2023
DOI: 10.1101/2023.09.01.555371
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Metabolic evolution of pyranopterin-dependent biochemistry

Joshua E. Goldford,
Ranjani Murali,
Joan Selverstone Valentine
et al.

Abstract: Molybdenum (Mo)-dependent biochemistry is essential for many key metabolic pathways. However, theory and geological evidence suggests that its solubility during long intervals with low dioxygen would have limited its availability on early Earth. We developed models of metabolic evolution and found that reactions employing tungsten (W)-dependent biochemistry likely preceded Mo-dependent reactions, where Mo-usage increased dramatically after the production of dioxygen. Consistent with this finding, we analyzed g… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1
1

Relationship

1
1

Authors

Journals

citations
Cited by 2 publications
references
References 61 publications
(95 reference statements)
0
0
0
Order By: Relevance