Metabolic Effects of Water Deprivation

Abstract

Summary ·1. Under the conditions öf pair feeding, water-deprived rats predominantly use fat äs a metabolic fuel, whereas total energy turnover äs measured by oxygen consumption is not altered. t.2. Plasma free fatty acids are elevated in dehydrated rats, indicating enhanced lipolysis.. 3. Reduced hepatic fatty acid synthesis and reduced triacylglycerol secretion into the blood seem to be the main factors for the decfease of plasma triacylglycerol, observed 48 hours after the onset of water j deprivation.4. Enhanced plasma levels of corticosterone (about 100%) and glucagon (about 50%) may contribute to the ; metabolic Situation observed in water deprivation.

Risk factor assessment for breast cancer in North Cyprus: a comprehensive case-control study of Turkish Cypriot women

“…Other studies have also supported the beneficial effect of drinking water on various cancers including bladder cancer, colorectal cancer, and BC prevention (24). Water may play a role in the removal of cellular carcinogens as chronic dehydration may alter the intracellular water concentration, affect the enzymatic activity in metabolic regulations, and inhibit removal of carcinogens from cells (25). The relationship between oil or fat intake and BC is unclear; however, there is evidence that lower fat intake reduces the concentration of bioavailable serum sex hormones (26,27), which are the main risk factors for BC.…”

Relation between hydration status in children and their dietary profile – results from the DONALD study

“…The increase was enhanced by treatment with antidiuretic hormone, which causes a positive water balance (Tordoff and Friedman, 1989). Another study with rats observed that dehydration caused intracellular changes in the activity of enzymes involved in lipid metabolism, and that in water-deprived rats lipids became the predominant metabolic fuel (Hohenegger et al, 1986). Similarly, an experiment with weaned grey seal pups showed that metabolic water from lipid-oxidation was the primary source of water for the pups if they had no free access to water (Reilly, 1991).…”

“…For example, in an experimental study with rodents, prolonged water deprivation since weaning resulted in higher food intake among the water deprived animals as compared with controls (Sahni et al, 1987). Other experimental studies with water-deprived rats and seal pups have shown that dehydration has stimulating effects on lipid metabolism, as fat is the most efficient source of metabolic water (Hohenegger et al, 1986;Reilly, 1991). In an experimental study with human subjects, extended fluid restriction (up to 37 h) lead to a decrease in energy intake owing to a decrease in protein and carbohydrate intake, but no reduction in fat intake (Shirreffs et al, 2004).…”

Reduced water intake: Implications for rodent developmental and reproductive toxicity studies

“…A study in rhesus monkeys indicates that cellular, rather than extracellular, fluid depletion was the key stimulus eliciting drinking behavior (Wood et al, 1982). Faced with restricted water intake, animals have some ability to compensate by reducing fluid loss (Dicker and Nunn, 1957; Collier and Levitsky, 1967; Fitzsimons and Le Magnen, 1969; Hohenegger et al, 1986). Severe water restriction induces “voluntary” fasting, such that the ratio of body water to body weight is conserved as far as possible (Collier and Levitsky, 1967; Hohenegger et al, 1986; Hughes et al, 1994).…”