2023
DOI: 10.3389/fendo.2023.1176199
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Metabolic effects of vasopressin in pathophysiology of diabetic kidney disease

Svetlana Lebedeva,
Arus Margaryan,
Elena Smolyarchuk
et al.

Abstract: The diabetic kidney disease (DKD) is the major cause of the chronic kidney disease (CKD). Enhanced plasma vasopressin (VP) levels have been associated with the pathophysiology of DKD and CKD. Stimulation of VP release in DKD is caused by glucose-dependent reset of the osmostat leading to secondary pathophysiologic effects mediated by distinct VP receptor types. VP is a stress hormone exhibiting the antidiuretic action in the kidney along with broad adaptive effects in other organs. Excessive activation of the … Show more

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