Metabolic heat production during repeated testing at 24°C and 6°C in adult and aged male C57BL/6J mice: The effect of physical restraint before cold stress

Tatelman, Hal M.; Talan, Mark I.

doi:10.1016/0531-5565(90)90034-y

Cited by 11 publications

(1 citation statement)

References 34 publications

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“…The activation of BAT can be induced by exposure to cold temperatures. Earlier rodent studies have indicated that age significantly influences heat production capabilities in response to cold, with older mice exhibiting a reduced thermogenic effect ( Talan et al, 1985 ; Tatelman and Talan, 1990 ). Initially, researchers believed that BAT had limited thermogenic and metabolic functions in adult humans, due to the observation that BAT depots were more prevalent in infants ( Lean, 1989 ).…”

Section: Introductionmentioning

confidence: 99%

Assessment of cold exposure-induced metabolic changes in mice using untargeted metabolomics

Gong,

Zhao,

Chu

et al. 2023

Front. Mol. Biosci.

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Background: Cold exposure (CE) can effectively modulate adipose tissue metabolism and improve metabolic health. Although previous metabolomics studies have primarily focused on analyzing one or two samples from serum, brown adipose tissue (BAT), white adipose tissue (WAT), and liver samples, there is a significant lack of simultaneous analysis of multiple tissues regarding the metabolic changes induced by CE in mice. Therefore, our study aims to investigate the metabolic profiles of the major tissues involved.Methods: A total of 14 male C57BL/6J mice were randomly assigned to two groups: the control group (n = 7) and the CE group (n = 7). Metabolite determination was carried out using gas chromatography-mass spectrometry (GC-MS), and multivariate analysis was employed to identify metabolites exhibiting differential expression between the two groups.Results: In our study, we identified 32 discriminant metabolites in BAT, 17 in WAT, 21 in serum, 7 in the liver, 16 in the spleen, and 26 in the kidney, respectively. Among these metabolites, amino acids, fatty acids, and nucleotides emerged as the most significantly altered compounds. These metabolites were found to be associated with 12 differential metabolic pathways closely related to amino acids, fatty acids, and energy metabolism.Conclusion: Our study may provide valuable insights into the metabolic effects induced by CE, and they have the potential to inspire novel approaches for treating metabolic diseases.

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Section: Introductionmentioning

confidence: 99%