Metabolic fate and pharmacokinetics of tissue residues of the anticoccidial drug robenidine in the rabbit. Incidence of coprophagy on its bioavailability

Durand, Elizabeth F.; Bories, Georges

doi:10.1021/jf00114a016

Cited by 5 publications

(1 citation statement)

References 7 publications

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“…By determining the content of drugs and their metabolites in different excretions, it is possible to verify the entry of drugs into the circulation and their main metabolic pathways. After exogenous drugs are administered through internal administration, part of them are absorbed into the body circulation through the small intestine and other parts of the body, while the others are excreted through the intestines along with feces [22,26]. The elimination of drugs entering circulation generally takes place in two ways: one is that they are directly excreted as the original drug without any metabolic transformation, and the other is that they are metabolized into other metabolites in the liver and other tissues by metabolic enzyme catalysis and then excreted through the bile or kidneys [25,27].…”

Section: Recovery Of Robh In Animalsmentioning

confidence: 99%

Mass Balance Studies of Robenidine Hydrochloride in the Body of Channel Catfish (Ictalurus punctatus)

Zhang,

Du,

et al. 2023

Animals

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This study aims to determine the mass balance of chlorpheniramine hydrochloride (ROBH) in the body of Channel catfish (Ictalurus punctatus). ROBH was administered orally at a dose of 20 mg/kg; following drug administration, the water samples were collected at predetermined time points (12, 24, 48, 72, 96, 120, 144, and 168 h), the experimental fish were executed after the water samples were obtained at 168 h, and the tissue samples were collected separately from the bones. The water and tissue samples were analyzed by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC–MS/MS) for concentrations of ROBH and its potential major metabolites, 4-chlorohippuric acid (PCHA) and 4-chlorobenzoic acid (PCBA). The tissue samples were prepared using a modified QuEChERS procedure; the water samples were prepared using a liquid–liquid extraction (LLE) procedure. The results show that the recovery rate of ROBH in fish is very low, less than 2% of the total amount of the drug, and the recovery in water can reach 80.7% of the total amount of the drug. The content of PCBA accounted for 42.4% of the total amount of the drug; the content of ROBH accounted for 38.3% of the total amount of the drug. The content of PCHA accounted for less than 1% of the total amount of the drug. The results show that, after a single administration, ROBH is rapidly metabolized in vivo and excreted in the form of ROBH as well as metabolite PCBA. ROBH and PCBA can be used as the main targets for the metabolism detection of ROBH in Channel catfish.

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Section: Recovery Of Robh In Animalsmentioning

confidence: 99%

Mass Balance Studies of Robenidine Hydrochloride in the Body of Channel Catfish (Ictalurus punctatus)

Zhang,

Du,

et al. 2023

Animals

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1989

Metabolic Maps of Pesticides

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Restraint collars. Part I: Elizabethan collars and other types of restraint collars

Brown¹

2006

Lab Anim

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Restraint collars can provide an investigator with a noninvasive means to prevent certain undesirable behaviors and provide a clinician with a nonpharmaceutical method to prevent an animal from inflicting self-injury; without proper use and monitoring, however, these collars can do more harm than good. This first part of our look at restraint collars introduces collar types and proper use. Next month's installment will review specific issues associated with the use of different types of collars for different species.

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Metabolic fate and pharmacokinetics of tissue residues of the anticoccidial drug robenidine in the rabbit. Incidence of coprophagy on its bioavailability

Cited by 5 publications

References 7 publications

Mass Balance Studies of Robenidine Hydrochloride in the Body of Channel Catfish (Ictalurus punctatus)

Mass Balance Studies of Robenidine Hydrochloride in the Body of Channel Catfish (Ictalurus punctatus)

References

Restraint collars. Part I: Elizabethan collars and other types of restraint collars

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