel, Barlet and Kervran, 1975). The clearing effect of CT was the result of a decrease in plasma lipids, as shown by the decrease in plasma triglyceride concentration ( fig.…”

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confidence: 99%

Calcitonin in the mother, fetus and newborn

Garel¹,

Barlet²

1978

Ann. Biol. anim. Bioch. Biophys.

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Summary. The high plasma calcitonin level in the mother during gestation and lactation protected the maternal skeleton against excessive demineralization. The relative independence of fetal calcemia from the maternal plasma calcium concentration was well established and the concept of hormonal autonomy of fetal secretion of parathyroid hormone and calcitonin developed. However, the role of these hormones during fetal life remained obscure. A new aspect of calcitonin physiology in the newborn, the regulation of nutrient absorption through gastric emptying, is mentioned.The mother.Calcium needs are increased in the female during gestation and lactation. Comar (1956) has shown that the transfer of calcium through the placenta and the mammary gland is greatest at the end of gestation and during lactation, respectively.Kinetic studies using calcium 45 demonstrated that fetal and newborn calcium contents were originated from maternal intestinal absorption and/or maternal skeleton, the relative importance of the two contributions being species-dependent. According to Wasserman et al. (1957), 92 p. 100 of the fetal calcium in rat is of maternal dietary origin. In contrast, intestinal calcium absorption in ruminants is not sufficient to cover th e calcium needs of the fetus or of the newborn in lactating cows (Symonds et al., 1966) and in pregnant ewes (Braithwaite, Glascock and Riazuddin, 1969 ;Braithwaite, Glascock and Riazuddin, 1970), the calcium being supplied by maternal bone resorption.In many species, the intestinal absorption increases. Chef (1969) (Garel, 1970a ;Pic, Maniey and Jost, 1965 ;Pic, 1973) which is corrected by parathyroid extract injection (Garel, Pic and Jost, 1971) (table 1). Thyroparathyroidectomy in rat fetus delayed recovery from EDTA-induced hypocalcemia (Garel, 1975). Higher calcemia in the fetus than in the mother in thyroparathyroidectomized rat fetus from thyroparathyroidectomized mother (Pic, 1968) (Garel, Milhaud and Jost, 1968). A larger dose (140 MRC mU/g body weight of salmon CT) must be given to decrease the fetal plasma magnesium level . In preliminary experiments, Littledike, Arnaud and Whipp (1972) have shown that CT injected intravenously into fetal piglet had no effect on plasma calcium levels in contrast to newborn piglet. In Rhesus monkey fetus, CT induced a triphasic effect with time on the plasma calcium level : a rapid decline, followed by recovery, and then a sluggish decrease (Reynolds, Pitkin and Wezeman, 1975 The Newborn.The placental outflow of calcium disappears at birth and the plasma calcium level decreases sharply in newborn rat (Garel, 1969). The hypocalcemic and hypophosphatemic effects of CT were more intense in the newborn rat than in rat fetus (Garel, 1969 ; Garel and Barlet,1974) ; the newborns were also more sensitive to the hormone since subcutaneous injection of a lower dose (1:5) markedly decreased plasma calcium and inorganic phosphorus concentrations . The injection of a large dose of CT in the suckling newborn rat had a clearing effect on plasma ...

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“…7). Garel, Barlet and Kervran (1975) have shown that CT decreased plasma triglyceride levels in suckling newborn rats mainly by inhibiting gastric emptying. It was also observed that a physiological dose of CT inhibited the elevation of plasma concentrations of total lipids, amino acids and glucose occurring after suckling in newborn lambs.…”

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confidence: 97%

Hormonal regulation of calcium metabolism in the newborn

Barlet¹,

Garel²

1978

Ann. Biol. anim. Bioch. Biophys.

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Summary. The parathyroid status at birth is species-dependent. In some species, it has been suggested that in utero, high plasma calcium levels inhibit the parathyroid function before birth, but other unknown factors may be involved in this suppression. The maturity of the renal cortex adenyl-cyclase activity in the early postnatal period is also species-dependent, and the degree of renal immaturity is not sufficient to explain the postnatal increase in plasma phosphates. (Garel, 19696 ; (fig. 5) Calcitonin.Our group was one of the first to report high plasma CT levels in the newborn (Garel et al., 1973). Plasma CT levels are generally higher in newborns such as lambs (Garel, Care and Barlet, 1974), foals (Garel, Martin-Rosset and Barlet, 1975), calves and rats (Garel and Jullienne, 1977) than in the dams or adults. High CT levels were also reported in human newborns (Hesch et al., 1973 ;Samaan, Anderson and Adam-Mayne, 1975). Factors which control the high plasma CT level in the newborn are still poorly understood.In 15-day old calves, the lack of hypocalcemic response following the intravenous infusion of purified porcine CT (Barlet, 1968) or the hypercalcemic perfusion of the thyroid gland isolated in situ (Phillippo, Care and Hinde, 1969) (1970) found that the CT content of rat thyroid measured by bioassay did not change significantly with age after 30 days, although suckling animals had markedly lower thyroid CT contents. In suckling newborn rats, the plasma CT concentration was always significantly higher than the levels found in virgin female rats (Garel and Jullienne, 1977). Rat milk is rich in triglycerides ; since exogenous CT decreased plasma triglycerides in suckling newborn rats, soybean oil was used as a CT secretagogue. The triglyceride composition of the soybean oil resembles the triglyceride composition of rat milk. One hour after administration of soybean oil by force-feeding, the plasma CT level was significantly increased in the 2-hour old newborn rat (Garel and Jullienne, 1977). In a

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Metabolic effects of calcitonin in the newborn

Cited by 12 publications

References 0 publications

Calcitonin Participant in the Development of Insulin Resistance

Calcitonin Participant in the Development of Insulin Resistance

Calcitonin in the mother, fetus and newborn

Hormonal regulation of calcium metabolism in the newborn

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