Metabolic improvement of morbid obese patients following Roux-en-Y gastric bypass surgery: A prospective study in Mashhad, Iran

Fallahi-shahabad, Sahar; Mazidi, Mohsen; Tavasoli, Alireza; Rezaie, Peyman; Rohani, Fatemeh; Habibzadeh, Simin-Dokht; Darchini-Maragheh, Emadodin; Sefidi, Z S Sang; Safarian, Mohammad; Mobarhan, Majid Ghayour; Rajabi, Mohammad Taghi; Norouzy, Abdolreza; Parizadeh, Seyed Mohammad Reza; Akhlaghi, Saeed; Tavalaie, Shima; Firouzi, Fatemeh; Nematy, Mohsen

doi:10.1007/s12664-016-0661-0

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…In addition, significant post-operative improvement of gluco-metabolic profiles was observed during follow-up in our study. Improvement of HbA 1C without medications has been reported in other studies[1,21,28]. …”

Section: Discussionsupporting

confidence: 70%

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Effect of bariatric surgery on adiposity and metabolic profiles: A prospective cohort study in Middle-Eastern patients

Mazidi

Rezaie

Jangjoo

et al. 2017

WJD

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AIMTo investigate changes in adiposity and cardio-metabolic risk profile following Roux-en-Y gastric bypass in patients of Middle Eastern ethnicity with severe obesity.METHODSThis prospective cohort study involved 92 patients who met the indications of bariatric surgery. Post-procedure markers of obesity and cardiometabolic profile were monitored regularly for a year.RESULTSMean body mass index decreased by 29.5% from 41.9 to 29.5 kg/m2 between baseline and 12-mo follow-up, while mean fat mass decreased by 45.9% from 64.2 kg to 34.7 kg. An improvement was also observed in the gluco-metabolic profile with both fasting glucose and HbA1c substantially decreasing (P < 0.001).CONCLUSIONThe present study shows the short to medium term (1 year) health benefits of bariatric surgery for patients of Middle Eastern ethnicity.

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Section: Discussionsupporting

confidence: 70%

“…Obesity and related complications pose increasing health challenges worldwide[1]. Obesity is associated with the development of various comorbidities including type 2 diabetes mellitus, hypertension, and dyslipidemia, which are well-documented risk factors for cardiovascular disease (CVD), as well as musculoskeletal disorders[2-5].…”

Section: Introductionmentioning

confidence: 99%

Effect of bariatric surgery on adiposity and metabolic profiles: A prospective cohort study in Middle-Eastern patients

Mazidi

Rezaie

Jangjoo

et al. 2017

WJD

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Mechanisms of Action of Surgical Interventions on Weight-Related Diseases: the Potential Role of Bile Acids

et al. 2017

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Surgical interventions for weight-related diseases (SWRD) may have substantial and sustainable effect on weight reduction, also leading to a higher remission rate of type 2 diabetes (T2D) mellitus than any other medical treatment or lifestyle intervention. The resolution of T2D after Roux-en-Y gastric bypass (RYGB) typically occurs too quickly to be accounted for by weight loss alone, suggesting that these operations have a direct impact on glucose homeostasis. The mechanisms underlying these beneficial effects however remain unclear. Recent research suggests that changes in the concentrations of plasma bile acids might contribute to these metabolic changes after surgery. In this review, we aimed to outline the potential role of bile acids in SWRD. We systematically reviewed MEDLINE, SCOPUS, and Web of Science for articles reporting the effect of SWRD on outcomes published between 1969 and 2016. We found that changes in circulating bile acids after surgery may play a major role through activation of the farnesoid X receptor A (FXRA), the fibroblast growth factor 19 (FGF19), and the G protein-coupled bile acid receptor (TGR5). Bile acid concentration increased significantly after RYGB. Some studies suggest that a transitory decrease occurs at 1 week post-surgery, followed by a gradual increase. Most studies have shown the increase to be proportionate by all bile acid subtypes. Bile acids can regulate glucose metabolism through the expression of TGR5 receptor in L cells, resulting in a release of glucagon-like peptide 1 (GLP-1). It may also induce the synthesis and secretion of FGF19 in ileal cells, thereby improving insulin sensitivity and regulating glucose metabolism. All the present SWRD are involved with changes in food stimulation to the stomach. This implies that discovering and developing the antagonists to TGR5 and FXRA may effectively control metabolic syndrome and the elucidation of the mechanisms underlying the physiological effects related to weight loss and T2D remission after surgery may help to identify new drug targets.

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Lipid Profile and the Frequency of Dyslipidemia in Iranian Adolescents with Severe Obesity, Who Were Candidates for Bariatric Surgery

Soheilipour,

Geram

2024

OBES SURG

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Metabolic improvement of morbid obese patients following Roux-en-Y gastric bypass surgery: A prospective study in Mashhad, Iran

Abstract: It appears reasonable that multidisciplinary treatment including surgical alternatives should be concerned for all morbidly obese patients, considering high rate of failure of conservative medical therapy in this setting.

Cited by 6 publications

References 45 publications

Effect of bariatric surgery on adiposity and metabolic profiles: A prospective cohort study in Middle-Eastern patients

Effect of bariatric surgery on adiposity and metabolic profiles: A prospective cohort study in Middle-Eastern patients

Mechanisms of Action of Surgical Interventions on Weight-Related Diseases: the Potential Role of Bile Acids

Lipid Profile and the Frequency of Dyslipidemia in Iranian Adolescents with Severe Obesity, Who Were Candidates for Bariatric Surgery

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