Metabolic Evaluation in Stone Disease Metabolic Differences Between the Pediatric and Adult Patients With Stone Disease

Karabacak, Osman Raif; Ipek, Bulent; Öztürk, Ufuk; Demirel, Fatih; Saltas, Hakan; Altuğ, Uğur

doi:10.1016/j.urology.2010.01.036

Cited by 38 publications

(21 citation statements)

References 22 publications

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“…En ninguno de los dos casos según sexos, la hipercalciuria es el factor más prevalente. Estos factores contrastan y son diferentes a los obtenidos en otras regiones y países del mundo en donde la hipocitraturia es el factor más prevalente (16,17), o bien la hiperoxaluria (18), o la hipercalciuria (19,20). En relación al análisis de los factores de riesgo según el pH urinario, coincidimos con otro estudio (21), en que los pacientes con pH de orina en rango 5.5-7 presentan unos niveles de citrato más bajos, y por tanto más riesgo litógeno en relación a este factor metabólico.…”

Section: Discussionunclassified

Study of lithogenic factors in men and women with recurrent nephrolithiasis in the north area of Almeria

Cano-García¹,

Roletto-Salmo²,

Hidalgo-Agulló³

2015

Actual. Med.

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Estudio de factores litogénicos en hombres y mujeres con litiasis urinaria recidivante en el área norte de Almería ResumenObjetivos: Estudiar los principales factores litogénicos en hombres y mujeres con litiasis urinaria recidivante en un área geográfica concreta. Material y Métodos: Estudio transversal que incluye 94 pacientes con litiasis urinaria recidivante desde junio 2014-enero 2015, en los que se realiza evaluación metabólica en sangre, orina ayunas y orina de 24 horas. Se comparan resultados medios de los parámetros estudiados según sexos y porcentaje de los principales factores de riesgo litogénicos. Estudio estadístico con SPSS 20.0, considerando significación estadística p≤0.05. Resultados: De los 94 pacientes incluidos, 60 fueron hombres y 34 mujeres, con edades medias de 49 y 51 años respectivamente, sin diferencias significativas. Los hombres presentan mayor excreción urinaria de calcio, úrico, oxalato y sodio que las mujeres y un mayor porcentaje de hiperuricosuria (>750 mg/24h) respecto a las mujeres. En las mujeres destaca en relación a los hombres un mayor porcentaje de hipovitaminosis D (<20ng/ml). La excreción de sodio se relaciona con la excreción de diferentes factores de riesgo litógeno, entre ellos el calcio. Los pacientes con pH en rango 5.5-7 presentan niveles de citrato más bajos que pacientes con pH<5.5. Conclusión:El estudio de factores litogénicos con evaluación metabólica tiene interés por los cambios que se producen según las regiones estudiadas y según otros factores como el sexo y el pH urinario. AbstractObjectives: To study the main lithogenic factors in men and women with recurrent nephrolithiasis in a particular geographical area. Material and Methods: Cross-sectional study including 94 patients with recurrent nephrolithiasis from June 2014 to January 2015, in which metabolic evaluation is performed on blood, fasting urine and 24 hours urine. Average results of the parameters studied by sex and percentage of the main lithogenic risk factors are compared. Statistical analysis with SPSS 20.0, considering statistical significance p≤0.05. Results: Of the 94 patients enrolled, 60 were men and 34 women, with mean ages of 49 and 51 years respectively, without significant difference. Men have higher urinary excretion of calcium, uric, sodium and oxalate respect women and men presented a higher percentage of hyperuricosuria (> 750 mg / 24 h) compared to women. In women, respect men, presented higher percentage of hypovitaminosis D (<20 ng / ml). Urinary sodium excretion is related to different lithiasis risk factors, including calcium. Patients with pH range 5.5-7 presented lower levels of citrate than patients with pH <5.5. Conclusion:The study of lithogenic factors with metabolic evaluation is interested in the changes that occur as the regions studied and according to other factors such as sex and urinary pH. Enviado: 14-02-2015 Revisado: 25-06-2015 Aceptado: 10-08-2015 Study of lithogenic factors in men and women with recurrent nephrolithiasis in the north area of Almeria Act...

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Section: Discussionunclassified

Study of lithogenic factors in men and women with recurrent nephrolithiasis in the north area of Almeria

Cano-García¹,

Roletto-Salmo²,

Hidalgo-Agulló³

2015

Actual. Med.

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“…Tefekli et al 35 referred to hypocitraturia as the most prevalent metabolic risk factor in children and adults with renal lithiasis (60.6%). Since the etiology of hypocitraturia is multifactorial and directly related to the consumption of animal protein, promoting acid overload, its incidence varies in the different studied regions 36 .…”

Section: Discussionmentioning

confidence: 99%

Investigação de nefrolitíase no Oeste do Paraná

Peres¹,

Almeida²,

Bolson³

et al. 2011

J. Bras. Nefrol.

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ResumoIntrodução: Nefrolitíase é comum e tem alta taxa de recorrência. Objetivos: Avaliar a prevalência das principais alterações metabólicas e anatômicas e a análise química do cálculo encontrado em pacientes com nefrolitíase na região Oeste do Paraná. Métodos: Foi realizado um estudo retrospectivo em 681 pacientes adultos com nefrolitíase. A investigação laboratorial incluiu pelo menos duas amostras de urina de 24 horas, com dosagens de cálcio, ácido úrico, citrato, oxalato, sódio e creatinina; cistinúria qualitativa, pH urinário após 12 horas de jejum e restrição hídrica, urocultura e análise química do cálculo, quando disponível. Técnicas de imagem renal incluíram pelo menos ultrassonografia e urografia excretora. Resultados: As alterações metabólicas mais frequentemente encontradas foram: hipercalciúria (51,8%), hiperuricosúria (27,6%) e hipocitratúria (23,5%). A análise química dos cálculos mostrou oxalato de cálcio em 85,7% dos casos. As alterações anatô-micas mais frequentes foram: cisto renal, duplicação pieloureteral e obstrução da junção pieloureteral. Conclusões: Este trabalho serviu de base para o conhecimento das características de pacientes com nefrolitíase na região Oeste do Paraná. Palavras-chave: nefrolitíase, hipercalciúria, oxalato de cálcio. AbstRActIntroduction: Nephrolithiasis is common and has a high rate of recurrence. Objectives: To assess the prevalence of the main metabolic and anatomical changes and the chemical analysis of stone found in patients with nephrolithiasis in the West region of Paraná. Methods: Retrospective study with 681 adult patients with nephrolithiasis. The laboratory investigation included at least two samples of 24-hour urine test with doses of calcium, uric acid, citrate, oxalate, sodium and creatinine; qualitative cystinuria, urinary pH following 12-hour fast and water restriction, urine culture and chemical analysis, when the stones were available. Renal imaging techniques included at least renal ultrasound and excretory urogram. Results: The metabolic changes most frequently found were: hypercalciuria (51.8%), hyperuricosuria (27.6%), and hypocitraturia (23.5%). Chemical analysis of stones showed calcium oxa late in 85.7% of the cases. The most frequently anatomical changes were renal cyst, duplicated ureter, and ureteropelvic junction obstruction. Conclusions: This paper served as a base for knowing the characteristics of patients with nephrolithiasis in the West area of Paraná.

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“…3,14 Çocuklarda taşların %70-80'i kalsiyum oksalat, %5-10'u ürik asit, %5-10'u strüvit (magnezyum amonyum fosfat), %1-5'i sistin taşlarıdır. [19][20][21][22][23][24] Nadiren ksantin ve 2,8-dihidroksiadenin taşları ile karşılaşılmaktadır.…”

Section: Patofi̇zyoloji̇unclassified

Urolithiasis in Childhood: Review

Zeybek¹,

Orman²

2017

Turkiye Klinikleri J Pediatr

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Metabolic Evaluation in Stone Disease Metabolic Differences Between the Pediatric and Adult Patients With Stone Disease

Cited by 38 publications

References 22 publications

Study of lithogenic factors in men and women with recurrent nephrolithiasis in the north area of Almeria

Study of lithogenic factors in men and women with recurrent nephrolithiasis in the north area of Almeria

Investigação de nefrolitíase no Oeste do Paraná

Urolithiasis in Childhood: Review

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