Metabolic impact of the VDR rs1544410 in diabetic retinopathy

Assis, Caroline Severo de; Diniz, Tainá Gomes; Alcântara, João Otávio Scarano; Brito, Vanessa Polyana Alves de Sousa; Nascimento, Rayner Anderson Ferreira do; Nunes, Mayara Karla dos Santos; Silva, Alexandre; Evangelista, Isabella; Viturino, Marina Gonçalves Monteiro; Lima, Rafaela Lira Formiga Cavalcanti de; Persuhn, Darlene Camati

doi:10.1371/journal.pone.0263346

Cited by 5 publications

(3 citation statements)

References 55 publications

(79 reference statements)

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“…We found in the studied population that the polymorphisms rs1544410 ( Bsm I) and rs2228570 ( Fok I) were associated with the severe form of the disease and increased the rate of SOM occurrence. Other diseases, such as rheumatoid arthritis, COVID‐19, diabetic complications, multiple sclerosis and systemic lupus erythematosus, among others, have already been related to polymorphisms in the VDR gene (Apaydin et al 2022; Assis et al, 2022; Zhang, Lu, et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…systemic lupus erythematosus, among others, have already been related to polymorphisms in the VDR gene(Apaydin et al 2022;Assis et al, 2022;Zhang, Lu, et al, 2020).The human VDR gene is located on chromosome 12q12-q14 and comprises 11 exons and 11 introns. Polymorphisms named BsmI, FokI and TaqI are related to the enzyme that recognises the restriction site TA B L E 3 Genotypic and allelic frequencies, Hardy-Weinberg equilibrium of polymorphisms in VDR gene in oncopaediatric patients with or without oral mucositis (n = 102) Abbreviations: n, absolute frequency; %, percentage frequency; −, missing value; HWE, Hardy-Weinberg Equilibrium.…”

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confidence: 99%

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Polymorphism but not methylation status in the vitamin D receptor gene contributes to oral mucositis in children

et al. 2022

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ObjectiveTo investigate the relationship between the polymorphisms rs1544410 (BsmI), rs2228570 (FokI) and rs731236 (TaqI) and DNA methylation status in the VDR gene (vitamin D receptor) with oral mucositis (OM) in oncopaediatric patients treated with methotrexate (MTX®).MethodsThe population comprised healthy patients with haematological malignancies aged between 5 and 19 years. An evaluation of oral conditions was performed using the Oral Assessment Guide. Demographic, clinical, biochemical and haematological data were obtained from medical records. Genomic DNA from oral mucosal cells was used for the analysis of polymorphisms (n = 102) (PCR‐restriction fragment length polymorphism) and DNA methylation (n = 81) (methylation‐specific PCR).ResultsMales predominated (57.8%), and the mean age was 10.3 years (±4.7). OM affected 84.3% of patients, of which 53.1% developed severe oral mucositis (SOM). Patients with OM had lower platelet and leukocyte counts (p < 0.05). The G allele of rs1544410 (p = 0.040) and the CT genotype of rs2228570 polymorphisms were associated with SOM (p = 0.038). A partially methylated status in the VDR promoter was found in all patients.ConclusionOM is associated with lower leukocyte and platelet counts. SOM is associated with the rs1544410 and rs2228570 polymorphisms. The methylation status of the VDR is not associated with inflammation or exposure to MTX®.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Polymorphism but not methylation status in the vitamin D receptor gene contributes to oral mucositis in children

et al. 2022

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“…Chronic hyperglycemia and problems of the metabolism of carbohydrates, fats, and proteins as a result of defects in insulin *Corresponding Author: Muntaha A. Arif montaha.abdulmajeed1109f@comed.uobaghdad.edu .iq secretion, insulin action, or both are characteristics of diabetes mellitus (DM), one of the chronic metabolic disorders that is marked by hyperglycemia (2)(3). The danger of T2DM is significantly reduced by vitamin D, a benefit that is probably mediated by the vitamin's effects on beta cell activity, insulin sensitivity, and inflammation throughout the body (4)(5)(6). Its development appears to be influenced by a number of variables, including genetic, dietary, environmental, and lifestyle factors.…”

Section: Introductionmentioning

confidence: 99%

Study some biochemical parameters in patients with Coronary artery disease with and without Type 2 diabetes

A. Arif,

K. Rasheed,

A. Ismaeel

2024

J Fac Med Baghdad

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Background: Impaired lipid metabolism are well recognized factors for Coronary artery disease (CAD) which is the major reason of mortality and morbidity all over world. The incident of CAD with type 2 diabetes mellitus (T2DM) is growing. Aim: The current study aimed to study some biochemical variables (vitamin D3, lipid profile, Insulin, FBG and HbA1C) in patients with diabetes and coronary heart disease and compare them with healthy people. Subjects and Methods: The study was conducted in human beings (apparently healthy and patients). It is statistically considered as [case- control study], the voluntaries were divided as following: 40 apparently healthy persons (40 male) were recruited through advertisement among laboratories and hospital staff in the three medical centers previously mentioned and from friends in Baghdad. 40 voluntaries patients with T2DM were taken, of them (40 male) were recruited from the specialized center for endocrinology and diabetes. 55 voluntaries patients who had CAD (55 male), 55 patients who have had T2DM with CAD (55 male). Results: the results evaluating the BMI of participant revealed that 16.3% had normal BMI, 55.8% were overweight and 27.9% were obese. 65.3% had vitamin D. insufficiency and 16.8% had vitamin D deficiency. The glycemic control evaluation shows that 37.4% had good glycemic control and 16.8% had poor control and 45.8% had excellent control. All participant had insulin resistance in which 31.6% had early resistance. Otherwise, a statistical significant difference in mean level of BMI, vitamin D, insulin level, HOMA-IR, FBS and HbA1c between the 4 groups. For lipid profile, Control group participant had significant lower total cholesterol level in compare to the other groups. Control group participant had significant lower TG level in compare to the other groups. Control group participant had significant higher HDL in compare in CAD group and CAD with DM group. Control group participant had significant lower LDL in compare in CAD group and CAD with DM group. Conclusions: Based on the results of the current study, it was found that there is a strong association between low vitamin D and cardiovascular disease, and it was also found that insulin resistance, which mainly causes type 2 diabetes, has increased health problems in CAD patients. On the other hand, the current study demonstrated that high levels of LDL and cholesterol were closely associated with events and increased risk of CAD.

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Delving the vitamin D receptor variation and expression profiles in the context of type 2 diabetes among families

Parveen,

Batool,

Wajid

et al. 2024

Mol Biol Rep

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Metabolic impact of the VDR rs1544410 in diabetic retinopathy

Cited by 5 publications

References 55 publications

Polymorphism but not methylation status in the vitamin D receptor gene contributes to oral mucositis in children

Polymorphism but not methylation status in the vitamin D receptor gene contributes to oral mucositis in children

Study some biochemical parameters in patients with Coronary artery disease with and without Type 2 diabetes

Delving the vitamin D receptor variation and expression profiles in the context of type 2 diabetes among families

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