Metabolic impact of saffron and crocin: an updated systematic and meta-analysis of randomised clinical trials

Efficacy and Safety of Curcumin Supplement on Improvement of Insulin Resistance in People with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…(5) The publication bias assessment was carried out in this study, and the publication bias of outcomes was excluded. In terms of improving metabolism, Roshanravan et al [ 37 ] found the protective effect of supplementing Crocus sativus L. on hyperlipidemia and hyperglycemia through systematic reviews and meta-analysis studies. Our research also found that curcumin has the same clinical effect in improving the metabolism of diabetes.…”

Effect of saffron supplementation on oxidative stress parameters: A systematic review and meta‐analysis of randomized placebo‐controlled trials

“…Saffron, also known as Crocus sativus, is a common Mediterranean spice plant. It is composed of four key ingredients, namely crocin, crocetin, picrocrocin, and safranal (Roshanravan et al, 2020).…”

“…It is composed of four key ingredients, namely crocin, crocetin, picrocrocin, and safranal (Roshanravan et al., 2020 ). Previous meta‐analyses have illustrated the beneficial effects of saffron on select blood pressure, glycemic, lipid, metabolic, and anthropometric indices (Asbaghi et al., 2019 ; Giannoulaki et al., 2020 ; Pourmasoumi et al., 2019 ; Rahmani et al., 2019 ; Roshanravan et al., 2020 ). A key property of saffron is its antioxidant capacity (Boskabady & Farkhondeh, 2016 ; Mashmoul et al., 2013 ).…”

Six Common Herbs with Distinctive Bioactive, Antioxidant Components. A Review of Their Separation Techniques

“…Apart from the value of stigmas as spice, they appear to be a significant source of bioactive components against a broad range of pathological conditions and disorders as presented in numerous reports. In recent papers it has been evidenced that crocins can modulate the serum lipid profile in patients with metabolic disorders [ 188 ], prevent cancer, and present antitumor activities, according to experiments with cultured human malignant cell lines and animal models [ 189 ]. Kazemi et al [ 190 ] have demonstrated that treatment of patients, with mild to moderate obsessive-compulsive disorder, with saffron crocin is equally effective to fluoxetine, while saffron intake has been associated with improvements in sleep quality in adults with self-reported sleep complaints [ 191 ].…”