Metabolic effects of three different inotropic strategies in the newborn piglet myocardium

Abstract

Milrinone and adrenaline induced significantly higher lactate levels in neonatal piglets. The increase was not caused by myocardial ischaemia, but rather due to a beta-stimulation-induced glycolysis.

Dopamine plasma clearance is increased in piglets compared to neonates during continuous dopamine infusion

“…Dopamine plasma pharmacodynamics has been studied in both piglets and neonates , but dopamine plasma pharmacokinetics has only been investigated in human neonates . To allow clinicians to translate experimental findings from piglet studies to clinical treatment protocols in neonatology, we studied dopamine steady‐state plasma clearance during dopamine infusion in both piglets and neonates and described the dopamine plasma pharmacokinetics in piglets.…”