Metabolic Fate of Plasma Diamine Oxidase: Evidence of Isolated and Perfused Rat Liver Uptake

D’Agostino, Luciano; Ciacci, Carolina; Capuano, Gaetano; Daniele, Bruno; D’Argenio, Giuseppe; Barone, Maria Vittoria; Rodinò, Stefano; Budillon, G; Mazzacca, G

doi:10.1159/000199337

Cited by 23 publications

(8 citation statements)

References 10 publications

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“…This is the first systematic investigation demonstrating elevated concentrations of DAO in patients with liver disease. Of note, DAO is rapidly metabolized by rat liver 26 . Thus, the increased baseline concentration of DAO might be explained by a decreased clearance of DAO in patients with ESLD.…”

Section: Discussionmentioning

confidence: 96%

Regulation of histamine and diamine oxidase in patients undergoing orthotopic liver transplantation

Schiefer

Baron

Boehm

et al. 2020

Sci Rep

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increased concentrations of the vasodilator histamine have been observed in patients undergoing abdominal surgery. the role of histamine during orthotopic liver transplantation (oLt) has only been studied in animals. the aim of this study was to measure plasma concentrations of histamine and its degrading enzyme diamine oxidase (DAo) in patients undergoing orthotopic liver transplantation, and assess whether histamine or DAo correlate with intraoperative noradrenaline requirements. Histamine and DAO concentrations were measured in 22 adults undergoing liver transplantation and 22 healthy adults. Furthermore, norepinephrine requirements during liver transplantation were recorded. Baseline concentrations of histamine and DAo were greater in patients, who underwent liver transplantation, than in healthy individuals (Histamine: 6.4 nM, IQR[2.9-11.7] versus 4.3 nM, IQR[3.7-7.1], p = 0.029; DAO: 2.0 ng/mL, IQR[1.5-4.1] versus <0,5 ng/mL, IQR[<0.5-1.1], p < 0.001). During liver transplantation, histamine concentrations decreased to 1.8 nM, IQR[0.5-4.9] in the anhepatic phase (p < 0.0001 versus baseline), and to 1.5 nM, IQR[0.5-2.9] after reperfusion (p < 0.0001 versus baseline). In contrast, DAO concentrations increased to 35.5 ng/ml, IQR[20-50] in the anhepatic phase (p = 0.001 versus baseline) and to 39.5 ng/ml, IQR[23-64] after reperfusion (p = 0.001 versus baseline), correlating inversely with histamine. norepinephrine requirements during human liver transplantation correlated significantly with DAO concentrations in the anhepatic phase (r = 0.58, p = 0.011) and after reperfusion (r = 0.56; p = 0.022). In patients undergoing orthotopic liver transplantation, histamine concentrations decrease whereas DAo concentrations increase manifold. Diamine oxidase correlates with intraoperative norepinephrine requirements in patients undergoing oLt. Orthotopic liver transplantation (OLT) is the only curative procedure for end-stage liver disease (ESLD). Patients with ESLD usually present with a systemic hyperdynamic cardiovascular regulation, demonstrating an increased cardiac output, reduced systemic vascular resistance and impaired vascular responsiveness to stress. During OLT, patients are exposed to further major hemodynamic alterations primarily due to temporary caval clamping, blood loss and ischemia/reperfusion (I/R) injury. Temporary clamping of the inferior vena cava decreases cardiac output by approximately 50% due to a reduction in venous return to the heart 1,2 , while blood loss leads to hypovolemia. I/R injury, mainly characterized by oxidative damage and a severe inflammatory response, triggers the secretion of vasoactive mediators into the recipients' systemic circulation 3. Thus, OLT is frequently associated with hemodynamic instability of the recipient presenting clinically with hypotension, increased vasopressor support and cardiac arrhythmias.

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Section: Discussionmentioning

confidence: 96%

Regulation of histamine and diamine oxidase in patients undergoing orthotopic liver transplantation

Schiefer

Baron

Boehm

et al. 2020

Sci Rep

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“…Diamine oxidase (DAO) (D'Agostino et al, 1986;Biegański et al, 1983;Bragg et al, 1991;Bounous et al, 1984) plasma DAO activity is a candidate marker for ischemic small bowel injury particularly high concentration in the epithelial cells of the small intestine rapidly cleared by the liver Calprotectin (Costa et al, 2003) fecal concentration has been identified as a sensitive biomarker of intestinal inflammation highly sensitive non-invasive low specificity does not allow for discrimination of anatomical sites of intestinal injury Granulocyte marker protein (GMP) (Richter et al, 1997) pathophysiologically similar to calprotectin sensitive non-invasive biomarker of radiation induced injury…”

Section: Clinical Presentation Of Mucositismentioning

confidence: 99%

Plasma citrulline level as a biomarker for cancer therapy-induced small bowel mucosal damage.

et al. 2014

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Regimen-related mucosal toxicity is extremely common following cytotoxic chemotherapy and radiotherapy. Mucositis is as an important determinant of the inflammatory response and infectious complications in cancer treated patients. Most assessment scales for mucosal damage are focussed on oral mucositis, since it is easy to evaluate. Measuring gastrointestinal musocal damage objectively remains difficult because it cannot be seen directly or readily detected. One of potential non-invasive biomarkers of gastrointestinal mucosal damage is plasma citrulline level. Citrulline is an amino acid produced by small bowel enterocytes. Low concentration of free circulating citrulline signifies severe intestinal mucosal damage in humans with nonmalignant disorders, such as villous atrophy-associated diseases, short bowel syndrome, Crohn's disease, and is used in follow-up after small bowel transplantation. The plasma citrulline level is a reliable and objective biochemical marker of enterocyte mass and function in humans, and therefore can be used to monitor enterocyte toxicity resulting from chemotherapy and radiotherapy during anticancer therapy in patients with severely disturbed gut integrity.

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“…Following injury to intestinal epithelial cells DAO is released into the intestinal lumen and intercellular space where it is taken up by lymphatics and blood vessels [45] . Circulating DAO is rapidly cleared by the liver [47] . The plasma DAO activity has been suggested as a candidate marker for measuring ischemic small bowel injury [48][49][50] .…”

Section: Mucosal Transport and Barrier Functionmentioning

confidence: 99%

Biomarkers for radiation-induced small bowel epithelial damage: An emerging role for plasma Citrulline

Lutgens¹,

Lambin²

2007

WJG

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Reduction of cancer treatment-induced mucosal injury has been recognized as an important target for improving the therapeutic ratio as well as reducing the economic burden associated with these treatment related sequellae. Clinical studies addressing this issue are hampered by the fact that specific objective parameters, which enable monitoring of damage in routine clinical practice, are lacking. This review summarizes pros and cons of currently available endpoints for intestinal injury. The metabolic background and characteristics of plasma citrulline, a recently investigated biomarker specifically for small intestinal injury, are discussed in more detail.

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Metabolic Fate of Plasma Diamine Oxidase: Evidence of Isolated and Perfused Rat Liver Uptake

Cited by 23 publications

References 10 publications

Regulation of histamine and diamine oxidase in patients undergoing orthotopic liver transplantation

Regulation of histamine and diamine oxidase in patients undergoing orthotopic liver transplantation

Plasma citrulline level as a biomarker for cancer therapy-induced small bowel mucosal damage.

Biomarkers for radiation-induced small bowel epithelial damage: An emerging role for plasma Citrulline

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