Metabolic Fate of Dopamine Prodrug TA-870. (4): Protein Binding of TA-870 in Humans, Rats and Dogs.

Abstract

The protein binding of TA-870 was investigated in human, dog and rat plas ma with centrifugal ultrafiltration method.The in vitro binding extent of TA-870 to dog and human plasma were 52-56 and 41%, respectively. The binding extent of TA-870 to human plasma was not influenced by other drugs. The binding of TA-870 to purified human albu min, al-acid glycoprotein and 7-globulin accounted for 56,47 and 5%, respec tively. The binding extent of radioactive substances to rat plasma, after oral administration of 3H-TA-870, were 26-55%.

An Orally Effective Peripheral Dopamine Prodrug: Docarpamine (TA‐870)

“…The extent of protein binding of docarpamine (0.5-50 pg/ml) was 40-56% in either human or dog plasma (2).…”