Metabolic heat production and cold tolerance during cold stress of different intensity of adult and aged male C57BL/6J mice

Tatelman, Hal M.; Talan, Mark I.

doi:10.1016/0531-5565(93)90047-h

Cited by 6 publications

(3 citation statements)

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“…This observation that age did not impair a cold-induced increase in whole body energy expenditure may also explain why there was no clear age effect on EE under 12°C conditions when EE was normalized for BW, FFM, or ORGAN (Table 2). Studies in C57BL/6J mice have reported an age-related decline in cold-induced increase in heat production [14]–[16]. However, these studies involved restrained animals exposed to 6°C for a period 6 hours.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to measuring energy expenditure under typical ambient conditions (22°C), we also wished to determine the influence of Shc proteins on physiological response to an environmental condition (cold exposure) which stimulates energy expenditure. It has been documented that aging is associated with a diminished cold-induced increase in oxygen consumption and energy expenditure in mice [13]–[16], as well as humans [17]–[19]. In mice, these oxygen consumption/energy expenditure measurements are often completed in animals studied in environments very different from the home cage (i.e., lack of bedding, restraint) and exposed to temperatures ≤10°C [13]–[16].…”

Section: Introductionmentioning

confidence: 99%

“…It has been documented that aging is associated with a diminished cold-induced increase in oxygen consumption and energy expenditure in mice [13]–[16], as well as humans [17]–[19]. In mice, these oxygen consumption/energy expenditure measurements are often completed in animals studied in environments very different from the home cage (i.e., lack of bedding, restraint) and exposed to temperatures ≤10°C [13]–[16]. Relatively little is known about the influence of aging (and Shc proteins) on the acute stimulation of energy expenditure in response to moderate cold (12°C) exposure in animals housed in an environment similar to the home cage.The purpose of this study was to investigate the impact of aging and acute cold exposure on whole animal energy expenditure and substrate oxidation in ShcKO and WT mice.…”

Section: Introductionmentioning

confidence: 99%

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The Influence of Shc Proteins and Aging on Whole Body Energy Expenditure and Substrate Utilization in Mice

2012

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While it has been proposed that Shc family of adaptor proteins may influence aging by regulating insulin signaling and energy metabolism, the overall impact of Shc proteins on whole body energy metabolism has yet to be elucidated. Thus, the purpose of this study was to determine the influence of Shc proteins and aging on whole body energy metabolism in a mouse model under ambient conditions (22°C) and acute cold exposure (12°C for 24 hours). Using indirect respiration calorimetry, we investigated the impact of Shc proteins and aging on EE and substrate utilization (RQ) in p66 Shc−/− (ShcKO) and wild-type (WT) mice. Calorimetry measurements were completed in 3, 15, and 27 mo mice at 22°C and 12°C. At both temperatures and when analyzed across all age groups, ShcKO mice demonstrated lower 24 h total EE values than that of WT mice when EE data was expressed as either kJ per mouse, or adjusted by body weight or crude organ mass (ORGAN) (P≤0.01 for all). The ShcKO mice also had higher (P<0.05) fed state RQ values than WT animals at 22°C, consistent with an increase in glucose utilization. However, Shc proteins did not influence age-related changes in energy expenditure or RQ. Age had a significant impact on EE at 22°C, regardless of how EE data was expressed (P<0.05), demonstrating a pattern of increase in EE from age 3 to 15 mo, followed by a decrease in EE at 27 mo. These results indicate a decline in whole body EE with advanced age in mice, independent of changes in body weight (BW) or fat free mass (FFM). The results of this study indicate that both Shc proteins and aging should be considered as factors that influence energy expenditure in mice.

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Section: Discussionmentioning

confidence: 99%