Metabolic, immunological and clinical characteristics in newly diagnosed Asian diabetes patients aged 12–40 years

Pan, Chang Yu; So, Wing‐Yee; Khalid, B. A. K.; Mohan, Viswanathan; Thai, A. C.; Zimmet, Paul; Cockram, Clive S.; Jørgensen, Lars N.; Yeo, Jing Ping

doi:10.1111/j.1464-5491.2004.01287.x

Cited by 26 publications

(33 citation statements)

References 34 publications

(43 reference statements)

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“…The evolving epidemic of obesity in youth as a result of global industrialization favoring energy conservation over energy expenditure is the main culprit for the increasingly younger age of diabetes development. Consistent with the role of insulin resistance in type 2 diabetes, development of cardiometabolic risk factors precedes the diagnosis of diabetes in a large proportion of patients (3,4).…”

mentioning

confidence: 89%

“…In susceptible ethnic groups including Asians, type 2 diabetes has emerged as the predominant form of dysglycemia in childhood and adolescence (2)(3)(4)(5). The evolving epidemic of obesity in youth as a result of global industrialization favoring energy conservation over energy expenditure is the main culprit for the increasingly younger age of diabetes development.…”

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confidence: 99%

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Prospective Study on the Incidences of Cardiovascular-Renal Complications in Chinese Patients With Young-Onset Type 1 and Type 2 Diabetes

et al. 2013

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OBJECTIVEWe examined metabolic profiles and cardiovascular-renal outcomes in a prospective cohort of Chinese patients with young-onset diabetes defined by diagnosis age ,40 years. Patients with type 1 diabetes and normal-weight (BMI ,23 kg/m 2 ) and overweight (BMI ‡23 kg/m 2 ) patients with type 2 diabetes were compared. RESEARCH DESIGN AND METHODSBetween 1995 and 2004, 2,323 patients (type 1 diabetes, n = 209; normal-weight type 2 diabetes, n = 636; and overweight type 2 diabetes, n = 1,478) underwent detailed clinical assessment. Incident cardiovascular disease (CVD) including coronary heart disease, stroke, and peripheral vascular disease were identified using hospital discharge diagnoses. End-stage renal disease (ESRD) was defined by glomerular filtration rate ,15 mL/min/1.73 m 2 or dialysis. RESULTSOverweight patients with type 2 diabetes had the worst metabolic profile and highest prevalence of microvascular complications. Over a median follow-up of 9.3 years, incidences of CVD were 0.6, 5.1, and 9.6 per 1,000 person-years in patients with type 1 diabetes, normal-weight patients with type 2 diabetes, and overweight patients with type 2 diabetes. A slide set summarizing this article is available online.

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confidence: 89%

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confidence: 99%

Prospective Study on the Incidences of Cardiovascular-Renal Complications in Chinese Patients With Young-Onset Type 1 and Type 2 Diabetes

et al. 2013

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“…But in the case of females more Malays (35%) compared to Chinese (14%) and Indians (15%), had high WHR indicating central obesity. 13 Ramachandran et al showed in his studies that more upper body adiposity measured as waist hip ratio found in south Indian population to be a greater risk factor for type 2 diabetes than general obesity. Indians with low BMI have WHR comparable to the Mexican Americans who are obese.…”

Section: Discussionmentioning

confidence: 97%

“…In the study by C Y Pan et al, 47% patients were found to be overweight (using the European classification of BMI >25 kg/ m 2 as overweight) However, recent research has shown that obesityrelated illness such as hypertension, diabetes and cardiovascular diseases tend to occur at lower BMI values in Asians and this has led to the suggested BMI > 23 kg/m 2 as being overweight 13 . Accordingly, (67%) of patients in this study were found to be overweight and 47% patients obese.…”

Section: Discussionmentioning

confidence: 99%

The Anthropometric and Biochemical Profile of Patients With Diabetes Mellitus in the Age Group of 12 - 35 Years

Suresh¹,

Kumar²,

K³

2014

jemds

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OBJECTIVES:Objective of this study was to look for different anthropometric measurements and laboratory abnormalities in diabetic patients whose age of onset is <35 years and >12 years getting treatment from Sri Manakula Vinayagar Medical College & Hospital. RESEARCH DESIGNS AND METHODS: A total of 130 patients who developed diabetes before the age of 35 were included in this descriptive study. The aim of the study was to look for different anthropometric measurements and derived estimates of body composition, in particular BMI, Waist-to-Height ratio, Waist-to-Hip ratio (WHR), and also to find out laboratory abnormalities like HbA1c, lipid abnormalities in diabetic patients whose age of onset <35 years and >12 Years getting treatment from our institution. RESULTS: Majority of them (78.4%) had BMI >23 and (92.7%) had central obesity. All female patients including type 1diabetes had high Waist Hip Ratio. Hypertension was present in (20.8%) patients (systolic BP >140 & diastolic > 90). Lipid abnormalities were found in more than half of the patients. Hypertriglyceridemia and Hypercholesterolemia were found more in type 2 diabetes patients. High LDL and low HDL were found in both type 1 and type 2 diabetes. Majority of the patients had poor glycemic control as indicated by high HbA1C. DKA was present in 9 patients; seven of these belonged to type 1 diabetes. CONCLUSION: Majority of patients had high BMI (>23). Among them majority of them had central obesity irrespective of the type of diabetes and also had poor glycemic control with high HbA1c. Lipid abnormalities were present in more than half of the patients with high numbers of Hypertriglyceridemia and Hypercholesterolemia in type 2 diabetes and high LDL and low HDL in both type 1 & 2 Diabetes.

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“…Malays (including Filipinos) have a higher risk for developing pediatric T2DM than other Asian groups [52]. Hypertension is a prevalent comorbidity or complication among Malay children with T2DM for which prevalence is similar to that in developed countries [53].…”

Section: Hypertensionmentioning

confidence: 99%

Pediatric type 2 diabetes mellitus complications: a systematic review of the literature

Jordan¹,

Jordan²

2012

J Diab Res Clin Met

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The incidence and prevalence of type 2 diabetes mellitus (T2DM) are increasing worldwide in the pediatric population. The increase has been attributed to obesity, lack of physical activity, improper diet, and family medical history. Type 2 diabetes mellitus has serious complications for children, including cardiovascular problems, dyslipidemia, hypertension, nonalcoholic fatty liver disease, pancreatic problems, pulmonary problems, and renal injury. Unfortunately, T2DM and its complications in the pediatric population remain largely understudied. As such, diabetes researchers, educators, and clinicians are forced to rely on information collected on adults with T2DM which may or may not be applicable to children with T2DM.

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Metabolic, immunological and clinical characteristics in newly diagnosed Asian diabetes patients aged 12–40 years

Cited by 26 publications

References 34 publications

Prospective Study on the Incidences of Cardiovascular-Renal Complications in Chinese Patients With Young-Onset Type 1 and Type 2 Diabetes

Prospective Study on the Incidences of Cardiovascular-Renal Complications in Chinese Patients With Young-Onset Type 1 and Type 2 Diabetes

The Anthropometric and Biochemical Profile of Patients With Diabetes Mellitus in the Age Group of 12 - 35 Years

Pediatric type 2 diabetes mellitus complications: a systematic review of the literature

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